位置:首页 > 蛋白库 > CC125_HUMAN
CC125_HUMAN
ID   CC125_HUMAN             Reviewed;         511 AA.
AC   Q86Z20; Q86Z19;
DT   29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   03-AUG-2022, entry version 124.
DE   RecName: Full=Coiled-coil domain-containing protein 125;
DE   AltName: Full=Protein kenae;
GN   Name=CCDC125; Synonyms=KENAE;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), VARIANT MET-13, FUNCTION,
RP   AND SUBCELLULAR LOCATION.
RC   TISSUE=Peripheral nerve;
RX   PubMed=19787194; DOI=10.3892/ijmm_00000271;
RA   Araya N., Arimura H., Kawahara K., Yagishita N., Ishida J., Fujii R.,
RA   Aratani S., Fujita H., Sato T., Yamano Y., Higuchi I., Osame M.,
RA   Nishioka K., Fukamizu A., Arimura K., Maruyama I., Nakajima T.;
RT   "Role of Kenae/CCDC125 in cell motility through the deregulation of
RT   RhoGTPase.";
RL   Int. J. Mol. Med. 24:605-611(2009).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
RN   [3]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA   Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA   Elledge S.J., Gygi S.P.;
RT   "A quantitative atlas of mitotic phosphorylation.";
RL   Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-504, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Cervix carcinoma;
RX   PubMed=23186163; DOI=10.1021/pr300630k;
RA   Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA   Mohammed S.;
RT   "Toward a comprehensive characterization of a human cancer cell
RT   phosphoproteome.";
RL   J. Proteome Res. 12:260-271(2013).
CC   -!- FUNCTION: May be involved in the regulation of cell migration.
CC       {ECO:0000269|PubMed:19787194}.
CC   -!- INTERACTION:
CC       Q86Z20; P18075: BMP7; NbExp=3; IntAct=EBI-11977221, EBI-1035195;
CC       Q86Z20; Q9NX04: C1orf109; NbExp=3; IntAct=EBI-11977221, EBI-8643161;
CC       Q86Z20; Q0VAL7: C21orf58; NbExp=3; IntAct=EBI-11977221, EBI-10226774;
CC       Q86Z20; Q8WYQ4-2: C22orf15; NbExp=3; IntAct=EBI-11977221, EBI-12030460;
CC       Q86Z20; Q96LM5: C4orf45; NbExp=3; IntAct=EBI-11977221, EBI-12020542;
CC       Q86Z20; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-11977221, EBI-11977221;
CC       Q86Z20; P51959: CCNG1; NbExp=3; IntAct=EBI-11977221, EBI-3905829;
CC       Q86Z20; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-11977221, EBI-396137;
CC       Q86Z20; Q07002: CDK18; NbExp=3; IntAct=EBI-11977221, EBI-746238;
CC       Q86Z20; Q96GE4: CEP95; NbExp=3; IntAct=EBI-11977221, EBI-372775;
CC       Q86Z20; O15371: EIF3D; NbExp=3; IntAct=EBI-11977221, EBI-353818;
CC       Q86Z20; O95990-4: FAM107A; NbExp=3; IntAct=EBI-11977221, EBI-11977223;
CC       Q86Z20; Q3B820: FAM161A; NbExp=3; IntAct=EBI-11977221, EBI-719941;
CC       Q86Z20; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-11977221, EBI-7225287;
CC       Q86Z20; Q7L5A3: FAM214B; NbExp=3; IntAct=EBI-11977221, EBI-745689;
CC       Q86Z20; Q8NA70: FAM47B; NbExp=3; IntAct=EBI-11977221, EBI-9247344;
