ZA2G_BOVIN
ID ZA2G_BOVIN Reviewed; 299 AA.
AC Q3ZCH5;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Zinc-alpha-2-glycoprotein;
DE Short=Zn-alpha-2-GP;
DE Short=Zn-alpha-2-glycoprotein;
DE Flags: Precursor;
GN Name=AZGP1;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Hereford; TISSUE=Mammary gland;
RG NIH - Mammalian Gene Collection (MGC) project;
RL Submitted (AUG-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Stimulates lipid degradation in adipocytes and causes the
CC extensive fat losses associated with some advanced cancers.
CC {ECO:0000250}.
CC -!- SUBUNIT: Interacts with PIP. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the MHC class I family. {ECO:0000305}.
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DR EMBL; BC102237; AAI02238.1; -; mRNA.
DR RefSeq; NP_001029503.1; NM_001034331.1.
DR AlphaFoldDB; Q3ZCH5; -.
DR SMR; Q3ZCH5; -.
DR STRING; 9913.ENSBTAP00000037042; -.
DR PaxDb; Q3ZCH5; -.
DR PeptideAtlas; Q3ZCH5; -.
DR PRIDE; Q3ZCH5; -.
DR GeneID; 508800; -.
DR KEGG; bta:508800; -.
DR CTD; 563; -.
DR eggNOG; ENOG502RWW3; Eukaryota.
DR HOGENOM; CLU_047501_0_1_1; -.
DR InParanoid; Q3ZCH5; -.
DR OrthoDB; 912212at2759; -.
DR TreeFam; TF336617; -.
DR Proteomes; UP000009136; Unplaced.
DR GO; GO:0009897; C:external side of plasma membrane; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0002476; P:antigen processing and presentation of endogenous peptide antigen via MHC class Ib; IBA:GO_Central.
DR Gene3D; 2.60.40.10; -; 1.
DR Gene3D; 3.30.500.10; -; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011161; MHC_I-like_Ag-recog.
DR InterPro; IPR037055; MHC_I-like_Ag-recog_sf.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR001039; MHC_I_a_a1/a2.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00129; MHC_I; 1.
DR PRINTS; PR01638; MHCCLASSI.
DR SMART; SM00407; IGc1; 1.
DR SUPFAM; SSF48726; SSF48726; 1.
DR SUPFAM; SSF54452; SSF54452; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 2: Evidence at transcript level;
KW Disulfide bond; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..17
FT /evidence="ECO:0000255"
FT CHAIN 18..299
FT /note="Zinc-alpha-2-glycoprotein"
FT /id="PRO_0000317709"
FT DOMAIN 204..289
FT /note="Ig-like C1-type"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 125
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 120..183
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
FT DISULFID 222..277
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00114"
SQ SEQUENCE 299 AA; 33852 MW; 55A2D1179A8FDB54 CRC64;
MVPVLLALLL LLGPAVSEET QAGNYSLSFL YTGLSKPREG FPSFQAVAYL NDQPFFHYNS
EGRRAEPLAP WSQVEGMEDW EKESALQRAR EDIFMETLSD IMDYYKDREG SHTFQGAFGC
ELRNNESSGA FWGYAYDGQD FIKFDKEIPA WVPLDPAAQN TKRKWEAEAV YVQRAKAYLE
EECPGMLRRY LPYSRTHLDR QESPSVSVTG HAAPGHKRTL KCLAYDFYPR SIGLHWTRAG
DAQEAESGGD VLPSGNGTYQ SWVVVGVPPE DQAPYSCHVE HRSLTRPLTV PWDPRQQAE
