ID   CC124_PONAB             Reviewed;         223 AA.
AC   Q5R8X8;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=Coiled-coil domain-containing protein 124;
GN   Name=CCDC124;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Required for proper progression of late cytokinetic stages.
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with RASGEF1B. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250}. Midbody {ECO:0000250}.
CC       Note=Colocalizes with gamma-tubulin at interphase, prophase, metaphase,
CC       and anaphase. Relocates from centrosome to midbody at telophase (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CCDC124 family. {ECO:0000305}.
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DR   EMBL; CR859620; CAH91782.1; -; mRNA.
DR   AlphaFoldDB; Q5R8X8; -.
DR   SMR; Q5R8X8; -.
DR   STRING; 9601.ENSPPYP00000024289; -.
DR   eggNOG; KOG3223; Eukaryota.
DR   InParanoid; Q5R8X8; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0030496; C:midbody; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   InterPro; IPR010422; Ccdc124/Oxs1.
DR   PANTHER; PTHR21680; PTHR21680; 1.
DR   Pfam; PF06244; Ccdc124; 1.
PE   2: Evidence at transcript level;
KW   Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW   Phosphoprotein; Reference proteome.
FT   CHAIN           1..223
FT                   /note="Coiled-coil domain-containing protein 124"
FT                   /id="PRO_0000263737"
FT   REGION          1..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          204..223
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          44..82
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        14..84
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        99..126
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         141
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96CT7"
FT   MOD_RES         194
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q96CT7"
SQ   SEQUENCE   223 AA;  25816 MW;  A8BD7D12701B976B CRC64;
     MPKKFQGENT KSAAARARRA EAKAAADAKK QKEPEDAYWK DDDKHVMRKE QRKEEKEKRR
     LDQLERKKET QRLLEEEDSK LKGGKAPRVA TSSKVTRAQI EDTLRRDHQL REAPDTAEKA
     KSHLEVPLEE NVNRRVLEEG SVEARTIEDA IAVLSVAEEA ADRHPERRQR AAFTAFEEAQ
     LPRLKQENPN MRLSQLKQLL KKEWLRSPDN PMNQRAVPFN APK