CC125_HUMAN
ID CC125_HUMAN Reviewed; 511 AA.
AC Q86Z20; Q86Z19;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Coiled-coil domain-containing protein 125;
DE AltName: Full=Protein kenae;
GN Name=CCDC125; Synonyms=KENAE;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT MET-13, FUNCTION,
RP AND SUBCELLULAR LOCATION.
RC TISSUE=Peripheral nerve;
RX PubMed=19787194; DOI=10.3892/ijmm_00000271;
RA Araya N., Arimura H., Kawahara K., Yagishita N., Ishida J., Fujii R.,
RA Aratani S., Fujita H., Sato T., Yamano Y., Higuchi I., Osame M.,
RA Nishioka K., Fukamizu A., Arimura K., Maruyama I., Nakajima T.;
RT "Role of Kenae/CCDC125 in cell motility through the deregulation of
RT RhoGTPase.";
RL Int. J. Mol. Med. 24:605-611(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15372022; DOI=10.1038/nature02919;
RA Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT "The DNA sequence and comparative analysis of human chromosome 5.";
RL Nature 431:268-274(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-504, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May be involved in the regulation of cell migration.
CC {ECO:0000269|PubMed:19787194}.
CC -!- INTERACTION:
CC Q86Z20; P18075: BMP7; NbExp=3; IntAct=EBI-11977221, EBI-1035195;
CC Q86Z20; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-11977221, EBI-8643161;
CC Q86Z20; Q0VAL7: C21orf58; NbExp=3; IntAct=EBI-11977221, EBI-10226774;
CC Q86Z20; Q8WYQ4-2: C22orf15; NbExp=3; IntAct=EBI-11977221, EBI-12030460;
CC Q86Z20; Q96LM5: C4orf45; NbExp=3; IntAct=EBI-11977221, EBI-12020542;
CC Q86Z20; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-11977221, EBI-11977221;
CC Q86Z20; P51959: CCNG1; NbExp=3; IntAct=EBI-11977221, EBI-3905829;
CC Q86Z20; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-11977221, EBI-396137;
CC Q86Z20; Q07002: CDK18; NbExp=3; IntAct=EBI-11977221, EBI-746238;
CC Q86Z20; Q96GE4: CEP95; NbExp=3; IntAct=EBI-11977221, EBI-372775;
CC Q86Z20; O15371: EIF3D; NbExp=3; IntAct=EBI-11977221, EBI-353818;
CC Q86Z20; O95990-4: FAM107A; NbExp=3; IntAct=EBI-11977221, EBI-11977223;
CC Q86Z20; Q3B820: FAM161A; NbExp=3; IntAct=EBI-11977221, EBI-719941;
CC Q86Z20; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-11977221, EBI-7225287;
CC Q86Z20; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-11977221, EBI-745689;
CC Q86Z20; Q8NA70: FAM47B; NbExp=3; IntAct=EBI-11977221, EBI-9247344;
CC Q86Z20; Q4VC44: FLYWCH1; NbExp=3; IntAct=EBI-11977221, EBI-719415;
CC Q86Z20; O95995: GAS8; NbExp=3; IntAct=EBI-11977221, EBI-1052570;
CC Q86Z20; P55040: GEM; NbExp=3; IntAct=EBI-11977221, EBI-744104;
CC Q86Z20; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-11977221, EBI-11956675;
CC Q86Z20; P56524-2: HDAC4; NbExp=3; IntAct=EBI-11977221, EBI-11953488;
CC Q86Z20; Q92993: KAT5; NbExp=3; IntAct=EBI-11977221, EBI-399080;
CC Q86Z20; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-11977221, EBI-8472129;
CC Q86Z20; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-11977221, EBI-11953846;
CC Q86Z20; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11977221, EBI-11973993;
CC Q86Z20; P12882: MYH1; NbExp=3; IntAct=EBI-11977221, EBI-366238;
CC Q86Z20; O76041: NEBL; NbExp=3; IntAct=EBI-11977221, EBI-2880203;
CC Q86Z20; Q96L73-2: NSD1; NbExp=3; IntAct=EBI-11977221, EBI-11110981;
CC Q86Z20; Q6X4W1-2: NSMF; NbExp=3; IntAct=EBI-11977221, EBI-12028784;
CC Q86Z20; Q8NHW6: OTOS; NbExp=3; IntAct=EBI-11977221, EBI-12038159;
CC Q86Z20; Q99959-2: PKP2; NbExp=3; IntAct=EBI-11977221, EBI-10987518;
CC Q86Z20; O43395: PRPF3; NbExp=3; IntAct=EBI-11977221, EBI-744322;
