Z705G_HUMAN
ID Z705G_HUMAN Reviewed; 300 AA.
AC A8MUZ8;
DT 01-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Putative zinc finger protein 705G;
GN Name=ZNF705G;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16421571; DOI=10.1038/nature04406;
RA Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M.,
RA Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L.,
RA Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S.,
RA Asakawa T., Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A.,
RA Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III,
RA Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K.,
RA Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P.,
RA Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H.,
RA Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B.,
RA O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K.,
RA Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L.,
RA Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G.,
RA Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W.,
RA Platzer M., Shimizu N., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 8.";
RL Nature 439:331-335(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-169.
RG The Cancer Genome Anatomy Project (CGAP) at the National Cancer Institute;
RL Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC130360; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BE466749; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS47773.1; -.
DR RefSeq; NP_001157929.1; NM_001164457.1.
DR RefSeq; XP_016868430.1; XM_017012941.1.
DR RefSeq; XP_016868431.1; XM_017012942.1.
DR AlphaFoldDB; A8MUZ8; -.
DR SMR; A8MUZ8; -.
DR BioGRID; 573352; 1.
DR STRING; 9606.ENSP00000383020; -.
DR iPTMnet; A8MUZ8; -.
DR PhosphoSitePlus; A8MUZ8; -.
DR BioMuta; ZNF705G; -.
DR MassIVE; A8MUZ8; -.
DR MaxQB; A8MUZ8; -.
DR PaxDb; A8MUZ8; -.
DR PeptideAtlas; A8MUZ8; -.
DR PRIDE; A8MUZ8; -.
DR Antibodypedia; 76320; 3 antibodies from 3 providers.
DR DNASU; 100131980; -.
DR Ensembl; ENST00000400156.4; ENSP00000383020.4; ENSG00000215372.6.
DR GeneID; 100131980; -.
DR KEGG; hsa:100131980; -.
DR MANE-Select; ENST00000400156.4; ENSP00000383020.4; NM_001164457.3; NP_001157929.1.
DR UCSC; uc033bav.2; human.
DR CTD; 100131980; -.
DR DisGeNET; 100131980; -.
DR GeneCards; ZNF705G; -.
DR HGNC; HGNC:37134; ZNF705G.
DR HPA; ENSG00000215372; Not detected.
DR neXtProt; NX_A8MUZ8; -.
DR OpenTargets; ENSG00000215372; -.
DR PharmGKB; PA165586029; -.
DR VEuPathDB; HostDB:ENSG00000215372; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163626; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; A8MUZ8; -.
DR OMA; EHNDSGE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; A8MUZ8; -.
DR TreeFam; TF338497; -.
DR PathwayCommons; A8MUZ8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; A8MUZ8; -.
DR BioGRID-ORCS; 100131980; 101 hits in 914 CRISPR screens.
DR GenomeRNAi; 100131980; -.
DR Pharos; A8MUZ8; Tdark.
DR PRO; PR:A8MUZ8; -.
DR Proteomes; UP000005640; Chromosome 8.
DR RNAct; A8MUZ8; protein.
DR Bgee; ENSG00000215372; Expressed in right testis and 1 other tissue.
DR Genevisible; A8MUZ8; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..300
FT /note="Putative zinc finger protein 705G"
FT /id="PRO_0000342396"
FT DOMAIN 7..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 172..194
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..250
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 256..278
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 300 AA; 34765 MW; FACCC34A68841184 CRC64;
MHSLKKLTFE DVAIDFTQEE WAMMDTSKRK LYRDVMLENI SHLVSLGYQI SKSYIILQLE
QGKELWREGR VFLQDQNPNR ESALKKTHMI SMHPITRKDA STSMTMENSL ILEDPFECND
SGEDCTRSST ITQCLLTHSG KKPYVSKQCG KSLRNLLSTE PHKQIHTKGK SYQCNLCEKA
YTNCFHLRRH KMTHTGERPY ACHLCRKAFT QCSHLRRHEK THTGQRPYKC HQYGKVFIQS
FNLQRHERTH LGKKCYECDK SGKAFSQSSG FRGNKIIHTG EKPHACLLCG KAFSLSSNLR
