CC136_HUMAN
ID CC136_HUMAN Reviewed; 1154 AA.
AC Q96JN2; A4D1K1; A7MCY7; A8MYA7; Q6ZVK7; Q9H8M3; Q9UFE1;
DT 11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 3.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Coiled-coil domain-containing protein 136;
DE AltName: Full=Nasopharyngeal carcinoma-associated gene 6 protein;
GN Name=CCDC136; Synonyms=KIAA1793; ORFNames=NAG6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLU-1049.
RC TISSUE=Brain;
RX PubMed=11347906; DOI=10.1093/dnares/8.2.85;
RA Nagase T., Nakayama M., Nakajima D., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XX. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 8:85-95(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 410-1154 (ISOFORM 2).
RC TISSUE=Cerebellum, and Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLU-1049.
RX PubMed=12690205; DOI=10.1126/science.1083423;
RA Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K.,
RA Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R.,
RA Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A.,
RA Kanematsu E., Gentles S., Christopoulos C.C., Choufani S., Kwasnicka D.,
RA Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S.,
RA Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R.,
RA Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N.,
RA Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E.,
RA Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R.,
RA Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T.,
RA Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W.,
RA Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A.,
RA Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X.,
RA Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E.,
RA Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H.,
RA Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J.,
RA Adams M.D., Tsui L.-C.;
RT "Human chromosome 7: DNA sequence and biology.";
RL Science 300:767-772(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT GLU-1049.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLU-1049.
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 125-1154 (ISOFORM 4), AND VARIANT
RP GLU-1049.
RC TISSUE=Testis;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [8]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1128-1154 (ISOFORM 4), AND TISSUE
RP SPECIFICITY.
RC TISSUE=Nasopharyngeal carcinoma;
RX PubMed=15112360; DOI=10.3748/wjg.v10.i9.1361;
RA Zhang X.-M., Sheng S.-R., Wang X.-Y., Bin L.-H., Wang J.-R., Li G.-Y.;
RT "Expression of tumor related gene NAG6 in gastric cancer and restriction
RT fragment length polymorphism analysis.";
RL World J. Gastroenterol. 10:1361-1364(2004).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-52, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- FUNCTION: May play a role in acrosome formation in spermatogenesis and
CC in fertilization. {ECO:0000250|UniProtKB:Q3TVA9}.
CC -!- INTERACTION:
CC Q96JN2-2; Q9ULW3: ABT1; NbExp=3; IntAct=EBI-10171416, EBI-2602396;
CC Q96JN2-2; P29972: AQP1; NbExp=3; IntAct=EBI-10171416, EBI-745213;
CC Q96JN2-2; Q9H672: ASB7; NbExp=4; IntAct=EBI-10171416, EBI-3916346;
CC Q96JN2-2; P48047: ATP5PO; NbExp=3; IntAct=EBI-10171416, EBI-355815;
CC Q96JN2-2; A0AVN2: BARD1; NbExp=3; IntAct=EBI-10171416, EBI-9977322;
CC Q96JN2-2; Q9UL45: BLOC1S6; NbExp=3; IntAct=EBI-10171416, EBI-465781;
CC Q96JN2-2; Q13895: BYSL; NbExp=5; IntAct=EBI-10171416, EBI-358049;
CC Q96JN2-2; Q8TAB5: C1orf216; NbExp=3; IntAct=EBI-10171416, EBI-747505;
CC Q96JN2-2; Q9HC52: CBX8; NbExp=3; IntAct=EBI-10171416, EBI-712912;
CC Q96JN2-2; Q8IYE0-2: CCDC146; NbExp=3; IntAct=EBI-10171416, EBI-10247802;
CC Q96JN2-2; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-10171416, EBI-10175300;
CC Q96JN2-2; O14519: CDK2AP1; NbExp=3; IntAct=EBI-10171416, EBI-1052532;
CC Q96JN2-2; Q8IYX8: CEP57L1; NbExp=3; IntAct=EBI-10171416, EBI-1104570;
CC Q96JN2-2; Q8IYX8-2: CEP57L1; NbExp=3; IntAct=EBI-10171416, EBI-10181988;
CC Q96JN2-2; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-10171416, EBI-5453285;
CC Q96JN2-2; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10171416, EBI-744099;
CC Q96JN2-2; O95990-3: FAM107A; NbExp=3; IntAct=EBI-10171416, EBI-10192902;
CC Q96JN2-2; Q3B820: FAM161A; NbExp=3; IntAct=EBI-10171416, EBI-719941;
CC Q96JN2-2; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-10171416, EBI-2514791;