CC Q86Z20; Q15257-2: PTPA; NbExp=3; IntAct=EBI-11977221, EBI-12164121;
CC Q86Z20; P61019: RAB2A; NbExp=3; IntAct=EBI-11977221, EBI-752037;
CC Q86Z20; Q96MK2: RIPOR3; NbExp=3; IntAct=EBI-11977221, EBI-12010512;
CC Q86Z20; P31947: SFN; NbExp=3; IntAct=EBI-11977221, EBI-476295;
CC Q86Z20; Q13573: SNW1; NbExp=3; IntAct=EBI-11977221, EBI-632715;
CC Q86Z20; O75558: STX11; NbExp=3; IntAct=EBI-11977221, EBI-714135;
CC Q86Z20; Q9BT92: TCHP; NbExp=3; IntAct=EBI-11977221, EBI-740781;
CC Q86Z20; Q15561: TEAD4; NbExp=3; IntAct=EBI-11977221, EBI-747736;
CC Q86Z20; Q14142: TRIM14; NbExp=3; IntAct=EBI-11977221, EBI-2820256;
CC Q86Z20; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11977221, EBI-10241197;
CC Q86Z20; Q9BZF9: UACA; NbExp=3; IntAct=EBI-11977221, EBI-350510;
CC Q86Z20; P62258: YWHAE; NbExp=3; IntAct=EBI-11977221, EBI-356498;
CC Q86Z20; Q04917: YWHAH; NbExp=3; IntAct=EBI-11977221, EBI-306940;
CC Q86Z20; P27348: YWHAQ; NbExp=3; IntAct=EBI-11977221, EBI-359854;
CC Q86Z20; P63104: YWHAZ; NbExp=3; IntAct=EBI-11977221, EBI-347088;
CC Q86Z20; Q6P2D0: ZFP1; NbExp=3; IntAct=EBI-11977221, EBI-2555749;
CC Q86Z20; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-11977221, EBI-8656416;
CC Q86Z20; P49910: ZNF165; NbExp=3; IntAct=EBI-11977221, EBI-741694;
CC Q86Z20; Q9UIE0: ZNF230; NbExp=3; IntAct=EBI-11977221, EBI-1105361;
CC Q86Z20; P15622-3: ZNF250; NbExp=3; IntAct=EBI-11977221, EBI-10177272;
CC Q86Z20; P17041: ZNF32; NbExp=3; IntAct=EBI-11977221, EBI-1965483;
CC Q86Z20; Q9Y3M9: ZNF337; NbExp=3; IntAct=EBI-11977221, EBI-714987;
CC Q86Z20; Q6P1L6: ZNF343; NbExp=3; IntAct=EBI-11977221, EBI-10252492;
CC Q86Z20; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-11977221, EBI-740727;
CC Q86Z20; Q9C0F3: ZNF436; NbExp=3; IntAct=EBI-11977221, EBI-8489702;
CC Q86Z20; Q9H707: ZNF552; NbExp=3; IntAct=EBI-11977221, EBI-2555731;
CC Q86Z20; Q8N988-2: ZNF557; NbExp=3; IntAct=EBI-11977221, EBI-10699005;
CC Q86Z20; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-11977221, EBI-10273713;
CC Q86Z20; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11977221, EBI-6427977;
CC Q86Z20; Q96H86: ZNF764; NbExp=3; IntAct=EBI-11977221, EBI-745775;
CC Q86Z20; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-11977221, EBI-10240849;
CC Q86Z20; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11977221, EBI-11962574;
CC Q86Z20; P0CG24: ZNF883; NbExp=3; IntAct=EBI-11977221, EBI-18515265;
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19787194}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=Kenae-1;
CC IsoId=Q86Z20-1; Sequence=Displayed;
CC Name=2; Synonyms=Kenae-2;
CC IsoId=Q86Z20-2; Sequence=VSP_025781;
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DR EMBL; AB024691; BAC57450.1; -; mRNA.
DR EMBL; AB024692; BAC57451.1; -; mRNA.
DR EMBL; AC145132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS4000.1; -. [Q86Z20-1]
DR CCDS; CCDS75255.1; -. [Q86Z20-2]
DR RefSeq; NP_001284626.1; NM_001297697.1. [Q86Z20-2]
DR RefSeq; NP_789786.2; NM_176816.4. [Q86Z20-1]
DR RefSeq; XP_005248515.1; XM_005248458.4. [Q86Z20-1]
DR RefSeq; XP_005248520.1; XM_005248463.3. [Q86Z20-2]
DR RefSeq; XP_011541557.1; XM_011543255.2. [Q86Z20-1]
DR RefSeq; XP_011541558.1; XM_011543256.2. [Q86Z20-1]
DR AlphaFoldDB; Q86Z20; -.
DR SMR; Q86Z20; -.
DR BioGRID; 128423; 69.
DR IntAct; Q86Z20; 66.
DR STRING; 9606.ENSP00000379754; -.
DR iPTMnet; Q86Z20; -.
DR PhosphoSitePlus; Q86Z20; -.
DR BioMuta; CCDC125; -.
DR DMDM; 215273947; -.
DR jPOST; Q86Z20; -.
DR MassIVE; Q86Z20; -.
DR MaxQB; Q86Z20; -.
DR PaxDb; Q86Z20; -.
DR PeptideAtlas; Q86Z20; -.
DR PRIDE; Q86Z20; -.
