Z587B_HUMAN
ID Z587B_HUMAN Reviewed; 402 AA.
AC E7ETH6; B4DR41;
DT 21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT 08-MAR-2011, sequence version 1.
DT 03-AUG-2022, entry version 82.
DE RecName: Full=Zinc finger protein 587B;
GN Name=ZNF587B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-366, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25218447; DOI=10.1038/nsmb.2890;
RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA Vertegaal A.C.;
RT "Uncovering global SUMOylation signaling networks in a site-specific
RT manner.";
RL Nat. Struct. Mol. Biol. 21:927-936(2014).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK299091; BAG61153.1; -; mRNA.
DR EMBL; AC010522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS56109.1; -.
DR RefSeq; NP_001191747.1; NM_001204818.1.
DR AlphaFoldDB; E7ETH6; -.
DR SMR; E7ETH6; -.
DR BioGRID; 945166; 6.
DR IntAct; E7ETH6; 1.
DR STRING; 9606.ENSP00000392410; -.
DR iPTMnet; E7ETH6; -.
DR PhosphoSitePlus; E7ETH6; -.
DR BioMuta; ZNF587B; -.
DR EPD; E7ETH6; -.
DR MassIVE; E7ETH6; -.
DR MaxQB; E7ETH6; -.
DR PaxDb; E7ETH6; -.
DR PeptideAtlas; E7ETH6; -.
DR PRIDE; E7ETH6; -.
DR ProteomicsDB; 18207; -.
DR DNASU; 100293516; -.
DR Ensembl; ENST00000442832.8; ENSP00000392410.2; ENSG00000269343.9.
DR GeneID; 100293516; -.
DR KEGG; hsa:100293516; -.
DR UCSC; uc021vcp.2; human.
DR CTD; 100293516; -.
DR DisGeNET; 100293516; -.
DR GeneCards; ZNF587B; -.
DR HGNC; HGNC:37142; ZNF587B.
DR HPA; ENSG00000269343; Low tissue specificity.
DR neXtProt; NX_E7ETH6; -.
DR OpenTargets; ENSG00000269343; -.
DR VEuPathDB; HostDB:ENSG00000269343; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164660; -.
DR InParanoid; E7ETH6; -.
DR OrthoDB; 1600969at2759; -.
DR PathwayCommons; E7ETH6; -.
DR BioGRID-ORCS; 100293516; 9 hits in 1071 CRISPR screens.
DR ChiTaRS; ZNF587B; human.
DR GenomeRNAi; 100293516; -.
DR Pharos; E7ETH6; Tdark.
DR PRO; PR:E7ETH6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; E7ETH6; protein.
DR Bgee; ENSG00000269343; Expressed in secondary oocyte and 184 other tissues.
DR ExpressionAtlas; E7ETH6; baseline and differential.
DR Genevisible; E7ETH6; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 1: Evidence at protein level;
KW Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..402
FT /note="Zinc finger protein 587B"
FT /id="PRO_0000416243"
FT DOMAIN 15..91
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 92..114
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 120..142
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..383
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 177
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9H707"
FT CROSSLNK 200
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9H707"
FT CROSSLNK 253
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:Q9H707"
FT CROSSLNK 366
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25218447"
FT CONFLICT 83
FT /note="V -> M (in Ref. 1; BAG61153)"
FT /evidence="ECO:0000305"
FT CONFLICT 390
FT /note="K -> G (in Ref. 1; BAG61153)"
FT /evidence="ECO:0000305"
FT CONFLICT 396
FT /note="I -> M (in Ref. 1; BAG61153)"
FT /evidence="ECO:0000305"
FT CONFLICT 398
FT /note="K -> R (in Ref. 1; BAG61153)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 402 AA; 45541 MW; 57CEA54233B91BAF CRC64;
MAVVATLRLS AQGTVTFEDV AVKFTQEEWN LLSEAQRCLY RDVTLENLAL MSSLGCWCGV
EDEAAPSKQS IYIQRETQVR TPVTGVSPKK AHPCEMCGPI LGDILHVADH QGTHHKQKLH
RCEAWGNKLY DSGNFHQHQN EHIGEKPYRG SVEEALFVKR CKLHVSGESS VFSESGKDFL
PRSGLLQQEA SHTGEKSNSK TECVSPFQCG GAHYSHGDSM KHFSTKHILS QHQRLLPREE
CYVCCECGKS FSKYVSFSNH QRVHSGKRPY ECGECEKSFS QKSSLIQHQQ FHTGGKPYGC
EECGKYFSLE GYLRRHQKVH AGKGPYECGE CGKSFSSNVN LKSHQRIHTG ERPYKCGECE
KSFSRKPSLS YHQRFGRPRW VDHKDRKEFK TSLGNIVKSC LF