CC127_HUMAN
ID CC127_HUMAN Reviewed; 260 AA.
AC Q96BQ5;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Coiled-coil domain-containing protein 127;
GN Name=CCDC127;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK098567; BAC05336.1; -; mRNA.
DR EMBL; BC015349; AAH15349.1; -; mRNA.
DR CCDS; CCDS3852.1; -.
DR RefSeq; NP_660308.1; NM_145265.2.
DR AlphaFoldDB; Q96BQ5; -.
DR SMR; Q96BQ5; -.
DR BioGRID; 126379; 21.
DR IntAct; Q96BQ5; 11.
DR MINT; Q96BQ5; -.
DR STRING; 9606.ENSP00000296824; -.
DR iPTMnet; Q96BQ5; -.
DR PhosphoSitePlus; Q96BQ5; -.
DR BioMuta; CCDC127; -.
DR DMDM; 74731264; -.
DR EPD; Q96BQ5; -.
DR jPOST; Q96BQ5; -.
DR MassIVE; Q96BQ5; -.
DR MaxQB; Q96BQ5; -.
DR PaxDb; Q96BQ5; -.
DR PeptideAtlas; Q96BQ5; -.
DR PRIDE; Q96BQ5; -.
DR ProteomicsDB; 76099; -.
DR Antibodypedia; 22206; 94 antibodies from 18 providers.
DR DNASU; 133957; -.
DR Ensembl; ENST00000296824.4; ENSP00000296824.2; ENSG00000164366.4.
DR GeneID; 133957; -.
DR KEGG; hsa:133957; -.
DR MANE-Select; ENST00000296824.4; ENSP00000296824.2; NM_145265.3; NP_660308.1.
DR UCSC; uc003jam.2; human.
DR CTD; 133957; -.
DR DisGeNET; 133957; -.
DR GeneCards; CCDC127; -.
DR HGNC; HGNC:30520; CCDC127.
DR HPA; ENSG00000164366; Low tissue specificity.
DR neXtProt; NX_Q96BQ5; -.
DR OpenTargets; ENSG00000164366; -.
DR PharmGKB; PA162381297; -.
DR VEuPathDB; HostDB:ENSG00000164366; -.
DR eggNOG; ENOG502QVKQ; Eukaryota.
DR GeneTree; ENSGT00390000008818; -.
DR HOGENOM; CLU_072814_0_0_1; -.
DR InParanoid; Q96BQ5; -.
DR OMA; KLMWLYL; -.
DR OrthoDB; 1623075at2759; -.
DR PhylomeDB; Q96BQ5; -.
DR TreeFam; TF331099; -.
DR PathwayCommons; Q96BQ5; -.
DR SignaLink; Q96BQ5; -.
DR BioGRID-ORCS; 133957; 11 hits in 1075 CRISPR screens.
DR ChiTaRS; CCDC127; human.
DR GenomeRNAi; 133957; -.
DR Pharos; Q96BQ5; Tdark.
DR PRO; PR:Q96BQ5; -.
DR Proteomes; UP000005640; Chromosome 5.
DR RNAct; Q96BQ5; protein.
DR Bgee; ENSG00000164366; Expressed in tibialis anterior and 195 other tissues.
DR ExpressionAtlas; Q96BQ5; baseline and differential.
DR Genevisible; Q96BQ5; HS.
DR InterPro; IPR034607; CCDC127.
DR PANTHER; PTHR31958; PTHR31958; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Reference proteome.
FT CHAIN 1..260
FT /note="Coiled-coil domain-containing protein 127"
FT /id="PRO_0000263750"
FT COILED 49..135
FT /evidence="ECO:0000255"
FT VARIANT 60
FT /note="R -> H (in dbSNP:rs11557427)"
FT /id="VAR_050737"
SQ SEQUENCE 260 AA; 30834 MW; 5BA395FB63A94824 CRC64;
MNNLNDPPNW NIRPNSRADG GDGSRWNYAL LVPMLGLAAF RWIWSRESQK EVEKEREAYR
RRTAAFQQDL EAKYHAMISE NRRAVAQLSL ELEKEQNRTA SYREALISQG RKLVEEKKLL
EQERAQVMQE KRQVQPLRSA YLSCLQREEN WQRRARLLLK EFEAVLTERQ NIYCSLFLPR
SKRLEIEKSL LVRASVDPVA ADLEMAAGLT DIFQHDTYCG DVWNTNKRQN GRLMWLYLKY
WELVVELKKF KRVEEAILEK
