Z705A_HUMAN
ID Z705A_HUMAN Reviewed; 300 AA.
AC Q6ZN79;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Zinc finger protein 705A;
GN Name=ZNF705A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK131339; BAD18496.1; -; mRNA.
DR CCDS; CCDS31737.1; -.
DR RefSeq; NP_001004328.1; NM_001004328.2.
DR AlphaFoldDB; Q6ZN79; -.
DR SMR; Q6ZN79; -.
DR STRING; 9606.ENSP00000352233; -.
DR iPTMnet; Q6ZN79; -.
DR PhosphoSitePlus; Q6ZN79; -.
DR BioMuta; ZNF705A; -.
DR DMDM; 74758719; -.
DR MassIVE; Q6ZN79; -.
DR PaxDb; Q6ZN79; -.
DR PeptideAtlas; Q6ZN79; -.
DR PRIDE; Q6ZN79; -.
DR DNASU; 440077; -.
DR Ensembl; ENST00000359286.4; ENSP00000352233.4; ENSG00000196946.10.
DR Ensembl; ENST00000610508.4; ENSP00000481663.1; ENSG00000196946.10.
DR GeneID; 440077; -.
DR KEGG; hsa:440077; -.
DR UCSC; uc001qud.2; human.
DR CTD; 440077; -.
DR DisGeNET; 440077; -.
DR GeneCards; ZNF705A; -.
DR HGNC; HGNC:32281; ZNF705A.
DR HPA; ENSG00000196946; Tissue enhanced (brain).
DR neXtProt; NX_Q6ZN79; -.
DR OpenTargets; ENSG00000196946; -.
DR PharmGKB; PA142670502; -.
DR VEuPathDB; HostDB:ENSG00000196946; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163626; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; Q6ZN79; -.
DR OMA; HERTHHG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZN79; -.
DR TreeFam; TF338497; -.
DR PathwayCommons; Q6ZN79; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6ZN79; -.
DR BioGRID-ORCS; 440077; 26 hits in 1010 CRISPR screens.
DR ChiTaRS; ZNF705A; human.
DR GenomeRNAi; 440077; -.
DR Pharos; Q6ZN79; Tdark.
DR PRO; PR:Q6ZN79; -.
DR Proteomes; UP000005640; Chromosome 12.
DR RNAct; Q6ZN79; protein.
DR Bgee; ENSG00000196946; Expressed in left testis and 28 other tissues.
DR ExpressionAtlas; Q6ZN79; baseline and differential.
DR GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..300
FT /note="Zinc finger protein 705A"
FT /id="PRO_0000233283"
FT DOMAIN 7..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 172..194
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..250
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 126
FT /note="T -> A (in dbSNP:rs10743251)"
FT /id="VAR_059929"
FT VARIANT 134
FT /note="R -> C (in dbSNP:rs10743252)"
FT /id="VAR_059930"
FT VARIANT 142
FT /note="K -> Q (in dbSNP:rs10743253)"
FT /id="VAR_033595"
FT VARIANT 186
FT /note="R -> H (in dbSNP:rs11043758)"
FT /id="VAR_059931"
SQ SEQUENCE 300 AA; 34734 MW; 88D49C592D7D8AA7 CRC64;
MHSLKKVTFE DVAIDFTQEE WAMMDTSKRK LYRDVMLENI SHLVSLGYQI SKSYIILQLE
QGKELWREGR EFLQDQNPDR ESALKKKHMI SMHPITRKDA STSMTMENSL ILEDPFECND
SGEDCTHSST ITQRLLTHSG KKPYVSKQCG KSLRNLFSPK PHKQIHTKGK SYQCNLCEKA
YTNCFRLRRH KMTHTGERPY ACHLCGKAFT QCSHLRRHEK THTGERPYKC HQCGKAFIQS
FNLRRHERTH LGKKCYECDK SGKAFSQSSG FRGNKIIHTG EKPHACLLCG KAFSLSSDLR
