Z804B_HUMAN
ID Z804B_HUMAN Reviewed; 1349 AA.
AC A4D1E1; B2RTV2; Q7Z714; Q96MN7;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 102.
DE RecName: Full=Zinc finger protein 804B;
GN Name=ZNF804B;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Shan Y.X., Huang C.Q., Yu L.;
RL Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ILE-634.
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-600.
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [6]
RP VARIANT TYR-248.
RX PubMed=20547088; DOI=10.1016/j.legalmed.2010.04.001;
RA Yuasa I., Umetsu K., Matsusue A., Nishimukai H., Harihara S., Fukumori Y.,
RA Saitou N., Jin F., Chattopadhyay P.K., Henke L., Henke J.;
RT "A Japanese-specific allele in the GALNT11 gene.";
RL Leg. Med. 12:208-211(2010).
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DR EMBL; AY295769; AAP49447.1; -; mRNA.
DR EMBL; AC002127; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC002382; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC006350; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236949; EAL24168.1; -; Genomic_DNA.
DR EMBL; BC140826; AAI40827.1; -; mRNA.
DR EMBL; BC140829; AAI40830.1; -; mRNA.
DR EMBL; AK056672; BAB71248.1; -; mRNA.
DR CCDS; CCDS5613.1; -.
DR RefSeq; NP_857597.1; NM_181646.3.
DR AlphaFoldDB; A4D1E1; -.
DR SMR; A4D1E1; -.
DR BioGRID; 128555; 3.
DR IntAct; A4D1E1; 1.
DR STRING; 9606.ENSP00000329638; -.
DR GlyGen; A4D1E1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; A4D1E1; -.
DR PhosphoSitePlus; A4D1E1; -.
DR BioMuta; ZNF804B; -.
DR EPD; A4D1E1; -.
DR jPOST; A4D1E1; -.
DR MassIVE; A4D1E1; -.
DR MaxQB; A4D1E1; -.
DR PaxDb; A4D1E1; -.
DR PeptideAtlas; A4D1E1; -.
DR PRIDE; A4D1E1; -.
DR ProteomicsDB; 614; -.
DR Antibodypedia; 15392; 20 antibodies from 9 providers.
DR DNASU; 219578; -.
DR Ensembl; ENST00000333190.5; ENSP00000329638.4; ENSG00000182348.7.
DR GeneID; 219578; -.
DR KEGG; hsa:219578; -.
DR MANE-Select; ENST00000333190.5; ENSP00000329638.4; NM_181646.5; NP_857597.1.
DR UCSC; uc011khi.3; human.
DR CTD; 219578; -.
DR DisGeNET; 219578; -.
DR GeneCards; ZNF804B; -.
DR HGNC; HGNC:21958; ZNF804B.
DR HPA; ENSG00000182348; Tissue enhanced (brain, thyroid gland).
DR neXtProt; NX_A4D1E1; -.
DR OpenTargets; ENSG00000182348; -.
DR PharmGKB; PA162410600; -.
DR VEuPathDB; HostDB:ENSG00000182348; -.
DR eggNOG; ENOG502QS70; Eukaryota.
DR GeneTree; ENSGT00940000160479; -.
DR HOGENOM; CLU_005858_0_0_1; -.
DR InParanoid; A4D1E1; -.
DR OMA; QGQDLCH; -.
DR OrthoDB; 332880at2759; -.
DR PhylomeDB; A4D1E1; -.
DR TreeFam; TF332138; -.
DR PathwayCommons; A4D1E1; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; A4D1E1; -.
DR BioGRID-ORCS; 219578; 6 hits in 1064 CRISPR screens.
DR ChiTaRS; ZNF804B; human.
DR GenomeRNAi; 219578; -.
DR Pharos; A4D1E1; Tdark.
DR PRO; PR:A4D1E1; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; A4D1E1; protein.
DR Bgee; ENSG00000182348; Expressed in left lobe of thyroid gland and 14 other tissues.
DR ExpressionAtlas; A4D1E1; baseline and differential.
