Z585B_HUMAN
ID Z585B_HUMAN Reviewed; 769 AA.
AC Q52M93; Q8IZD3; Q96JW6;
DT 25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Zinc finger protein 585B;
DE AltName: Full=zinc finger protein 41-like protein;
GN Name=ZNF585B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RA Guo J.H., Yu L.;
RL Submitted (SEP-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 296-769.
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB55400.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AY147015; AAN61169.1; -; mRNA.
DR EMBL; BC093625; AAH93625.1; -; mRNA.
DR EMBL; AK027834; BAB55400.1; ALT_INIT; mRNA.
DR CCDS; CCDS12500.1; -.
DR RefSeq; NP_689492.3; NM_152279.3.
DR AlphaFoldDB; Q52M93; -.
DR SMR; Q52M93; -.
DR BioGRID; 124927; 7.
DR IntAct; Q52M93; 5.
DR MINT; Q52M93; -.
DR STRING; 9606.ENSP00000433773; -.
DR iPTMnet; Q52M93; -.
DR PhosphoSitePlus; Q52M93; -.
DR BioMuta; ZNF585B; -.
DR DMDM; 74762154; -.
DR jPOST; Q52M93; -.
DR MassIVE; Q52M93; -.
DR MaxQB; Q52M93; -.
DR PaxDb; Q52M93; -.
DR PeptideAtlas; Q52M93; -.
DR PRIDE; Q52M93; -.
DR Antibodypedia; 48049; 55 antibodies from 16 providers.
DR DNASU; 92285; -.
DR Ensembl; ENST00000532828.7; ENSP00000433773.1; ENSG00000245680.11.
DR GeneID; 92285; -.
DR KEGG; hsa:92285; -.
DR MANE-Select; ENST00000532828.7; ENSP00000433773.1; NM_152279.4; NP_689492.3.
DR UCSC; uc002ofq.3; human.
DR CTD; 92285; -.
DR DisGeNET; 92285; -.
DR GeneCards; ZNF585B; -.
DR HGNC; HGNC:30948; ZNF585B.
DR HPA; ENSG00000245680; Low tissue specificity.
DR neXtProt; NX_Q52M93; -.
DR OpenTargets; ENSG00000245680; -.
DR PharmGKB; PA134925877; -.
DR VEuPathDB; HostDB:ENSG00000245680; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161781; -.
DR InParanoid; Q52M93; -.
DR OMA; VHMRVKP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q52M93; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; Q52M93; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q52M93; -.
DR BioGRID-ORCS; 92285; 13 hits in 1052 CRISPR screens.
DR GenomeRNAi; 92285; -.
DR Pharos; Q52M93; Tdark.
DR PRO; PR:Q52M93; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q52M93; protein.
DR Bgee; ENSG00000245680; Expressed in secondary oocyte and 139 other tissues.
DR ExpressionAtlas; Q52M93; baseline and differential.
DR Genevisible; Q52M93; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 19.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 21.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 21.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 23.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..769
FT /note="Zinc finger protein 585B"
FT /id="PRO_0000047679"
FT DOMAIN 27..97
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 158..180
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 186..208
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 214..236
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 438..460
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 466..488
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 494..516
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 522..544
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 550..572
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 578..600
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 606..628
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 634..656
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 662..684
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 690..712
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 718..740
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 746..768
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..24
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..16
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 467
FT /note="V -> I (in dbSNP:rs1657509)"
FT /id="VAR_059923"
FT CONFLICT 186
FT /note="Y -> P (in Ref. 1; AAN61169)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 769 AA; 88066 MW; EA70D74DE81536FF CRC64;
MPASWTSPQK SSALAPEDHG SSYEGSVSFR DVAIDFSREE WRHLDLSQRN LYRDVMLETY
SHLLSVGYQV PKPEVVMLEQ GKEPWALQGE RPRHSCPGEK LWDHNQHRKI IGYKPASSQD
QKIYSGEKSY ECAEFGKSFT WKSQFKVHLK VPTGEKLYVC IECGRAFVQK PEFITHQKTH
MREKPYKCNE CGKSFFQVSS LFRHHRIHTG EKLYECSECG KGFPYNSDLS IHEKIHTGER
HHECTDCGKA FTQKSTLKIH QKIHTGERSY ICIECGQAFI QKTQLIAHRR IHSGEKPYEC
NNCGKSFISK SQLQVHQRVH TRVKPYICTE YGKVFSNNSN LITHEKIQSR EKSSICTECG
KAFTYRSELI IHQRIHTGEK PYECSDCGRA FTQKSALTVH QRIHTGEKSY ICMKCGLAFI
RKAHLITHQI IHTGEKPYKC GHCGKLFTSK SQLHVHKRIH TGEKPYVCNK CGKAFTNRSN
LITHQKTHTG EKSYICSKCG KAFTQRSDLI THQRIHTGEK PYECNTCGKA FTQKSNLNIH
QKIHTGERQY ECHECGKAFN QKSILIVHQK IHTGEKPYVC TECGRAFIRK SNFITHQRIH
TGEKPYECSD CGKSFTSKSQ LLVHQPVHTG EKPYVCAECG KAFSGRSNLS KHQKTHTGEK
PYICSECGKT FRQKSELITH HRIHTGEKPY ECSDCGKSFT KKSQLQVHQR IHTGEKPYVC
AECGKAFSNR SNLNKHQTTH TGDKPYKCGI CGKGFVQKSV FSVHQSSHA
