Z703A_XENLA
ID Z703A_XENLA Reviewed; 534 AA.
AC Q7ZWN6;
DT 26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2007, sequence version 2.
DT 03-AUG-2022, entry version 71.
DE RecName: Full=Zinc finger protein 703-A;
GN Name=znf703-a;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP FUNCTION, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RX PubMed=28716930; DOI=10.1073/pnas.1704194114;
RA Li Y., Zhao D., Horie T., Chen G., Bao H., Chen S., Liu W., Horie R.,
RA Liang T., Dong B., Feng Q., Tao Q., Liu X.;
RT "Conserved gene regulatory module specifies lateral neural borders across
RT bilaterians.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:6352-6360(2017).
CC -!- FUNCTION: Transcriptional corepressor which does not bind directly to
CC DNA and may regulate transcription through recruitment of histone
CC deacetylases to gene promoters (By similarity). Regulates cell
CC adhesion, migration and proliferation (By similarity). Involved in
CC specification of the lateral neural plate border (NPB)
CC (PubMed:28716930). May be required for segmental gene expression during
CC hindbrain development (By similarity). {ECO:0000250|UniProtKB:Q9H7S9,
CC ECO:0000269|PubMed:28716930}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H7S9}. Cytoplasm
CC {ECO:0000250|UniProtKB:Q9H7S9}.
CC -!- DEVELOPMENTAL STAGE: Expressed at the posterior ectoderm except for the
CC dorsal midline in gastrulae (PubMed:28716930). During neurulation,
CC expression diminishes so as to become restricted to the lateral neural
CC plate border (NPB) and neural crest (PubMed:28716930).
CC {ECO:0000269|PubMed:28716930}.
CC -!- DISRUPTION PHENOTYPE: Morpholino knockdown blocks differentiation of
CC the neural plate border (NPB). {ECO:0000269|PubMed:28716930}.
CC -!- SIMILARITY: Belongs to the Elbow/Noc family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH46863.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; BC046863; AAH46863.1; ALT_INIT; mRNA.
DR RefSeq; XP_018108865.1; XM_018253376.1.
DR AlphaFoldDB; Q7ZWN6; -.
DR GeneID; 398562; -.
DR KEGG; xla:398562; -.
DR CTD; 398562; -.
DR Xenbase; XB-GENE-6256038; znf703.L.
DR OMA; PYYPHYT; -.
DR OrthoDB; 1163882at2759; -.
DR Proteomes; UP000186698; Chromosome 3L.
DR Bgee; 398562; Expressed in neurula embryo and 19 other tissues.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0016363; C:nuclear matrix; ISS:UniProtKB.
DR GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0034333; P:adherens junction assembly; ISS:UniProtKB.
DR GO; GO:0034111; P:negative regulation of homotypic cell-cell adhesion; ISS:UniProtKB.
DR GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR GO; GO:0030335; P:positive regulation of cell migration; ISS:UniProtKB.
DR GO; GO:0060828; P:regulation of canonical Wnt signaling pathway; ISS:UniProtKB.
DR GO; GO:0051726; P:regulation of cell cycle; ISS:UniProtKB.
DR GO; GO:0017015; P:regulation of transforming growth factor beta receptor signaling pathway; ISS:UniProtKB.
DR InterPro; IPR022129; Tscrpt_rep_NocA-like.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF12402; nlz1; 1.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Developmental protein; Metal-binding; Nucleus;
KW Reference proteome; Repressor; Transcription; Transcription regulation;
KW Zinc; Zinc-finger.
FT CHAIN 1..534
FT /note="Zinc finger protein 703-A"
FT /id="PRO_0000292209"
FT ZN_FING 406..434
FT /note="C2H2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 90..251
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..26
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..124
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..202
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 203..242
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 534 AA; 55512 MW; B9370EE3563EC345 CRC64;
MNCSPPGSST DTERQSSSSG TPATPCPTLA PTHPVRQANR LPIRLINMLT AHTGHLLHPE
YLQPLSSTPI SPIELDAKKS PLALLAQTCS QIGKPDPPPS SKLNSVTSSE KESGRSSSLK
LGESPLEDKS SFKPYSKGGE TRKESGSSAG GSADKAGFRV PSGSCQPFPH APSPSSRVSS
PGQHCDSKNN ESQEKKEPEA NKGSLETSQA NPTLTRASIS NSSAESSQSG DVTPSSKSDP
PSLGSGHVAP VSPYKPGHSV FPLPPSGIGY HGSIVGAYAG YPSQYVHGLD HTKTSLVGNQ
LPGTLGLPGK PPSSSPLTGA SPPSFMQGLC RDPYCLSYHN ASHLGSSSCS TCVHDPSALK
SGYPLVYPSH PLHSVHTTMS SSVTPSLSGH PLYTYGFMLQ NDPVPHICNW VSASGPCDKR
FATSEELLAH LRTHTALPGA DKLLAGYPTS SFGSAASCHL HLPPGGPGSP TTLPGSLSLR
SPHTLGLSRY HPYGKGHLTT PSGLPVPSLP AGSYYSPYAL YGQRLTSASA LGYQ
