Z705D_HUMAN
ID Z705D_HUMAN Reviewed; 300 AA.
AC P0CH99; A8K971; A8MY01; Q2TAN0;
DT 05-OCT-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-OCT-2010, sequence version 1.
DT 03-AUG-2022, entry version 87.
DE RecName: Full=Zinc finger protein 705D;
GN Name=ZNF705D;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC P0CH99; Q96NT3-2: GUCD1; NbExp=3; IntAct=EBI-12957159, EBI-11978177;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC130366; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC110823; AAI10824.1; -; mRNA.
DR CCDS; CCDS43712.1; -.
DR RefSeq; NP_001034704.2; NM_001039615.3.
DR RefSeq; XP_011542134.1; XM_011543832.2.
DR AlphaFoldDB; P0CH99; -.
DR SMR; P0CH99; -.
DR BioGRID; 609366; 1.
DR IntAct; P0CH99; 1.
DR BioMuta; ZNF705D; -.
DR DMDM; 308191622; -.
DR MassIVE; P0CH99; -.
DR PaxDb; P0CH99; -.
DR PeptideAtlas; P0CH99; -.
DR PRIDE; P0CH99; -.
DR Antibodypedia; 58562; 18 antibodies from 6 providers.
DR DNASU; 728957; -.
DR Ensembl; ENST00000400078.3; ENSP00000445477.2; ENSG00000215343.7.
DR Ensembl; ENST00000400085.7; ENSP00000382957.3; ENSG00000215343.7.
DR GeneID; 728957; -.
DR KEGG; hsa:728957; -.
DR MANE-Select; ENST00000400085.8; ENSP00000382957.3; NM_001039615.3; NP_001034704.2.
DR UCSC; uc064kiq.1; human.
DR CTD; 728957; -.
DR GeneCards; ZNF705D; -.
DR HGNC; HGNC:33202; ZNF705D.
DR HPA; ENSG00000215343; Tissue enriched (epididymis).
DR neXtProt; NX_P0CH99; -.
DR OpenTargets; ENSG00000215343; -.
DR VEuPathDB; HostDB:ENSG00000215343; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163626; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; P0CH99; -.
DR OMA; PFISKQC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; P0CH99; -.
DR TreeFam; TF338497; -.
DR PathwayCommons; P0CH99; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; P0CH99; -.
DR BioGRID-ORCS; 728957; 157 hits in 968 CRISPR screens.
DR ChiTaRS; ZNF705D; human.
DR GenomeRNAi; 728957; -.
DR Pharos; P0CH99; Tdark.
DR PRO; PR:P0CH99; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; P0CH99; protein.
DR Bgee; ENSG00000215343; Expressed in prefrontal cortex and 8 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..300
FT /note="Zinc finger protein 705D"
FT /id="PRO_0000332236"
FT DOMAIN 7..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 172..194
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..250
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 256..278
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 144
FT /note="C -> Y (in Ref. 2; AAI10824)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 300 AA; 34712 MW; 1E1C943AF352977B CRC64;
MHSLEKVTFE DVAIDFTQEE WDMMDTSKRK LYRDVMLENI SHLVSLGYQI SKSYIILQLE
QGKELWREGR VFLQDQNPDR ESALKKKHMI SMHPIIRKDA STSMTMENSL ILEDPFEYND
SGEDCTHSST ITQCLLTHSG KKPCVSKQCG KSLRNLLSPK PRKQIHTKGK SYQCNLCEKA
YTNCFYLRRH KMTHTGERPY ACHLCGKAFT QCSHLRRHEK THTGERPYKC HQCGKAFIQS
FNLRRHERTH LGQKCYECDK SGKAFSQSSG FRGNKIIHIG EKPHACLLCG KAFSLSSDLR