CC       Q86Z20; Q4VC44: FLYWCH1; NbExp=3; IntAct=EBI-11977221, EBI-719415;
CC       Q86Z20; O95995: GAS8; NbExp=3; IntAct=EBI-11977221, EBI-1052570;
CC       Q86Z20; P55040: GEM; NbExp=3; IntAct=EBI-11977221, EBI-744104;
CC       Q86Z20; Q9GZV7: HAPLN2; NbExp=3; IntAct=EBI-11977221, EBI-11956675;
CC       Q86Z20; P56524-2: HDAC4; NbExp=3; IntAct=EBI-11977221, EBI-11953488;
CC       Q86Z20; Q92993: KAT5; NbExp=3; IntAct=EBI-11977221, EBI-399080;
CC       Q86Z20; Q9HAQ2: KIF9; NbExp=3; IntAct=EBI-11977221, EBI-8472129;
CC       Q86Z20; Q52LG2: KRTAP13-2; NbExp=3; IntAct=EBI-11977221, EBI-11953846;
CC       Q86Z20; Q5TA81: LCE2C; NbExp=3; IntAct=EBI-11977221, EBI-11973993;
CC       Q86Z20; P12882: MYH1; NbExp=3; IntAct=EBI-11977221, EBI-366238;
CC       Q86Z20; O76041: NEBL; NbExp=3; IntAct=EBI-11977221, EBI-2880203;
CC       Q86Z20; Q96L73-2: NSD1; NbExp=3; IntAct=EBI-11977221, EBI-11110981;
CC       Q86Z20; Q6X4W1-2: NSMF; NbExp=3; IntAct=EBI-11977221, EBI-12028784;
CC       Q86Z20; Q8NHW6: OTOS; NbExp=3; IntAct=EBI-11977221, EBI-12038159;
CC       Q86Z20; Q99959-2: PKP2; NbExp=3; IntAct=EBI-11977221, EBI-10987518;
CC       Q86Z20; O43395: PRPF3; NbExp=3; IntAct=EBI-11977221, EBI-744322;
CC       Q86Z20; Q15257-2: PTPA; NbExp=3; IntAct=EBI-11977221, EBI-12164121;
CC       Q86Z20; P61019: RAB2A; NbExp=3; IntAct=EBI-11977221, EBI-752037;
CC       Q86Z20; Q96MK2: RIPOR3; NbExp=3; IntAct=EBI-11977221, EBI-12010512;
CC       Q86Z20; P31947: SFN; NbExp=3; IntAct=EBI-11977221, EBI-476295;
CC       Q86Z20; Q13573: SNW1; NbExp=3; IntAct=EBI-11977221, EBI-632715;
CC       Q86Z20; O75558: STX11; NbExp=3; IntAct=EBI-11977221, EBI-714135;
CC       Q86Z20; Q9BT92: TCHP; NbExp=3; IntAct=EBI-11977221, EBI-740781;
CC       Q86Z20; Q15561: TEAD4; NbExp=3; IntAct=EBI-11977221, EBI-747736;
CC       Q86Z20; Q14142: TRIM14; NbExp=3; IntAct=EBI-11977221, EBI-2820256;
CC       Q86Z20; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-11977221, EBI-10241197;
CC       Q86Z20; Q9BZF9: UACA; NbExp=3; IntAct=EBI-11977221, EBI-350510;
CC       Q86Z20; P62258: YWHAE; NbExp=3; IntAct=EBI-11977221, EBI-356498;
CC       Q86Z20; Q04917: YWHAH; NbExp=3; IntAct=EBI-11977221, EBI-306940;
CC       Q86Z20; P27348: YWHAQ; NbExp=3; IntAct=EBI-11977221, EBI-359854;
CC       Q86Z20; P63104: YWHAZ; NbExp=3; IntAct=EBI-11977221, EBI-347088;
CC       Q86Z20; Q6P2D0: ZFP1; NbExp=3; IntAct=EBI-11977221, EBI-2555749;
CC       Q86Z20; Q68DK2-5: ZFYVE26; NbExp=3; IntAct=EBI-11977221, EBI-8656416;
CC       Q86Z20; P49910: ZNF165; NbExp=3; IntAct=EBI-11977221, EBI-741694;
CC       Q86Z20; Q9UIE0: ZNF230; NbExp=3; IntAct=EBI-11977221, EBI-1105361;
CC       Q86Z20; P15622-3: ZNF250; NbExp=3; IntAct=EBI-11977221, EBI-10177272;
CC       Q86Z20; P17041: ZNF32; NbExp=3; IntAct=EBI-11977221, EBI-1965483;
CC       Q86Z20; Q9Y3M9: ZNF337; NbExp=3; IntAct=EBI-11977221, EBI-714987;
CC       Q86Z20; Q6P1L6: ZNF343; NbExp=3; IntAct=EBI-11977221, EBI-10252492;
