ID   Z705E_HUMAN             Reviewed;         300 AA.
AC   A8MWA4; A0A1W2PRR0;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   28-MAR-2018, sequence version 2.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=Putative zinc finger protein 705EP {ECO:0000305};
DE   AltName: Full=zinc finger protein 705E pseudogene {ECO:0000312|HGNC:HGNC:33203};
GN   Name=ZNF705EP {ECO:0000312|HGNC:HGNC:33203};
GN   Synonyms=ZNF705E {ECO:0000312|HGNC:HGNC:33203};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16554811; DOI=10.1038/nature04632;
RA   Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K.,
RA   Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T.,
RA   Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G.,
RA   Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C.,
RA   Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A.,
RA   Hattori M., Rogers J., Lander E.S., Sakaki Y.;
RT   "Human chromosome 11 DNA sequence and analysis including novel gene
RT   identification.";
RL   Nature 440:497-500(2006).
CC   -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR   EMBL; AP002495; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; NP_001265642.1; NM_001278713.1.
DR   AlphaFoldDB; A8MWA4; -.
DR   SMR; A8MWA4; -.
DR   PhosphoSitePlus; A8MWA4; -.
DR   BioMuta; ZNF705E; -.
DR   MassIVE; A8MWA4; -.
DR   PeptideAtlas; A8MWA4; -.
DR   PRIDE; A8MWA4; -.
DR   ProteomicsDB; 2234; -.
DR   DNASU; 100131539; -.
DR   Ensembl; ENST00000525199.1; ENSP00000492790.1; ENSG00000214534.5.
DR   GeneID; 100131539; -.
DR   CTD; 100131539; -.
DR   GeneCards; ZNF705E; -.
DR   HGNC; HGNC:33203; ZNF705EP.
DR   HPA; ENSG00000214534; Not detected.
DR   neXtProt; NX_A8MWA4; -.
DR   OpenTargets; ENSG00000214534; -.
DR   VEuPathDB; HostDB:ENSG00000214534; -.
DR   GeneTree; ENSGT00940000163626; -.
DR   InParanoid; A8MWA4; -.
DR   OMA; IQCLLTH; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; A8MWA4; -.
DR   PathwayCommons; A8MWA4; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   GenomeRNAi; 100131539; -.
DR   Pharos; A8MWA4; Tdark.
DR   PRO; PR:A8MWA4; -.
DR   Proteomes; UP000005640; Chromosome 11.
DR   RNAct; A8MWA4; protein.
DR   Bgee; ENSG00000214534; Expressed in calcaneal tendon and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 4.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   5: Uncertain;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..300
FT                   /note="Putative zinc finger protein 705EP"
FT                   /id="PRO_0000343575"
FT   DOMAIN          7..78
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         172..194
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         200..222
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         228..250
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         256..278
FT                   /note="C2H2-type 4; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ   SEQUENCE   300 AA;  34697 MW;  C4F496956EF00C6E CRC64;
     MHSLKKVTFE DVAIDFTQEE WAMMDTSKRK LYRDVMLENI SHLVSLGYQI SKSYIILQLE
     QGKELWQEGR EFLQDQNPDR ESALKKTHMI SMHPIIRKDA PTSMTMENSL ILEDPFECND
     SGEDCTHSST IIQCLLTHSG KKPYVSKQCG KSLSNLLSPK PHKQIHTKGK SYQCNLCEKA
     YTNCFHLRRP KMTHTGERPY TCHLCRKAFT QCSHLRRHEK THTGERPYKC HQCGKAFIQS
     FNLRRHERTH LGEKWYECDN SGKAFSQSSG FRGNKIIHTG EKPHACLLCG KAFSLSSDLR