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Z587B_HUMAN
ID   Z587B_HUMAN             Reviewed;         402 AA.
AC   E7ETH6; B4DR41;
DT   21-MAR-2012, integrated into UniProtKB/Swiss-Prot.
DT   08-MAR-2011, sequence version 1.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Zinc finger protein 587B;
GN   Name=ZNF587B;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Teratocarcinoma;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-366, AND IDENTIFICATION BY MASS
RP   SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=25218447; DOI=10.1038/nsmb.2890;
RA   Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA   Vertegaal A.C.;
RT   "Uncovering global SUMOylation signaling networks in a site-specific
RT   manner.";
RL   Nat. Struct. Mol. Biol. 21:927-936(2014).
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AK299091; BAG61153.1; -; mRNA.
DR   EMBL; AC010522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS56109.1; -.
DR   RefSeq; NP_001191747.1; NM_001204818.1.
DR   AlphaFoldDB; E7ETH6; -.
DR   SMR; E7ETH6; -.
DR   BioGRID; 945166; 6.
DR   IntAct; E7ETH6; 1.
DR   STRING; 9606.ENSP00000392410; -.
DR   iPTMnet; E7ETH6; -.
DR   PhosphoSitePlus; E7ETH6; -.
DR   BioMuta; ZNF587B; -.
DR   EPD; E7ETH6; -.
DR   MassIVE; E7ETH6; -.
DR   MaxQB; E7ETH6; -.
DR   PaxDb; E7ETH6; -.
DR   PeptideAtlas; E7ETH6; -.
DR   PRIDE; E7ETH6; -.
DR   ProteomicsDB; 18207; -.
DR   DNASU; 100293516; -.
DR   Ensembl; ENST00000442832.8; ENSP00000392410.2; ENSG00000269343.9.
DR   GeneID; 100293516; -.
DR   KEGG; hsa:100293516; -.
DR   UCSC; uc021vcp.2; human.
DR   CTD; 100293516; -.
DR   DisGeNET; 100293516; -.
DR   GeneCards; ZNF587B; -.
DR   HGNC; HGNC:37142; ZNF587B.
DR   HPA; ENSG00000269343; Low tissue specificity.
DR   neXtProt; NX_E7ETH6; -.
DR   OpenTargets; ENSG00000269343; -.
DR   VEuPathDB; HostDB:ENSG00000269343; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000164660; -.
DR   InParanoid; E7ETH6; -.
DR   OrthoDB; 1600969at2759; -.
DR   PathwayCommons; E7ETH6; -.
DR   BioGRID-ORCS; 100293516; 9 hits in 1071 CRISPR screens.
DR   ChiTaRS; ZNF587B; human.
DR   GenomeRNAi; 100293516; -.
DR   Pharos; E7ETH6; Tdark.
DR   PRO; PR:E7ETH6; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; E7ETH6; protein.
DR   Bgee; ENSG00000269343; Expressed in secondary oocyte and 184 other tissues.
DR   ExpressionAtlas; E7ETH6; baseline and differential.
DR   Genevisible; E7ETH6; HS.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 5.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 6.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 4.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 5.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE   1: Evidence at protein level;
KW   Isopeptide bond; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Ubl conjugation; Zinc; Zinc-finger.
FT   CHAIN           1..402
FT                   /note="Zinc finger protein 587B"
FT                   /id="PRO_0000416243"
FT   DOMAIN          15..91
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         92..114
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         120..142
FT                   /note="C2H2-type 2; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         242..264
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         270..292
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         298..320
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         326..348
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         354..383
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   CROSSLNK        177
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H707"
FT   CROSSLNK        200
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H707"
FT   CROSSLNK        253
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H707"
FT   CROSSLNK        366
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0007744|PubMed:25218447"
FT   CONFLICT        83
FT                   /note="V -> M (in Ref. 1; BAG61153)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        390
FT                   /note="K -> G (in Ref. 1; BAG61153)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        396
FT                   /note="I -> M (in Ref. 1; BAG61153)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        398
FT                   /note="K -> R (in Ref. 1; BAG61153)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   402 AA;  45541 MW;  57CEA54233B91BAF CRC64;
     MAVVATLRLS AQGTVTFEDV AVKFTQEEWN LLSEAQRCLY RDVTLENLAL MSSLGCWCGV
     EDEAAPSKQS IYIQRETQVR TPVTGVSPKK AHPCEMCGPI LGDILHVADH QGTHHKQKLH
     RCEAWGNKLY DSGNFHQHQN EHIGEKPYRG SVEEALFVKR CKLHVSGESS VFSESGKDFL
     PRSGLLQQEA SHTGEKSNSK TECVSPFQCG GAHYSHGDSM KHFSTKHILS QHQRLLPREE
     CYVCCECGKS FSKYVSFSNH QRVHSGKRPY ECGECEKSFS QKSSLIQHQQ FHTGGKPYGC
     EECGKYFSLE GYLRRHQKVH AGKGPYECGE CGKSFSSNVN LKSHQRIHTG ERPYKCGECE
     KSFSRKPSLS YHQRFGRPRW VDHKDRKEFK TSLGNIVKSC LF
 
 
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