CC       Q86Z20; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-11977221, EBI-740727;
CC       Q86Z20; Q9C0F3: ZNF436; NbExp=3; IntAct=EBI-11977221, EBI-8489702;
CC       Q86Z20; Q9H707: ZNF552; NbExp=3; IntAct=EBI-11977221, EBI-2555731;
CC       Q86Z20; Q8N988-2: ZNF557; NbExp=3; IntAct=EBI-11977221, EBI-10699005;
CC       Q86Z20; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-11977221, EBI-10273713;
CC       Q86Z20; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-11977221, EBI-6427977;
CC       Q86Z20; Q96H86: ZNF764; NbExp=3; IntAct=EBI-11977221, EBI-745775;
CC       Q86Z20; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-11977221, EBI-10240849;
CC       Q86Z20; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11977221, EBI-11962574;
CC       Q86Z20; P0CG24: ZNF883; NbExp=3; IntAct=EBI-11977221, EBI-18515265;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:19787194}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1; Synonyms=Kenae-1;
CC         IsoId=Q86Z20-1; Sequence=Displayed;
CC       Name=2; Synonyms=Kenae-2;
CC         IsoId=Q86Z20-2; Sequence=VSP_025781;
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AB024691; BAC57450.1; -; mRNA.
DR   EMBL; AB024692; BAC57451.1; -; mRNA.
DR   EMBL; AC145132; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS4000.1; -. [Q86Z20-1]
DR   CCDS; CCDS75255.1; -. [Q86Z20-2]
DR   RefSeq; NP_001284626.1; NM_001297697.1. [Q86Z20-2]
DR   RefSeq; NP_789786.2; NM_176816.4. [Q86Z20-1]
DR   RefSeq; XP_005248515.1; XM_005248458.4. [Q86Z20-1]
DR   RefSeq; XP_005248520.1; XM_005248463.3. [Q86Z20-2]
DR   RefSeq; XP_011541557.1; XM_011543255.2. [Q86Z20-1]
DR   RefSeq; XP_011541558.1; XM_011543256.2. [Q86Z20-1]
DR   AlphaFoldDB; Q86Z20; -.
DR   SMR; Q86Z20; -.
DR   BioGRID; 128423; 69.
DR   IntAct; Q86Z20; 66.
DR   STRING; 9606.ENSP00000379754; -.
DR   iPTMnet; Q86Z20; -.
DR   PhosphoSitePlus; Q86Z20; -.
DR   BioMuta; CCDC125; -.
DR   DMDM; 215273947; -.
DR   jPOST; Q86Z20; -.
DR   MassIVE; Q86Z20; -.
DR   MaxQB; Q86Z20; -.
DR   PaxDb; Q86Z20; -.
DR   PeptideAtlas; Q86Z20; -.
DR   PRIDE; Q86Z20; -.
DR   ProteomicsDB; 70497; -. [Q86Z20-1]
DR   ProteomicsDB; 70498; -. [Q86Z20-2]
DR   Antibodypedia; 50133; 40 antibodies from 8 providers.
DR   DNASU; 202243; -.
DR   Ensembl; ENST00000396496.7; ENSP00000379754.2; ENSG00000183323.13. [Q86Z20-1]
DR   Ensembl; ENST00000396499.5; ENSP00000379756.1; ENSG00000183323.13. [Q86Z20-1]
DR   Ensembl; ENST00000511257.1; ENSP00000426795.1; ENSG00000183323.13. [Q86Z20-2]
DR   Ensembl; ENST00000612469.4; ENSP00000484313.1; ENSG00000277868.4. [Q86Z20-2]
DR   Ensembl; ENST00000619386.1; ENSP00000481190.1; ENSG00000277868.4. [Q86Z20-1]
DR   Ensembl; ENST00000620431.4; ENSP00000479651.1; ENSG00000277868.4. [Q86Z20-1]
DR   GeneID; 202243; -.
DR   KEGG; hsa:202243; -.
DR   MANE-Select; ENST00000396496.7; ENSP00000379754.2; NM_176816.5; NP_789786.2.
DR   UCSC; uc003jvv.2; human. [Q86Z20-1]
DR   CTD; 202243; -.
