Z780B_HUMAN
ID Z780B_HUMAN Reviewed; 833 AA.
AC Q9Y6R6; B9EH00;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Zinc finger protein 780B;
DE AltName: Full=Zinc finger protein 779;
GN Name=ZNF780B; Synonyms=ZNF779;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC007842; AAD39268.1; -; Genomic_DNA.
DR EMBL; CH471126; EAW56932.1; -; Genomic_DNA.
DR EMBL; BC136960; AAI36961.1; -; mRNA.
DR CCDS; CCDS46077.1; -.
DR RefSeq; NP_001005851.1; NM_001005851.2.
DR RefSeq; XP_005258650.1; XM_005258593.2.
DR RefSeq; XP_016881914.1; XM_017026425.1.
DR RefSeq; XP_016881915.1; XM_017026426.1.
DR RefSeq; XP_016881916.1; XM_017026427.1.
DR AlphaFoldDB; Q9Y6R6; -.
DR SMR; Q9Y6R6; -.
DR IntAct; Q9Y6R6; 1.
DR STRING; 9606.ENSP00000391641; -.
DR iPTMnet; Q9Y6R6; -.
DR PhosphoSitePlus; Q9Y6R6; -.
DR BioMuta; ZNF780B; -.
DR DMDM; 74762083; -.
DR jPOST; Q9Y6R6; -.
DR MassIVE; Q9Y6R6; -.
DR MaxQB; Q9Y6R6; -.
DR PaxDb; Q9Y6R6; -.
DR PeptideAtlas; Q9Y6R6; -.
DR PRIDE; Q9Y6R6; -.
DR Antibodypedia; 839; 97 antibodies from 17 providers.
DR DNASU; 163131; -.
DR Ensembl; ENST00000434248.6; ENSP00000391641.1; ENSG00000128000.17.
DR Ensembl; ENST00000625684.3; ENSP00000487572.1; ENSG00000281601.5.
DR Ensembl; ENST00000678949.1; ENSP00000503959.1; ENSG00000281601.5.
DR GeneID; 163131; -.
DR KEGG; hsa:163131; -.
DR MANE-Select; ENST00000434248.6; ENSP00000391641.1; NM_001005851.3; NP_001005851.1.
DR UCSC; uc002omu.3; human.
DR CTD; 163131; -.
DR DisGeNET; 163131; -.
DR GeneCards; ZNF780B; -.
DR HGNC; HGNC:33109; ZNF780B.
DR HPA; ENSG00000128000; Low tissue specificity.
DR neXtProt; NX_Q9Y6R6; -.
DR OpenTargets; ENSG00000128000; -.
DR PharmGKB; PA162410426; -.
DR VEuPathDB; HostDB:ENSG00000128000; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164600; -.
DR InParanoid; Q9Y6R6; -.
DR OMA; AFRHQYQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9Y6R6; -.
DR TreeFam; TF343410; -.
DR PathwayCommons; Q9Y6R6; -.
DR SignaLink; Q9Y6R6; -.
DR BioGRID-ORCS; 163131; 10 hits in 1103 CRISPR screens.
DR GenomeRNAi; 163131; -.
DR Pharos; Q9Y6R6; Tdark.
DR PRO; PR:Q9Y6R6; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9Y6R6; protein.
DR Bgee; ENSG00000128000; Expressed in corpus callosum and 103 other tissues.
DR ExpressionAtlas; Q9Y6R6; baseline and differential.
DR Genevisible; Q9Y6R6; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 23.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 21.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 23.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..833
FT /note="Zinc finger protein 780B"
FT /id="PRO_0000263088"
FT DOMAIN 6..77
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 165..187
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 193..215
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 221..243
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 249..271
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 277..299
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 305..327
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 333..355
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 361..383
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 389..411
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 417..439
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 445..467
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 473..495
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 501..523
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 529..551
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 557..579
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 585..607
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 613..635
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 641..663
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 669..691
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 697..719
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 725..747
FT /note="C2H2-type 21"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 753..775
FT /note="C2H2-type 22; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 781..803
FT /note="C2H2-type 23; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 833 AA; 96807 MW; 2A354BA8B633B54A CRC64;
MVHGSVTFRD VAIDFSQEEW ECLQPDQRTL YRDVMLENYS HLISLGSSIS KPDVITLLEQ
EKEPWIVVSK ETSRWYPDLE SKYGPEKISP ENDIFEINLP KHVIKQISKT LGLEAFYFRN
DSEYRSRFEG RQGHQEGYIN QKIISYEEMP AYTHASPIHN THKPYECKEC GKYFSCGSNL
IQHQSIHTGE KPYKCKECGK AFQLHIQLTR HQKFHTGEKT FECKECGKAF NLPTQLNRHK
NIHTVKKLFE CKECGKSFNR SSNLTQHQSI HAGVKPYQCK ECGKAFNRGS NLIQHQKIHS
NEKPFVCREC EMAFRYHYQL IEHCRIHTGE KPFECKECRK AFTLLTKLVR HQKIHMGEKP
FECRECGKAF SLLNQLNRHK NIHTGEKPFE CKECGKSFNR SSNLIQHQSI HADVKPYECK
ECGKGFNRGA NLIQHQKIHS NEKPFVCREC EMAFRYHYQL IQHCQIHTGG KPFECKECGK
AFSLLTQLAR HKNIHTGEKP FECKDCGKAF NRGSNLVQHQ SIHTGEKPYE CKECGKAFRL
HLQLSQHEKT HTGEKPFECK ECGKFFRRGS NLNQHRSIHT GKKPFECKEC GKAFRLHMHL
IRHQKFHTGE KPFECKECGK AFSLHTQLNH HKNIHTGEKP FKCKECGKSF NRVSNLVQHQ
SIHAGVKPYE CKECGKGFSR VSNLIQHQKT HSSAKPFVCK ECRKTFRYHY QLTEHYRIHT
GEKPFECKEC GKAFGLLTQL AQHQIIHTGE KPFKCKECGK AFNRGSNLVQ PQSIHTGEKP
YECKECGKAF RLHLQLSLHQ KLVQVRNPLN VRNVGQPSDI SSNLLNIRKF ILG
