Z687A_DANRE
ID Z687A_DANRE Reviewed; 1246 AA.
AC A0A0R4IYX6;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 1.
DT 03-AUG-2022, entry version 34.
DE RecName: Full=Zinc finger protein 687a;
GN Name=znf687a;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=26849110; DOI=10.1016/j.ajhg.2015.12.016;
RA Divisato G., Formicola D., Esposito T., Merlotti D., Pazzaglia L.,
RA Del Fattore A., Siris E., Orcel P., Brown J.P., Nuti R., Strazzullo P.,
RA Benassi M.S., Cancela M.L., Michou L., Rendina D., Gennari L.,
RA Gianfrancesco F.;
RT "ZNF687 mutations in severe paget disease of bone associated with giant
RT cell tumor.";
RL Am. J. Hum. Genet. 98:275-286(2016).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N1G0}.
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in kidney,
CC spleen and ovary. {ECO:0000269|PubMed:26849110}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed in the initial stages of
CC development (4-cell up to 1k-2k cell stages). Expression slightly
CC increases again between 24 hours and 5 dpf and after 20 dpf. Up-
CC regulated during regeneration of the caudal fin after amputation.
CC {ECO:0000269|PubMed:26849110}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; FP929011; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_001922058.2; XM_001922023.6.
DR AlphaFoldDB; A0A0R4IYX6; -.
DR STRING; 7955.ENSDARP00000103862; -.
DR PaxDb; A0A0R4IYX6; -.
DR Ensembl; ENSDART00000167919; ENSDARP00000141063; ENSDARG00000102774.
DR Ensembl; ENSDART00000170604; ENSDARP00000133103; ENSDARG00000102774.
DR GeneID; 562791; -.
DR CTD; 562791; -.
DR ZFIN; ZDB-GENE-100922-32; znf687a.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156524; -.
DR OMA; MESEDCQ; -.
DR OrthoDB; 180681at2759; -.
DR PRO; PR:A0A0R4IYX6; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 16.
DR Bgee; ENSDARG00000102774; Expressed in early embryo and 21 other tissues.
DR ExpressionAtlas; A0A0R4IYX6; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR045914; Zn532-like.
DR InterPro; IPR041697; Znf-C2H2_11.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR47222; PTHR47222; 3.
DR Pfam; PF00096; zf-C2H2; 3.
DR Pfam; PF16622; zf-C2H2_11; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1246
FT /note="Zinc finger protein 687a"
FT /id="PRO_0000437166"
FT ZN_FING 587..619
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 696..719
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 817..840
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 854..876
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 885..908
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 958..981
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 988..1011
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1018..1044
FT /note="C2H2-type 8; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1137..1160
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1210..1232
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 24..387
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 907..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1045..1093
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 89..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 121..135
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..201
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 268..301
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..321
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 342..360
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 929..947
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1046..1066
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1246 AA; 134592 MW; 93CF31FAA4A69579 CRC64;
MGDMKTPDFD DLLAAFDIPD IDAKEAIQSD THGNHNEHSS VVGKERSGSP SLRPSGSPDP
PHNDPSVVSV IVKNSVHSDD KAEGNETGEF SSADESQKSP QKGPSKDSSV PTDPFIYNGL
KSVSDGSTES PPSLDLAPGQ HNGPLWSLSA SKATGDDDKH NDAFTNHPAS TFQSLPLSNH
PSVSSHLISP NFSSKVDSEE AQAINGTLRA GVRRHQSEDE ESEPDLGSPA LVIQESPISQ
LCPAPKVPRM QRSPSSVFQP PSPSSPSLPV SNTQMEEPSV QHPKLHSSTN PTSLTSTNNL
PVEEKDLEHI IEERDSPESP EPEISQSRTS LPSNSQGAIE SKQRITREEA PQDEVMDVSM
QEKVDYGAEA TEGKSTEPTL VESASDAISN SASSKPLKMR IKTVKKPVVS ITRTVSKAAT
KGGASKGSGA SKVQAVARKS LQKIPRSVAS PQLLSQSTKV AMLPVSTLQD ASTAMLFAAS
RAQNQMPTAL SATAVNITRT SNLPSISSSS IPGVNVRAAS GQKTNTGTAK PASIVNSPGA
VISRSQSSLV EAFNKILNSK NPLPSYQPDL TSLPPPEWGL RLPSTGYRCL ECGDAFALER
SLARHYDRRS MRIEVTCNHC SKRLAFFNKC SLLLHAREHK EKGLVMQCSH LVMSPVSVEQ
MIGQQDTVPI GVLSPAVSAL SAIKESGVNL SQSSDHSCPE CWSTFKGKQE LVAHFQEVEP
GGTDTCCLQC SPPMPLWNSC CAAAHRRMHQ QLPPLVCPEC GLICQTHELN THLKQTCLHY
SRRLGYKCAC CHLVFGGVNS QNAVKTHMQT AHCEIFHKCP SCPMAFKSSS GAESHCASQH
PELSESARQS KEIYKCVMCR TVFTQKSLLS VHIDTHLTKQ KMHVFKCPDC NKLFTQRTSL
LEHVKDTHRE TSNHDGTSTQ NSLVKMESSD GEEWGRDEEE DKGKVSDANS AVPRSQSWSC
SQCQTHYTDK ENYISHMTEQ HGKELKKFPC TLCEGSFSSS SSLRRHIRVK HKGIKRVFYC
QLCTGEKRSF SSKLILEKHI QAQHAGERGT ATQSQAVPQF TDGADSSSEH DAGVLGGSSV
EPESRLAEST LTRRIKGAPV GEQEAKGLRC MPCGFTTEDR EEFLQHIVCH RDGGSGAQCQ
QCGACFASSS SLSRHLFISH RVRDSPSDHA EAALHTCATS VASDSAAAGG SPGSPLSVVG
GLLEDGEGKH ICKVCGRYFS KPADLNTHFR THGMAFITAY KTDKPA