DR Genevisible; A4D1E1; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR022755; Znf_C2H2_jaz.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF12171; zf-C2H2_jaz; 1.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE 2: Evidence at transcript level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..1349
FT /note="Zinc finger protein 804B"
FT /id="PRO_0000289140"
FT ZN_FING 55..79
FT /note="C2H2-type"
FT REGION 985..1010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 995..1009
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 248
FT /note="C -> Y (in dbSNP:rs1916830)"
FT /evidence="ECO:0000269|PubMed:20547088"
FT /id="VAR_054666"
FT VARIANT 634
FT /note="F -> I (in dbSNP:rs801840)"
FT /evidence="ECO:0000269|PubMed:12690205"
FT /id="VAR_059938"
FT VARIANT 909
FT /note="E -> K (in dbSNP:rs10487075)"
FT /id="VAR_054667"
FT VARIANT 914
FT /note="N -> H (in dbSNP:rs59859857)"
FT /id="VAR_061968"
FT VARIANT 915
FT /note="T -> I (in dbSNP:rs56948780)"
FT /id="VAR_061969"
FT VARIANT 1105
FT /note="M -> V (in dbSNP:rs6963781)"
FT /id="VAR_054668"
FT VARIANT 1195
FT /note="V -> I (in dbSNP:rs801841)"
FT /id="VAR_054669"
FT CONFLICT 144
FT /note="K -> E (in Ref. 5; BAB71248)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1349 AA; 152573 MW; 8A5E69A1F0536DFC CRC64;
MACYLVISSR HLSNGHYRGI KGVFRGPLCK NGSPSPDFAE KKSTAKALED VKANFYCELC
DKQYHKHQEF DNHINSYDHA HKQRLKELKQ REFARNVASK SWKDEKKQEK ALKRLHQLAE
LRQQSECVSG NGPAYKAPRV AIEKQLQQGI FPIKNGRKVS CMKSALLLKG KNLPRIISDK
QRSTMPNRHQ LQSDRRCLFG NQVLQTSSDL SNANHRTGVS FTFSKKVHLK LESSASVFSE
NTEETHDCNK SPIYKTKQTA DKCKCCRFAN KDTHLTKEKE VNISPSHLES VLHNTISINS
KILQDKHDSI DETLEDSIGI HASFSKSNIH LSDVDFTPTS REKETRNTLK NTLENCVNHP
CQANASFSPP NIYNHSDARI SECLDEFSSL EPSEQKSTVH LNPNSRIENR EKSLDKTERV
SKNVQRLVKE ACTHNVASKP LPFLHVQSKD GHTTLQWPTE LLLFTKTEPC ISYGCNPLYF
DFKLSRNTKE DHNLEDLKTE LGKKPLELKT KRESQVSGLT EDQQKLIQED YQYPKPKTMI
ANPDWEKFQR KYNLDYSDSE PNKSEYTFSA NDLEMKNPKV PLYLNTSLKD CAGKNNSSEN
KLKEASRAHW QGCRKAVLND IDEDLSFPSY ISRFKKHKLI PCSPHLEFED ERQFNCKSSP
CTVGGHSDHG KDFSVILKSN HISMTSKVSG CGNQRYKRYS PQSCLSRYSS SLDTSPSSMS
SLRSTCSSHR FNGNSRGNLL CFHKREHHSV ERHKRKCLKH NCFYLSDDIT KSSQMQSEPQ
KERNCKLWES FKNEKYSKRR YCHCRERQKL GKNQQQFSGL KSTRIIYCDS NSQISCTGSS
KKPPNCQGTQ HDRLDSYSIE KMYYLNKSKR NQESLGSPHI CDLGKVRPMK CNSGNISCLL
KNCSSGPSET TESNTAEGER TPLTAKILLE RVQAKKCQEQ SSNVEISSNS CKSELEAPSQ
VPCTIQLAPS GCNRQALPLS EKIQYASESR NDQDSAIPRT TEKDKSKSSH TNNFTILADT
DCDNHLSKGI IHLVTESQSL NIKRDATTKE QSKPLISEIQ PFIQSCDPVP NEFPGAFPSN
KYTGVTDSTE TQEDQINLDL QDVSMHINHV EGNINSYYDR TMQKPDKVED GLEMCHKSIS
PPLIQQPITF SPDEIDKYKI LQLQAQQHMQ KQLLSKHLRV LPAAGPTAFS PASTVQTVPV
HQHTSITTIH HTFLQHFAVS ASLSSHSSHL PIAHLHPLSQ AHFSPISFST LTPTIIPAHP
TFLAGHPLHL VAATPFHPSH ITLQPLPPTA FIPTLFGPHL NPATTSIIHL NPLIQPVFQG
QDFCHHSCSS QMQQLNEVKE ALNVSTHLN
