Z687B_DANRE
ID Z687B_DANRE Reviewed; 1431 AA.
AC F6NSX9;
DT 07-SEP-2016, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2016, sequence version 1.
DT 03-AUG-2022, entry version 32.
DE RecName: Full=Zinc finger protein 687b;
GN Name=znf687b; ORFNames=si:dkey-204a24.9;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen;
RX PubMed=23594743; DOI=10.1038/nature12111;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2]
RP TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RX PubMed=26849110; DOI=10.1016/j.ajhg.2015.12.016;
RA Divisato G., Formicola D., Esposito T., Merlotti D., Pazzaglia L.,
RA Del Fattore A., Siris E., Orcel P., Brown J.P., Nuti R., Strazzullo P.,
RA Benassi M.S., Cancela M.L., Michou L., Rendina D., Gennari L.,
RA Gianfrancesco F.;
RT "ZNF687 mutations in severe paget disease of bone associated with giant
RT cell tumor.";
RL Am. J. Hum. Genet. 98:275-286(2016).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q8N1G0}.
CC -!- TISSUE SPECIFICITY: Widely expressed with highest levels in eye, spleen
CC and ovary. {ECO:0000269|PubMed:26849110}.
CC -!- DEVELOPMENTAL STAGE: Highly expressed in the initial stages of
CC development (4-cell up to 1k-2k cell stages). Up-regulated during
CC regeneration of the caudal fin after amputation.
CC {ECO:0000269|PubMed:26849110}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; CR628394; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; F6NSX9; -.
DR STRING; 7955.ENSDARP00000123366; -.
DR PaxDb; F6NSX9; -.
DR Ensembl; ENSDART00000132336; ENSDARP00000123366; ENSDARG00000019299.
DR ZFIN; ZDB-GENE-041111-214; znf687b.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000156524; -.
DR OMA; TSWPGSD; -.
DR PhylomeDB; F6NSX9; -.
DR PRO; PR:F6NSX9; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 19.
DR Bgee; ENSDARG00000019299; Expressed in mature ovarian follicle and 22 other tissues.
DR ExpressionAtlas; F6NSX9; baseline.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR045914; Zn532-like.
DR InterPro; IPR041697; Znf-C2H2_11.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR47222; PTHR47222; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR Pfam; PF16622; zf-C2H2_11; 1.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1431
FT /note="Zinc finger protein 687b"
FT /id="PRO_0000437167"
FT ZN_FING 674..692
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 830..853
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 919..942
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 947..970
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 982..1004
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1013..1036
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1122..1145
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1205..1227
FT /note="C2H2-type 8; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1307..1329
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1337..1360
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 1395..1425
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 24..481
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 504..538
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 754..816
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1041..1120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1225..1310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1362..1392
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..76
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..155
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 220..267
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..326
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 338..361
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..381
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 385..405
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 411..452
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..470
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 754..807
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1043..1075
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1076..1114
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1281..1306
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1369..1383
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1431 AA; 152503 MW; 33C3F416D45396EB CRC64;
MGDMKTPDFD DLLAAFDIPD IDAKEAIQSA PDEVEGHQGA GGASLIKSGD ASVGESSALR
SPSPSTDSQS DPSIVSVIVK NRVRPEPFDG GENSVPDPLN HNGFVSSGGS VHMSQSRGQP
NGEQWPVCSS KAIPETAGQH GSSGGSKQGS NIFNKLKPLM AQGAGDSVGR ARKMQLLQQQ
HMQQEMNLEG ADKAKAPANP SGASGAASPF FPPPKPLLST PSTASSSSPS SSSPSVGSRV
SGAVASSPLA TSLTEPFNGT PRLSSSAFRR ADSEEEDSDP DSGGSLVIHE SPDSPTPPKL
SRRLRSSPEN SQSPSIPPST SISPNAYPKP GDVPSASPAS PRAQQNWLST AAQTGNGKSL
PQEERNPEHV IEERDSPESP EPEMPKSSMP TSAVTKRSCS PAAASSPSAA LREPKEEDEE
MEVDKASTEN GQDAENTDGG KGDTDKIEVD PAQSLEAETG SSTNSDGKAA TGGKAPSRPL
KVRIKTIKTS TGGITRTVTR VAGKGGAAAN AGKDANKGQT GGRAGPVKGG KKNDTTAGQG
VKCSTLPVST LEASSAMLAA ASKVQNKMTM QSDKTKVSAT AVSITKATTL PVAPAVGGIS
VRPTVGKTTN GGTMPCKPAS IVNSTGAVIS RSQSSLVEAF NKILNSKNLL PSYRPDLSTP
PPPEWGLPMP AAGYRCLECG DSFALERSLA RHYDRRSLRI EVTCNHCAKR LAFFNKCSLL
LHAREHKERG LVMQCSHLVM RPVTVEQMIG QQDTTPIGML SPSLSSPPLT SSTTPAGTIP
APSTSSPLKD SPSPGTASTQ PSPARRGPQS PQALMPLPCK KGEALQYHNF KCPECQAQFL
SKAELVTHFQ QIRATPNSTC TLCSPPMMLP NWCSVSAHQR IHKHRAPHVC PECGGTARQA
TFQTHLEESC LHFARRIGYR CSSCQVVFGG LNSIKSHIQT AHCEVFHKCP NCPMAFKSAQ
SAQGHITSQH PALTAAQAKM IYKCVMCDTV FTQKPLLYMH FDTHLAKQKV HVFKCPDCTK
LYAQKGSMME HIKTAHRGLS VKAETPPTTS SPVSAPAGNS TSKPKPATEN NSDELSQGPG
EEEEEGEDEE GEQEGEERED EEEEENEEEE QVSSPESGNM EWRCKECKKR FPEREDYIDH
MKNEHGTVGN EEISLQIVRA FIQFSQQSSS ACPNNTRGRQ ESLPLPVSRT LLNCKSGLKI
NKGSWHCSEG KRTFSSRLIL EKHIRVRHGI RSRQTTDRTN APNTRKRSLP ADGAGSSSEL
DNESGAPPAG GGTDTDDVPG EDTSGPAKRT RASENRPVEQ EEEDGTFRCT PCGFTTQDWE
EFQRHIPVHC DAENAPQQCL QCGACFASAG SLSRHKFITH RLRQGQHDRN ASPGASPQYG
SPSSPKAGED GDGGVSCRVC GRRFDKASDL NTHFRTHGMA FITAHRTDKP L
