ID   CC134_XENTR             Reviewed;         229 AA.
AC   Q28F39; A4II25;
DT   31-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Coiled-coil domain-containing protein 134;
DE   Flags: Precursor;
GN   Name=ccdc134; ORFNames=TGas125o12.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Gastrula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: In extracellular secreted form, promotes proliferation and
CC       activation of T cells, suggesting a cytokine-like function. May inhibit
CC       ERK and JNK signaling activity and suppress cell migration and invasion
CC       activity. {ECO:0000250|UniProtKB:Q9H6E4}.
CC   -!- FUNCTION: In the nucleus, enhances activity of the PCAF histone
CC       acetyltransferase (HAT) complex. {ECO:0000250|UniProtKB:Q9H6E4}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q9H6E4}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q9H6E4}. Secreted
CC       {ECO:0000250|UniProtKB:Q9H6E4}. Endoplasmic reticulum
CC       {ECO:0000250|UniProtKB:Q9H6E4}.
CC   -!- SIMILARITY: Belongs to the CCDC134 family. {ECO:0000305}.
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DR   EMBL; CR762184; CAJ81636.1; -; mRNA.
DR   EMBL; BC135813; AAI35814.1; -; mRNA.
DR   RefSeq; NP_001016089.1; NM_001016089.3.
DR   RefSeq; XP_012816504.1; XM_012961050.2.
DR   AlphaFoldDB; Q28F39; -.
DR   STRING; 8364.ENSXETP00000023784; -.
DR   PaxDb; Q28F39; -.
DR   Ensembl; ENSXETT00000037938; ENSXETP00000037938; ENSXETG00000017448.
DR   GeneID; 548843; -.
DR   KEGG; xtr:548843; -.
DR   CTD; 79879; -.
DR   Xenbase; XB-GENE-951215; ccdc134.
DR   eggNOG; ENOG502QVE7; Eukaryota.
DR   HOGENOM; CLU_099195_0_0_1; -.
DR   InParanoid; Q28F39; -.
DR   OMA; FLENTCL; -.
DR   OrthoDB; 1509108at2759; -.
DR   PhylomeDB; Q28F39; -.
DR   TreeFam; TF323839; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000017448; Expressed in brain and 15 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:UniProtKB-SubCell.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026321; Coiled-coil_dom_con_pro_134.
DR   PANTHER; PTHR14735; PTHR14735; 1.
DR   Pfam; PF15002; ERK-JNK_inhib; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Endoplasmic reticulum; Nucleus; Reference proteome;
KW   Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6E4"
FT   CHAIN           23..229
FT                   /note="Coiled-coil domain-containing protein 134"
FT                   /id="PRO_0000254112"
FT   REGION          201..229
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          192..218
FT                   /evidence="ECO:0000255"
FT   MOTIF           206..213
FT                   /note="Nuclear localization signal"
FT                   /evidence="ECO:0000250|UniProtKB:Q9H6E4"
SQ   SEQUENCE   229 AA;  26526 MW;  EB93084B5A5E4EBF CRC64;
     MDPVQLLSFL LALLLPLGTA LDASKQKRDT AFEIYKKLFE VKRKDQINAL NNLIELNDVN
     QQYKIIDIML KGLFKVLEDS RAILIAAGVQ PDGPFPEDEK IKDAYSHTVE NSAFFGDVVL
     RFPKIVHHYF DRNSNWNNLI RWGIGFCNLS GIFDDGPHTQ LLGLMSQELG ISEKSPDYKN
     PFKMDNMEFL PNTDAFQKAL REEEKRRRKE EKRKEIRKGP RITRSRSEL