CC125_MOUSE
ID CC125_MOUSE Reviewed; 500 AA.
AC Q5U465; E9QPT5; Q8CEN7;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 107.
DE RecName: Full=Coiled-coil domain-containing protein 125;
GN Name=Ccdc125; Synonyms=Kenae;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Embryonic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=19787194; DOI=10.3892/ijmm_00000271;
RA Araya N., Arimura H., Kawahara K., Yagishita N., Ishida J., Fujii R.,
RA Aratani S., Fujita H., Sato T., Yamano Y., Higuchi I., Osame M.,
RA Nishioka K., Fukamizu A., Arimura K., Maruyama I., Nakajima T.;
RT "Role of Kenae/CCDC125 in cell motility through the deregulation of
RT RhoGTPase.";
RL Int. J. Mol. Med. 24:605-611(2009).
CC -!- FUNCTION: May be involved in the regulation of cell migration.
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5U465-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5U465-2; Sequence=VSP_025782, VSP_026155, VSP_025783,
CC VSP_025784;
CC -!- TISSUE SPECIFICITY: Expressed in many tissues, with highest levels in
CC spleen, thymus and bone marrow. {ECO:0000269|PubMed:19787194}.
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DR EMBL; AK017973; BAC25536.1; -; mRNA.
DR EMBL; AC165159; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC085249; AAH85249.1; -; mRNA.
DR CCDS; CCDS26736.1; -. [Q5U465-1]
DR RefSeq; NP_001161858.1; NM_001168386.2.
DR RefSeq; NP_898938.4; NM_183115.5. [Q5U465-1]
DR RefSeq; XP_011243005.1; XM_011244703.2. [Q5U465-1]
DR RefSeq; XP_011243006.1; XM_011244704.1. [Q5U465-1]
DR RefSeq; XP_011243007.1; XM_011244705.1. [Q5U465-1]
DR RefSeq; XP_017171119.1; XM_017315630.1.
DR AlphaFoldDB; Q5U465; -.
DR SMR; Q5U465; -.
DR STRING; 10090.ENSMUSP00000058484; -.
DR iPTMnet; Q5U465; -.
DR PhosphoSitePlus; Q5U465; -.
DR jPOST; Q5U465; -.
DR MaxQB; Q5U465; -.
DR PaxDb; Q5U465; -.
DR PRIDE; Q5U465; -.
DR ProteomicsDB; 281485; -. [Q5U465-1]
DR ProteomicsDB; 281486; -. [Q5U465-2]
DR Antibodypedia; 50133; 40 antibodies from 8 providers.
DR DNASU; 76041; -.
DR Ensembl; ENSMUST00000057325; ENSMUSP00000058484; ENSMUSG00000048924. [Q5U465-1]
DR GeneID; 76041; -.
DR KEGG; mmu:76041; -.
DR UCSC; uc007rrj.2; mouse. [Q5U465-1]
DR CTD; 202243; -.
DR MGI; MGI:1923291; Ccdc125.
DR VEuPathDB; HostDB:ENSMUSG00000048924; -.
DR eggNOG; ENOG502QUQZ; Eukaryota.
DR GeneTree; ENSGT00440000039958; -.
DR HOGENOM; CLU_035720_1_0_1; -.
DR InParanoid; Q5U465; -.
DR OMA; MLQKTME; -.
DR OrthoDB; 1152075at2759; -.
DR PhylomeDB; Q5U465; -.
DR TreeFam; TF332719; -.
DR BioGRID-ORCS; 76041; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Ccdc125; mouse.
DR PRO; PR:Q5U465; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q5U465; protein.
DR Bgee; ENSMUSG00000048924; Expressed in granulocyte and 81 other tissues.
DR ExpressionAtlas; Q5U465; baseline and differential.
DR Genevisible; Q5U465; MM.
DR GO; GO:0005737; C:cytoplasm; ISO:MGI.
DR GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR GO; GO:0090630; P:activation of GTPase activity; ISO:MGI.
DR GO; GO:2000146; P:negative regulation of cell motility; ISO:MGI.
DR GO; GO:0035024; P:negative regulation of Rho protein signal transduction; ISO:MGI.
DR InterPro; IPR034608; CCDC125.
DR PANTHER; PTHR28616; PTHR28616; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Cytoplasm; Phosphoprotein;
KW Reference proteome.
FT CHAIN 1..500
FT /note="Coiled-coil domain-containing protein 125"
FT /id="PRO_0000288813"
FT REGION 1..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 101..237
FT /evidence="ECO:0000255"
FT COILED 286..314
FT /evidence="ECO:0000255"
FT COMPBIAS 87..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 492
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q86Z20"
FT VAR_SEQ 1..170
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025782"
FT VAR_SEQ 171
FT /note="K -> M (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_026155"
FT VAR_SEQ 355..356
FT /note="GY -> VE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025783"
FT VAR_SEQ 357..500
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_025784"
FT CONFLICT 346
FT /note="I -> T (in Ref. 3; AAH85249)"
FT /evidence="ECO:0000305"
FT CONFLICT 468
FT /note="M -> V (in Ref. 3; AAH85249)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 500 AA; 56655 MW; 7E7E7B0AF271CEF1 CRC64;
MSKVPRSSSE AEDIWETEDD MTEGDLGYGL GRKPGGIYEV PCSITSKKRS DGKNSSPPPF
PRKGEERSET SFQYSRRKGF QDTSAEGYRA SRLSSTDSNS ELSDEQLRRR LHEALEDVEI
LKTELEASQR QLEGKEEALK ILQSMAMLGK ATSHTQTMLQ KTIEQKRSLE KEINALQWEM
EFDQDRFKNI EESWIQKCDR LNCDNAVLRE NLKLRTEEIK MLKSKNAVLN QRYLEALAML
DIKEQKMGQE ESGFTDVSGL ELAVLGACLC HGPGGSPCSC AKMAASTRKL VLQLRHELET
LQKSKEEAHI TADAFRIAFE QQLMRKNEQA LRLAGGDLCK RAATWINRQH QADDGYPAQR
RKKTLGQRLL GILPSENSSK GAEDQDNMQE VFKMLVDLLN DKEEALAHQR KVSYMLARAL
EDKDTASERN KEKIPMSQTF PFKTAWHDAS ELCGLRDPVQ SNHVSEPMAC ICSIQHPPKV
SDCPRTLKRS CSLPSTLFYK
