ID   ZAPA_PSEAE              Reviewed;         104 AA.
AC   Q9HTW3;
DT   02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 97.
DE   RecName: Full=Cell division protein ZapA;
DE   AltName: Full=Z ring-associated protein ZapA;
GN   Name=zapA; OrderedLocusNames=PA5227;
OS   Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM
OS   14847 / LMG 12228 / 1C / PRS 101 / PAO1).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Pseudomonadales;
OC   Pseudomonadaceae; Pseudomonas.
OX   NCBI_TaxID=208964;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C /
RC   PRS 101 / PAO1;
RX   PubMed=10984043; DOI=10.1038/35023079;
RA   Stover C.K., Pham X.-Q.T., Erwin A.L., Mizoguchi S.D., Warrener P.,
RA   Hickey M.J., Brinkman F.S.L., Hufnagle W.O., Kowalik D.J., Lagrou M.,
RA   Garber R.L., Goltry L., Tolentino E., Westbrock-Wadman S., Yuan Y.,
RA   Brody L.L., Coulter S.N., Folger K.R., Kas A., Larbig K., Lim R.M.,
RA   Smith K.A., Spencer D.H., Wong G.K.-S., Wu Z., Paulsen I.T., Reizer J.,
RA   Saier M.H. Jr., Hancock R.E.W., Lory S., Olson M.V.;
RT   "Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic
RT   pathogen.";
RL   Nature 406:959-964(2000).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS), AND SUBUNIT.
RX   PubMed=15288790; DOI=10.1016/j.jmb.2004.05.031;
RA   Low H.H., Moncrieffe M.C., Loewe J.;
RT   "The crystal structure of ZapA and its modulation of FtsZ polymerisation.";
RL   J. Mol. Biol. 341:839-852(2004).
RN   [3]
RP   X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS).
RG   New York structural genomix research consortium (NYSGXRC);
RT   "Structure of a conserved hypothetical protein Pseudomonas aeruginosa
RT   pa01.";
RL   Submitted (JAN-2005) to the PDB data bank.
CC   -!- FUNCTION: Activator of cell division through the inhibition of FtsZ
CC       GTPase activity, therefore promoting FtsZ assembly into bundles of
CC       protofilaments necessary for the formation of the division Z ring. It
CC       is recruited early at mid-cell but it is not essential for cell
CC       division (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Homodimer. Interacts with FtsZ (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Localizes at mid-
CC       cell. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZapA family. Type 1 subfamily.
CC       {ECO:0000305}.
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DR   EMBL; AE004091; AAG08612.1; -; Genomic_DNA.
DR   PIR; C82993; C82993.
DR   RefSeq; NP_253914.1; NC_002516.2.
DR   RefSeq; WP_003096316.1; NZ_QZGE01000002.1.
DR   PDB; 1T3U; X-ray; 2.50 A; A/B/C/D=1-104.
DR   PDB; 1W2E; X-ray; 2.80 A; A/B=1-104.
DR   PDBsum; 1T3U; -.
DR   PDBsum; 1W2E; -.
DR   AlphaFoldDB; Q9HTW3; -.
DR   SMR; Q9HTW3; -.
DR   STRING; 287.DR97_2596; -.
DR   PaxDb; Q9HTW3; -.
DR   PRIDE; Q9HTW3; -.
DR   DNASU; 878641; -.
DR   EnsemblBacteria; AAG08612; AAG08612; PA5227.
DR   GeneID; 878641; -.
DR   KEGG; pae:PA5227; -.
DR   PATRIC; fig|208964.12.peg.5477; -.
DR   PseudoCAP; PA5227; -.
DR   HOGENOM; CLU_116623_2_1_6; -.
DR   InParanoid; Q9HTW3; -.
DR   OMA; NICYELH; -.
DR   PhylomeDB; Q9HTW3; -.
DR   BioCyc; PAER208964:G1FZ6-5346-MON; -.
DR   EvolutionaryTrace; Q9HTW3; -.
DR   Proteomes; UP000002438; Chromosome.
DR   GO; GO:0032153; C:cell division site; IBA:GO_Central.
DR   GO; GO:0030428; C:cell septum; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0000917; P:division septum assembly; IBA:GO_Central.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IBA:GO_Central.
DR   GO; GO:0000921; P:septin ring assembly; IBA:GO_Central.
DR   Gene3D; 3.30.160.880; -; 1.
DR   InterPro; IPR007838; Cell_div_ZapA-like.
DR   InterPro; IPR036192; Cell_div_ZapA-like_sf.
DR   InterPro; IPR042233; Cell_div_ZapA_N.
DR   PANTHER; PTHR34981; PTHR34981; 1.
DR   Pfam; PF05164; ZapA; 1.
DR   SUPFAM; SSF102829; SSF102829; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell cycle; Cell division; Coiled coil; Cytoplasm;
KW   Reference proteome; Septation.
FT   CHAIN           1..104
FT                   /note="Cell division protein ZapA"
FT                   /id="PRO_0000345652"
FT   COILED          66..94
FT                   /evidence="ECO:0000255"
FT   STRAND          7..11
FT                   /evidence="ECO:0007829|PDB:1T3U"
FT   STRAND          14..18
FT                   /evidence="ECO:0007829|PDB:1T3U"
FT   TURN            22..24
FT                   /evidence="ECO:0007829|PDB:1T3U"
FT   HELIX           25..43
FT                   /evidence="ECO:0007829|PDB:1T3U"
FT   HELIX           51..96
FT                   /evidence="ECO:0007829|PDB:1T3U"
SQ   SEQUENCE   104 AA;  11655 MW;  CF48CE9F9F914406 CRC64;
     MSQSNTLTVQ ILDKEYCINC PDDERANLES AARYLDGKMR EIRSSGKVIG ADRVAVMAAL
     NITHDLLHRK ERLDQESSST RERVRELLDR VDRALANPAD AGEA