ID   CC125_DANRE             Reviewed;         465 AA.
AC   A2BGP7;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Coiled-coil domain-containing protein 125;
GN   Name=ccdc125; ORFNames=si:ch211-244p18.4;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen;
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA   Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA   Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA   White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA   Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA   Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA   Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J., Clark S.,
RA   Pelan S., Griffiths G., Smith M., Glithero R., Howden P., Barker N.,
RA   Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G., Lovell J.,
RA   Beasley H., Henderson C., Gordon D., Auger K., Wright D., Collins J.,
RA   Raisen C., Dyer L., Leung K., Robertson L., Ambridge K., Leongamornlert D.,
RA   McGuire S., Gilderthorp R., Griffiths C., Manthravadi D., Nichol S.,
RA   Barker G., Whitehead S., Kay M., Brown J., Murnane C., Gray E.,
RA   Humphries M., Sycamore N., Barker D., Saunders D., Wallis J., Babbage A.,
RA   Hammond S., Mashreghi-Mohammadi M., Barr L., Martin S., Wray P.,
RA   Ellington A., Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D., Bird C.,
RA   Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z., Eser C.,
RA   Geiger H., Geisler M., Karotki L., Kirn A., Konantz J., Konantz M.,
RA   Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G.,
RA   Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C., Yang F.,
RA   Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J., Searle S.M.,
RA   Enright A., Geisler R., Plasterk R.H., Lee C., Westerfield M.,
RA   de Jong P.J., Zon L.I., Postlethwait J.H., Nusslein-Volhard C.,
RA   Hubbard T.J., Roest Crollius H., Rogers J., Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the human
RT   genome.";
RL   Nature 496:498-503(2013).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
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DR   EMBL; BX510923; CAM14038.1; -; Genomic_DNA.
DR   RefSeq; NP_001091652.1; NM_001098182.1.
DR   AlphaFoldDB; A2BGP7; -.
DR   SMR; A2BGP7; -.
DR   STRING; 7955.ENSDARP00000089271; -.
DR   PaxDb; A2BGP7; -.
DR   Ensembl; ENSDART00000098500; ENSDARP00000089271; ENSDARG00000056477.
DR   GeneID; 565477; -.
DR   KEGG; dre:565477; -.
DR   CTD; 202243; -.
DR   ZFIN; ZDB-GENE-060526-104; ccdc125.
DR   eggNOG; ENOG502QUQZ; Eukaryota.
DR   GeneTree; ENSGT00940000166823; -.
DR   InParanoid; A2BGP7; -.
DR   PhylomeDB; A2BGP7; -.
DR   TreeFam; TF332719; -.
DR   PRO; PR:A2BGP7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 5.
DR   Bgee; ENSDARG00000056477; Expressed in pharyngeal gill and 18 other tissues.
DR   ExpressionAtlas; A2BGP7; baseline and differential.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:2000146; P:negative regulation of cell motility; IBA:GO_Central.
DR   GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IBA:GO_Central.
DR   InterPro; IPR034608; CCDC125.
DR   PANTHER; PTHR28616; PTHR28616; 1.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Reference proteome.
FT   CHAIN           1..465
FT                   /note="Coiled-coil domain-containing protein 125"
FT                   /id="PRO_0000288814"
FT   REGION          65..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          432..465
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          69..208
FT                   /evidence="ECO:0000255"
FT   COILED          260..295
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        436..455
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   465 AA;  53826 MW;  7B6021DCD0C57775 CRC64;
     MGARSRRNHG HLPQMKTRGR FLDFLSHSRP IKEGGERSNG PFSWTSCRAM YSVFREELEA
     ERVARWEKRQ SESSTEDTSE ELQRRLQEVT EEVELLRTEL EVTHRHLEGK HEALRILQGQ
     AILDKATCHT KMLLQKSEER TKALEKEVNA LQWEITFNQV QFKNVENSWS LKYERVLAEN
     EALKKGLEEK MKEHQKQRTE NASLSQKCLE LLSMLSAKER RDFQRTQPSC SLRTDGSALE
     LAVYGACQCN SNGGEPCSCA RSAAASRKQV LQLKQELEQQ QKRKDEAYVM MDAFRIAFEQ
     QLRRVGENVL RQAETDRHQT HNQRHEKGKQ WSLTVGERLK KILPTTSDGR IPSDSSETLH
     MLLDLLNDKE EALAHQRKVS YMLARNTENL EKRLLMQLEE LDVSHEESKT KTVASEDYEW
     SRDCRCCADS CGSQHLSVPD DKQTYKANQP PSENRPETKP DNKDA