ID   ZAM_SYNY3               Reviewed;         782 AA.
AC   Q46363; P73254;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Acetazolamide conferring resistance protein zam;
GN   Name=zam; OrderedLocusNames=sll1910;
OS   Synechocystis sp. (strain PCC 6803 / Kazusa).
OC   Bacteria; Cyanobacteria; Synechococcales; Merismopediaceae; Synechocystis;
OC   unclassified Synechocystis.
OX   NCBI_TaxID=1111708;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=7727754; DOI=10.1007/bf00020230;
RA   Beuf L., Bedu S., Cami B., Joset F.;
RT   "A protein is involved in accessibility of the inhibitor acetazolamide to
RT   the carbonic anhydrase(s) in the cyanobacterium Synechocystis PCC 6803.";
RL   Plant Mol. Biol. 27:779-788(1995).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PCC 6803 / Kazusa;
RX   PubMed=8905231; DOI=10.1093/dnares/3.3.109;
RA   Kaneko T., Sato S., Kotani H., Tanaka A., Asamizu E., Nakamura Y.,
RA   Miyajima N., Hirosawa M., Sugiura M., Sasamoto S., Kimura T., Hosouchi T.,
RA   Matsuno A., Muraki A., Nakazaki N., Naruo K., Okumura S., Shimpo S.,
RA   Takeuchi C., Wada T., Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT   "Sequence analysis of the genome of the unicellular cyanobacterium
RT   Synechocystis sp. strain PCC6803. II. Sequence determination of the entire
RT   genome and assignment of potential protein-coding regions.";
RL   DNA Res. 3:109-136(1996).
CC   -!- FUNCTION: Not known; control resistance to the carbonic anhydrase
CC       inhibitor acetazolamide.
CC   -!- SIMILARITY: Belongs to the RNR ribonuclease family. {ECO:0000305}.
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DR   EMBL; X80179; CAA56462.1; -; Genomic_DNA.
DR   EMBL; BA000022; BAA17281.1; -; Genomic_DNA.
DR   PIR; S75367; S75367.
DR   AlphaFoldDB; Q46363; -.
DR   SMR; Q46363; -.
DR   STRING; 1148.1652358; -.
DR   PaxDb; Q46363; -.
DR   EnsemblBacteria; BAA17281; BAA17281; BAA17281.
DR   KEGG; syn:sll1910; -.
DR   eggNOG; COG0557; Bacteria.
DR   InParanoid; Q46363; -.
DR   PhylomeDB; Q46363; -.
DR   Proteomes; UP000001425; Chromosome.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR   GO; GO:0004540; F:ribonuclease activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   Gene3D; 2.40.50.140; -; 2.
DR   InterPro; IPR011129; CSD.
DR   InterPro; IPR040476; CSD2.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR013223; RNase_B_OB_dom.
DR   InterPro; IPR001900; RNase_II/R.
DR   InterPro; IPR022966; RNase_II/R_CS.
DR   InterPro; IPR022967; S1_dom.
DR   InterPro; IPR003029; S1_domain.
DR   Pfam; PF17876; CSD2; 1.
DR   Pfam; PF08206; OB_RNB; 1.
DR   Pfam; PF00773; RNB; 1.
DR   Pfam; PF00575; S1; 1.
DR   SMART; SM00357; CSP; 1.
DR   SMART; SM00955; RNB; 1.
DR   SMART; SM00316; S1; 1.
DR   SUPFAM; SSF50249; SSF50249; 3.
DR   PROSITE; PS01175; RIBONUCLEASE_II; 1.
DR   PROSITE; PS50126; S1; 1.
PE   3: Inferred from homology;
KW   Exonuclease; Hydrolase; Nuclease; Reference proteome.
FT   CHAIN           1..782
FT                   /note="Acetazolamide conferring resistance protein zam"
FT                   /id="PRO_0000166417"
FT   DOMAIN          655..736
FT                   /note="S1 motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00180"
FT   REGION          737..782
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        746..782
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        59
FT                   /note="N -> K (in Ref. 2; BAA17281)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        123..124
FT                   /note="EQ -> GA (in Ref. 2; BAA17281)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        246..250
FT                   /note="TWITA -> QDYR (in Ref. 2; BAA17281)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        479
FT                   /note="G -> A (in Ref. 2; BAA17281)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        490
FT                   /note="G -> E (in Ref. 2; BAA17281)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        515
FT                   /note="G -> A (in Ref. 2; BAA17281)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        654
FT                   /note="A -> T (in Ref. 2; BAA17281)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   782 AA;  87542 MW;  5D12C0D6D50DFC78 CRC64;
     MDYSIATLLS YFVDDKLVAG KFLEKKLGCE SPEAIEALQI ALDALEKMGV LVKERGKYNR
     VTREDVVEAR LRCSSKGFCF AIQDDEDATD IYVREGNLSN AWNGDRVLVK VIKDGTRRKS
     PEEQVHLILD RANPSLLAQV KKSEDNYRAV PLDDRLLFEL ELQDKEQNLG EAVDHLVHVS
     VLRYPIAQHP PLGEVTKVLG SDAEAAADTD IVSCKHDLPL GWTPEAIEAL QSLPKVIEPG
     ELKKRTWITA KLQLVTFGDG PRGETLPWQE VALSLESQAN QWQVGIHITD IAHYIAEDSL
     LDQLARKRGT TVYLEEQICP LFPEGLIGRC SLIPDEDRLA LSFFLTVDDR GEVTGFEYHS
     SVVKVDHQLD FSEVQTALAD IESVSGELKP YGGLLQELFF QICPLIKSQR LQRGSFNLQT
     ETASPRLDEG RLGVIMTQET LPIRSLLAEL MVVLQREVAL QLQALGIPGL YCGQVAPEGE
     DLTDIVKLAG NLDLGVKIDL EGDIIPQHYH HLSQGFESLP AKAVLNHLLA NTLKIEKYFS
     HPAPHFALAY DSGYTHCVSP AQRYGDLVIQ RLLKLVLTEG RDRRTKQMKT GVELNAHTCR
     NQISWNVLPP NLQETIEGDL HQLVLGLNDR EQTAEDAEKD LLGLKKAEKM KARAGEIFRG
     LITGVQSYGF FVQIFDLLAE GLVHVSSLKD DWYEFRSRQC ALVGRKSRTS YRLGNEVDVQ
     VRSVDYYRQQ IDLGAVNNAP KDSANMDFDD DDEDGDEREE QDTMDWDAME DGDDDEGGAV
     IF