CC127_MOUSE
ID CC127_MOUSE Reviewed; 260 AA.
AC Q3TC33; Q3TPA8; Q9CQ15;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 12-DEC-2006, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Coiled-coil domain-containing protein 127;
GN Name=Ccdc127;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J, and NOD; TISSUE=Heart, Kidney, and Pancreas;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J, and NMRI; TISSUE=Brain, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q3TC33-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q3TC33-2; Sequence=VSP_021885, VSP_021886;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK002564; BAB22190.1; -; mRNA.
DR EMBL; AK007738; BAB25225.1; -; mRNA.
DR EMBL; AK164539; BAE37829.1; -; mRNA.
DR EMBL; AK170932; BAE42124.1; -; mRNA.
DR EMBL; BC003345; AAH03345.1; -; mRNA.
DR EMBL; BC049099; AAH49099.1; -; mRNA.
DR CCDS; CCDS26644.1; -. [Q3TC33-1]
DR CCDS; CCDS49314.1; -. [Q3TC33-2]
DR RefSeq; NP_001162129.1; NM_001168658.1. [Q3TC33-2]
DR RefSeq; NP_001162130.1; NM_001168659.1. [Q3TC33-1]
DR RefSeq; NP_077163.1; NM_024201.3. [Q3TC33-1]
DR AlphaFoldDB; Q3TC33; -.
DR SMR; Q3TC33; -.
DR BioGRID; 212183; 1.
DR IntAct; Q3TC33; 2.
DR STRING; 10090.ENSMUSP00000022063; -.
DR PhosphoSitePlus; Q3TC33; -.
DR EPD; Q3TC33; -.
DR MaxQB; Q3TC33; -.
DR PaxDb; Q3TC33; -.
DR PeptideAtlas; Q3TC33; -.
DR PRIDE; Q3TC33; -.
DR ProteomicsDB; 281487; -. [Q3TC33-1]
DR ProteomicsDB; 281488; -. [Q3TC33-2]
DR Antibodypedia; 22206; 94 antibodies from 18 providers.
DR DNASU; 67433; -.
DR Ensembl; ENSMUST00000022063; ENSMUSP00000022063; ENSMUSG00000021578. [Q3TC33-1]
DR Ensembl; ENSMUST00000160021; ENSMUSP00000124193; ENSMUSG00000021578. [Q3TC33-2]
DR GeneID; 67433; -.
DR KEGG; mmu:67433; -.
DR UCSC; uc007rfb.2; mouse. [Q3TC33-1]
DR UCSC; uc007rfd.2; mouse. [Q3TC33-2]
DR CTD; 133957; -.
DR MGI; MGI:1914683; Ccdc127.
DR VEuPathDB; HostDB:ENSMUSG00000021578; -.
DR eggNOG; ENOG502QVKQ; Eukaryota.
DR GeneTree; ENSGT00390000008818; -.
DR InParanoid; Q3TC33; -.
DR OMA; KLMWLYL; -.
DR OrthoDB; 1623075at2759; -.
DR PhylomeDB; Q3TC33; -.
DR TreeFam; TF331099; -.
DR BioGRID-ORCS; 67433; 4 hits in 72 CRISPR screens.
DR ChiTaRS; Ccdc127; mouse.
DR PRO; PR:Q3TC33; -.
DR Proteomes; UP000000589; Chromosome 13.
DR RNAct; Q3TC33; protein.
DR Bgee; ENSMUSG00000021578; Expressed in interventricular septum and 243 other tissues.
DR ExpressionAtlas; Q3TC33; baseline and differential.
DR Genevisible; Q3TC33; MM.
DR InterPro; IPR034607; CCDC127.
DR PANTHER; PTHR31958; PTHR31958; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..260
FT /note="Coiled-coil domain-containing protein 127"
FT /id="PRO_0000263751"
FT COILED 76..139
FT /evidence="ECO:0000255"
FT VAR_SEQ 162..163
FT /note="VG -> ST (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021885"
FT VAR_SEQ 164..260
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_021886"
FT CONFLICT 111
FT /note="R -> H (in Ref. 1; BAE42124)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 260 AA; 30509 MW; D710ED2865D1FED0 CRC64;
MNNLNDPPNW NIRPNARADG GDGSKWNYAL LVPMLGLAAF RWIWSRESQK EIEKARKAYH
QRTAAFQQDL EAKYHAVISE HRRAVAQLSL ELEKEQNRTS SFREALISQG RKLAEEKKLL
EQERAQIKQE KSRLQPLRNV YLSCLQEEDD WQRRAQHVLK EVGEALEERQ NIYCSLIIPR
SARLELEKSL LVRTSVDPVA ADLEMAAGLS DIFKHDKHCG DVWNTNKRQN GKLMWMYLKY
WELLVELKKF KKVEKVILEK
