ZACN_CANLF
ID ZACN_CANLF Reviewed; 409 AA.
AC Q866Y9;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 111.
DE RecName: Full=Zinc-activated ligand-gated ion channel;
DE AltName: Full=Ligand-gated ion channel zinc-activated 1;
DE Flags: Precursor;
GN Name=ZACN; Synonyms=LGICZ, LGICZ1;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=12381728; DOI=10.1074/jbc.m208814200;
RA Davies P.A., Wang W., Hales T.G., Kirkness E.F.;
RT "A novel class of ligand-gated ion channel is activated by Zn2+.";
RL J. Biol. Chem. 278:712-717(2003).
CC -!- FUNCTION: Zinc-activated ligand-gated ion channel. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Multi-pass membrane
CC protein {ECO:0000250}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
CC -!- MISCELLANEOUS: The mouse and rat orthologous proteins do not exist.
CC -!- SIMILARITY: Belongs to the ligand-gated ion channel (TC 1.A.9) family.
CC {ECO:0000305}.
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DR EMBL; AF512523; AAO20972.1; -; Genomic_DNA.
DR RefSeq; NP_001010955.1; NM_001010955.1.
DR AlphaFoldDB; Q866Y9; -.
DR SMR; Q866Y9; -.
DR STRING; 9612.ENSCAFP00000007487; -.
DR PaxDb; Q866Y9; -.
DR GeneID; 483326; -.
DR KEGG; cfa:483326; -.
DR CTD; 353174; -.
DR eggNOG; KOG3645; Eukaryota.
DR HOGENOM; CLU_672608_0_0_1; -.
DR InParanoid; Q866Y9; -.
DR OMA; WATCKSD; -.
DR OrthoDB; 1001614at2759; -.
DR TreeFam; TF315605; -.
DR Proteomes; UP000002254; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0043005; C:neuron projection; IBA:GO_Central.
DR GO; GO:0045202; C:synapse; IBA:GO_Central.
DR GO; GO:0005231; F:excitatory extracellular ligand-gated ion channel activity; IBA:GO_Central.
DR GO; GO:0030594; F:neurotransmitter receptor activity; IBA:GO_Central.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:1904315; F:transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0034220; P:ion transmembrane transport; IBA:GO_Central.
DR GO; GO:0050877; P:nervous system process; IBA:GO_Central.
DR GO; GO:0042391; P:regulation of membrane potential; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 1.20.58.390; -; 1.
DR Gene3D; 2.70.170.10; -; 1.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR036719; Neuro-gated_channel_TM_sf.
DR InterPro; IPR038050; Neuro_actylchol_rec.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945; PTHR18945; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR SUPFAM; SSF63712; SSF63712; 1.
DR SUPFAM; SSF90112; SSF90112; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; Glycoprotein; Ion channel; Ion transport;
KW Ligand-gated ion channel; Membrane; Receptor; Reference proteome; Signal;
KW Transmembrane; Transmembrane helix; Transport; Zinc.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT CHAIN 19..409
FT /note="Zinc-activated ligand-gated ion channel"
FT /id="PRO_0000317164"
FT TOPO_DOM 19..233
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 234..254
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 255..265
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 266..286
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 287..296
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 297..317
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 318..365
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 366..386
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 387..409
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT REGION 325..354
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 339..354
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 55
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 157..171
FT /evidence="ECO:0000250"
SQ SEQUENCE 409 AA; 45529 MW; D62FFF76C317282E CRC64;
MAPRLLLLLL AFLRLGTTGP LVQGRGFRSP TVAWPSFFNF NQPQGVQETI QIPNNGSAPL
LVDVQVFVSN VFNVDILRYT VSSMLLLRLS WVDTRLAWNA SLYPQHAVTL PWDSLWTPGL
TIQEALWVDW QDQSPRARVG PDGHVDLYLA LTTETNCDFE LLHFPRDQSD CNLSFYALSN
TVLELEFRAH AVNEIVSVKR EYVVWGLETQ IPPRQLVPCF QVTLRLQNTA LKAIIALLVP
GEALLLADMC GGLLPLRATE RIAYKVTLLL GYLVFHSSLV QALPSSSSCN PLLIYYFTVL
LLLLFISTME TVLLAALQAR GHLSARSSPI PTPRGEQQDH GDLGPHPEEA PGVKESRSWA
EAADHIFFLV YVVGVVCSQF FFIGFWMWAT CKSDPAPGEA IPHGGQPRL
