CC126_MOUSE
ID CC126_MOUSE Reviewed; 140 AA.
AC Q8BIS8; Q3TXH2; Q501L9;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Coiled-coil domain-containing protein 126;
DE Flags: Precursor;
GN Name=Ccdc126;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Medulla oblongata, and Osteoclast;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BIS8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BIS8-2; Sequence=VSP_025785;
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DR EMBL; AK018135; BAC25544.1; -; mRNA.
DR EMBL; AK159264; BAE34944.1; -; mRNA.
DR EMBL; BC095987; AAH95987.1; -; mRNA.
DR EMBL; BC117837; AAI17838.1; -; mRNA.
DR CCDS; CCDS20125.1; -. [Q8BIS8-1]
DR CCDS; CCDS80531.1; -. [Q8BIS8-2]
DR RefSeq; NP_001298041.1; NM_001311112.1. [Q8BIS8-2]
DR RefSeq; NP_780307.1; NM_175098.6. [Q8BIS8-1]
DR RefSeq; XP_011239722.1; XM_011241420.2. [Q8BIS8-1]
DR AlphaFoldDB; Q8BIS8; -.
DR SMR; Q8BIS8; -.
DR STRING; 10090.ENSMUSP00000058077; -.
DR GlyGen; Q8BIS8; 1 site.
DR iPTMnet; Q8BIS8; -.
DR PhosphoSitePlus; Q8BIS8; -.
DR EPD; Q8BIS8; -.
DR MaxQB; Q8BIS8; -.
DR PaxDb; Q8BIS8; -.
DR PeptideAtlas; Q8BIS8; -.
DR PRIDE; Q8BIS8; -.
DR ProteomicsDB; 279940; -. [Q8BIS8-1]
DR ProteomicsDB; 279941; -. [Q8BIS8-2]
DR Antibodypedia; 12117; 76 antibodies from 15 providers.
DR DNASU; 57895; -.
DR Ensembl; ENSMUST00000055559; ENSMUSP00000058077; ENSMUSG00000050786. [Q8BIS8-1]
DR Ensembl; ENSMUST00000114491; ENSMUSP00000110135; ENSMUSG00000050786. [Q8BIS8-2]
DR GeneID; 57895; -.
DR KEGG; mmu:57895; -.
DR UCSC; uc009bwp.1; mouse. [Q8BIS8-1]
DR UCSC; uc009bwq.1; mouse. [Q8BIS8-2]
DR CTD; 90693; -.
DR MGI; MGI:1889376; Ccdc126.
DR VEuPathDB; HostDB:ENSMUSG00000050786; -.
DR eggNOG; ENOG502RY1D; Eukaryota.
DR GeneTree; ENSGT00940000153470; -.
DR HOGENOM; CLU_136286_0_0_1; -.
DR InParanoid; Q8BIS8; -.
DR OMA; VNASAHN; -.
DR OrthoDB; 1333473at2759; -.
DR PhylomeDB; Q8BIS8; -.
DR TreeFam; TF332515; -.
DR BioGRID-ORCS; 57895; 2 hits in 72 CRISPR screens.
DR ChiTaRS; Ccdc126; mouse.
DR PRO; PR:Q8BIS8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8BIS8; protein.
DR Bgee; ENSMUSG00000050786; Expressed in pigmented layer of retina and 210 other tissues.
DR Genevisible; Q8BIS8; MM.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR InterPro; IPR042759; CCDC126.
DR InterPro; IPR027833; DUF4525.
DR PANTHER; PTHR46941; PTHR46941; 1.
DR Pfam; PF15027; DUF4525; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..35
FT /evidence="ECO:0000255"
FT CHAIN 36..140
FT /note="Coiled-coil domain-containing protein 126"
FT /id="PRO_0000288817"
FT REGION 118..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 110
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT VAR_SEQ 80..140
FT /note="ADLKRTIAVLLDDILQRLVKLESKVDYIVVNGSATNTTNGTNGNLVPVTTNK
FT RTSVSGSVR -> VLHLPGPASLYLLSNSASQEMTHC (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_025785"
SQ SEQUENCE 140 AA; 15590 MW; 8086D6DD7F44C230 CRC64;
MFRTISRKNM SQKLSFLLLV FGLIWGLMLL HYTLQQPRRQ SSVKLREQIL DLSKRYVKAL
AEESRSTADV DSGASMAGYA DLKRTIAVLL DDILQRLVKL ESKVDYIVVN GSATNTTNGT
NGNLVPVTTN KRTSVSGSVR