DR ProteomicsDB; 70497; -. [Q86Z20-1]
DR ProteomicsDB; 70498; -. [Q86Z20-2]
DR Antibodypedia; 50133; 40 antibodies from 8 providers.
DR DNASU; 202243; -.
DR Ensembl; ENST00000396496.7; ENSP00000379754.2; ENSG00000183323.13. [Q86Z20-1]
DR Ensembl; ENST00000396499.5; ENSP00000379756.1; ENSG00000183323.13. [Q86Z20-1]
DR Ensembl; ENST00000511257.1; ENSP00000426795.1; ENSG00000183323.13. [Q86Z20-2]
DR Ensembl; ENST00000612469.4; ENSP00000484313.1; ENSG00000277868.4. [Q86Z20-2]
DR Ensembl; ENST00000619386.1; ENSP00000481190.1; ENSG00000277868.4. [Q86Z20-1]
DR Ensembl; ENST00000620431.4; ENSP00000479651.1; ENSG00000277868.4. [Q86Z20-1]
DR GeneID; 202243; -.
DR KEGG; hsa:202243; -.
DR MANE-Select; ENST00000396496.7; ENSP00000379754.2; NM_176816.5; NP_789786.2.
DR UCSC; uc003jvv.2; human. [Q86Z20-1]
DR CTD; 202243; -.
DR DisGeNET; 202243; -.
DR GeneCards; CCDC125; -.
DR HGNC; HGNC:28924; CCDC125.
DR HPA; ENSG00000183323; Low tissue specificity.
DR MIM; 613781; gene.
DR neXtProt; NX_Q86Z20; -.
DR OpenTargets; ENSG00000183323; -.
DR PharmGKB; PA147358306; -.
DR VEuPathDB; HostDB:ENSG00000183323; -.
DR eggNOG; ENOG502QUQZ; Eukaryota.
DR GeneTree; ENSGT00440000039958; -.
DR HOGENOM; CLU_035720_1_0_1; -.
DR InParanoid; Q86Z20; -.
DR OMA; MLQKTME; -.
DR OrthoDB; 1152075at2759; -.
DR PhylomeDB; Q86Z20; -.
DR TreeFam; TF332719; -.
DR PathwayCommons; Q86Z20; -.
DR SignaLink; Q86Z20; -.
DR BioGRID-ORCS; 202243; 10 hits in 1080 CRISPR screens.
DR ChiTaRS; CCDC125; human.
DR GenomeRNAi; 202243; -.
DR Pharos; Q86Z20; Tbio.
DR PRO; PR:Q86Z20; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q86Z20; protein.
DR Bgee; ENSG00000183323; Expressed in bone marrow cell and 113 other tissues.
DR ExpressionAtlas; Q86Z20; baseline and differential.
DR Genevisible; Q86Z20; HS.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR GO; GO:0090630; P:activation of GTPase activity; IDA:UniProtKB.
DR GO; GO:2000146; P:negative regulation of cell motility; IDA:UniProtKB.
DR GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IDA:UniProtKB.
DR InterPro; IPR034608; CCDC125.
DR PANTHER; PTHR28616; PTHR28616; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..511
FT /note="Coiled-coil domain-containing protein 125"
FT /id="PRO_0000288812"
FT REGION 1..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 105..243
FT /evidence="ECO:0000255"
FT COILED 293..325
FT /evidence="ECO:0000255"
FT COMPBIAS 40..54
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 76..110
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 504
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1..125
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:19787194"
FT /id="VSP_025781"
FT VARIANT 13
FT /note="V -> M (in dbSNP:rs10471774)"
FT /evidence="ECO:0000269|PubMed:19787194"
FT /id="VAR_032505"
SQ SEQUENCE 511 AA; 58629 MW; B6174A2DDA1CE2DA CRC64;
MSKVARSSSE SDVQLWETEE DDMTEGDLGY GLGRKPGGIY EIEFSHRSRK RSDGKNFSPP
PFPRKGEERN EASFQYSKHK SQQDTFPQVS RISNYRRQSS TVDSNSELSN EELRQCLNET
LEEVEMLKTE LEASQRQLRG KEEALKILQS MAILGKATSH TQAVLQKTME QNRSLEKEIN
ALQWEIEFDH NRFKNIEESW IQKYDRLNCE NAVLKENLKV KTEEIKMLKS DNAVLNQRYL
EALAMLDIKQ QKMAQENMCC DKSGFAEASG LELAVLGACL CHGPGGNPCS CARMAASTRK
LLLQLKQELE ILQKSKEEAY VMADAFRIAF EQQLMRKNDQ ALQLTQMDKM HKKATKWMNW
KHLKEDGFPS PRSKKTFGQR LLGMLPSENS SKRMEDQDSP QEVLKMLIDL LNDKEEALAH
QRKVSYMLAR ALEDKDTASN ENKEKNPIKE NFPFNNPWRK TSEFSVLGDP IHSSVCILNS
VGCICSIQHS QIDPNYRTLK RSHSLPSSII F