DR   DisGeNET; 202243; -.
DR   GeneCards; CCDC125; -.
DR   HGNC; HGNC:28924; CCDC125.
DR   HPA; ENSG00000183323; Low tissue specificity.
DR   MIM; 613781; gene.
DR   neXtProt; NX_Q86Z20; -.
DR   OpenTargets; ENSG00000183323; -.
DR   PharmGKB; PA147358306; -.
DR   VEuPathDB; HostDB:ENSG00000183323; -.
DR   eggNOG; ENOG502QUQZ; Eukaryota.
DR   GeneTree; ENSGT00440000039958; -.
DR   HOGENOM; CLU_035720_1_0_1; -.
DR   InParanoid; Q86Z20; -.
DR   OMA; MLQKTME; -.
DR   OrthoDB; 1152075at2759; -.
DR   PhylomeDB; Q86Z20; -.
DR   TreeFam; TF332719; -.
DR   PathwayCommons; Q86Z20; -.
DR   SignaLink; Q86Z20; -.
DR   BioGRID-ORCS; 202243; 10 hits in 1080 CRISPR screens.
DR   ChiTaRS; CCDC125; human.
DR   GenomeRNAi; 202243; -.
DR   Pharos; Q86Z20; Tbio.
DR   PRO; PR:Q86Z20; -.
DR   Proteomes; UP000005640; Chromosome 5.
DR   RNAct; Q86Z20; protein.
DR   Bgee; ENSG00000183323; Expressed in bone marrow cell and 113 other tissues.
DR   ExpressionAtlas; Q86Z20; baseline and differential.
DR   Genevisible; Q86Z20; HS.
DR   GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR   GO; GO:0042802; F:identical protein binding; IPI:IntAct.
DR   GO; GO:0090630; P:activation of GTPase activity; IDA:UniProtKB.
DR   GO; GO:2000146; P:negative regulation of cell motility; IDA:UniProtKB.
DR   GO; GO:0035024; P:negative regulation of Rho protein signal transduction; IDA:UniProtKB.
DR   InterPro; IPR034608; CCDC125.
DR   PANTHER; PTHR28616; PTHR28616; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Coiled coil; Cytoplasm; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..511
FT                   /note="Coiled-coil domain-containing protein 125"
FT                   /id="PRO_0000288812"
FT   REGION          1..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          105..243
FT                   /evidence="ECO:0000255"
FT   COILED          293..325
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        40..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        76..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         504
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:23186163"
FT   VAR_SEQ         1..125
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:19787194"
FT                   /id="VSP_025781"
FT   VARIANT         13
FT                   /note="V -> M (in dbSNP:rs10471774)"
FT                   /evidence="ECO:0000269|PubMed:19787194"
FT                   /id="VAR_032505"
SQ   SEQUENCE   511 AA;  58629 MW;  B6174A2DDA1CE2DA CRC64;
     MSKVARSSSE SDVQLWETEE DDMTEGDLGY GLGRKPGGIY EIEFSHRSRK RSDGKNFSPP
     PFPRKGEERN EASFQYSKHK SQQDTFPQVS RISNYRRQSS TVDSNSELSN EELRQCLNET
     LEEVEMLKTE LEASQRQLRG KEEALKILQS MAILGKATSH TQAVLQKTME QNRSLEKEIN
     ALQWEIEFDH NRFKNIEESW IQKYDRLNCE NAVLKENLKV KTEEIKMLKS DNAVLNQRYL
     EALAMLDIKQ QKMAQENMCC DKSGFAEASG LELAVLGACL CHGPGGNPCS CARMAASTRK
     LLLQLKQELE ILQKSKEEAY VMADAFRIAF EQQLMRKNDQ ALQLTQMDKM HKKATKWMNW
     KHLKEDGFPS PRSKKTFGQR LLGMLPSENS SKRMEDQDSP QEVLKMLIDL LNDKEEALAH
     QRKVSYMLAR ALEDKDTASN ENKEKNPIKE NFPFNNPWRK TSEFSVLGDP IHSSVCILNS
     VGCICSIQHS QIDPNYRTLK RSHSLPSSII F
 
 
维奥蛋白资源库 - 中文蛋白资源 CopyRight © 2010-2024