CC Q96JN2-2; P56524: HDAC4; NbExp=3; IntAct=EBI-10171416, EBI-308629;
CC Q96JN2-2; Q9NP66: HMG20A; NbExp=3; IntAct=EBI-10171416, EBI-740641;
CC Q96JN2-2; Q9P0W2: HMG20B; NbExp=3; IntAct=EBI-10171416, EBI-713401;
CC Q96JN2-2; Q8N9B5-2: JMY; NbExp=3; IntAct=EBI-10171416, EBI-10268138;
CC Q96JN2-2; Q7Z3B3: KANSL1; NbExp=3; IntAct=EBI-10171416, EBI-740244;
CC Q96JN2-2; Q92993: KAT5; NbExp=3; IntAct=EBI-10171416, EBI-399080;
CC Q96JN2-2; Q9BVG8: KIFC3; NbExp=3; IntAct=EBI-10171416, EBI-2125614;
CC Q96JN2-2; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-10171416, EBI-726510;
CC Q96JN2-2; O15481: MAGEB4; NbExp=3; IntAct=EBI-10171416, EBI-751857;
CC Q96JN2-2; P00540: MOS; NbExp=3; IntAct=EBI-10171416, EBI-1757866;
CC Q96JN2-2; Q96HC4: PDLIM5; NbExp=3; IntAct=EBI-10171416, EBI-751267;
CC Q96JN2-2; Q6NYC8: PPP1R18; NbExp=3; IntAct=EBI-10171416, EBI-2557469;
CC Q96JN2-2; Q8WWY3: PRPF31; NbExp=3; IntAct=EBI-10171416, EBI-1567797;
CC Q96JN2-2; O00233: PSMD9; NbExp=3; IntAct=EBI-10171416, EBI-750973;
CC Q96JN2-2; Q14088: RAB33A; NbExp=3; IntAct=EBI-10171416, EBI-744685;
CC Q96JN2-2; Q9NUL5: SHFL; NbExp=3; IntAct=EBI-10171416, EBI-10313866;
CC Q96JN2-2; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-10171416, EBI-455078;
CC Q96JN2-2; Q05BL0: TBRG1; NbExp=3; IntAct=EBI-10171416, EBI-10223693;
CC Q96JN2-2; Q15560: TCEA2; NbExp=3; IntAct=EBI-10171416, EBI-710310;
CC Q96JN2-2; P13805: TNNT1; NbExp=3; IntAct=EBI-10171416, EBI-726527;
CC Q96JN2-2; P40222: TXLNA; NbExp=5; IntAct=EBI-10171416, EBI-359793;
CC Q96JN2-2; O75604: USP2; NbExp=3; IntAct=EBI-10171416, EBI-743272;
CC Q96JN2-2; Q53FD0: ZC2HC1C; NbExp=3; IntAct=EBI-10171416, EBI-740767;
CC Q96JN2-2; P17024: ZNF20; NbExp=3; IntAct=EBI-10171416, EBI-717634;
CC Q96JN2-2; Q9UIE0: ZNF230; NbExp=3; IntAct=EBI-10171416, EBI-1105361;
CC Q96JN2-2; P15622-3: ZNF250; NbExp=3; IntAct=EBI-10171416, EBI-10177272;
CC Q96JN2-2; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-10171416, EBI-740727;
CC Q96JN2-2; Q9ULM2: ZNF490; NbExp=3; IntAct=EBI-10171416, EBI-1105370;
CC Q96JN2-2; Q8TBZ8: ZNF564; NbExp=3; IntAct=EBI-10171416, EBI-10273713;
CC Q96JN2-2; Q7Z3I7: ZNF572; NbExp=6; IntAct=EBI-10171416, EBI-10172590;
CC Q96JN2-2; Q9P0T4: ZNF581; NbExp=3; IntAct=EBI-10171416, EBI-745520;
CC Q96JN2-2; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-10171416, EBI-6427977;
CC Q96JN2-2; Q16670: ZSCAN26; NbExp=3; IntAct=EBI-10171416, EBI-3920053;
CC Q96JN2-2; Q9H6F0; NbExp=3; IntAct=EBI-10171416, EBI-10307481;
CC -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle, secretory vesicle, acrosome
CC membrane {ECO:0000250|UniProtKB:Q3TVA9}; Single-pass membrane protein
CC {ECO:0000250|UniProtKB:Q3TVA9}. Note=Exclusively localized on a
CC peripheral part of acrosome membrane (Golgi phase), localized on the
CC equatorial segment of the acrosome (maturation phase).
CC {ECO:0000250|UniProtKB:Q3TVA9}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q96JN2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96JN2-2; Sequence=VSP_027843, VSP_027844;
CC Name=3;
CC IsoId=Q96JN2-3; Sequence=VSP_027840, VSP_027841, VSP_027842;
CC Name=4;
CC IsoId=Q96JN2-4; Sequence=VSP_027845;
CC -!- TISSUE SPECIFICITY: Expressed in gastric tissues. Down-regulated in
CC gastric cancer. {ECO:0000269|PubMed:15112360}.
CC -!- MISCELLANEOUS: Restriction fragment length polymorphisms (RFLPs) in
CC gastric cancer showed loss of 5 kb fragment in comparison with the
CC corresponding normal tissue.
CC -!- SEQUENCE CAUTION:
CC Sequence=AF156971; Type=Miscellaneous discrepancy; Note=Intron retention.; Evidence={ECO:0000305};
CC Sequence=BAB14590.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAB47422.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AB058696; BAB47422.1; ALT_INIT; mRNA.
DR EMBL; AK023500; BAB14590.1; ALT_INIT; mRNA.
DR EMBL; AK124447; BAC85854.1; -; mRNA.
DR EMBL; AC024952; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC025594; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH236950; EAL24111.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83682.1; -; Genomic_DNA.
DR EMBL; CH471070; EAW83684.1; -; Genomic_DNA.
DR EMBL; BC150331; AAI50332.1; -; mRNA.
DR EMBL; BC152408; AAI52409.1; -; mRNA.
DR EMBL; AL133027; CAB61359.1; -; mRNA.
DR EMBL; AF156971; -; NOT_ANNOTATED_CDS; mRNA.
DR CCDS; CCDS47704.1; -. [Q96JN2-1]
DR CCDS; CCDS56510.1; -. [Q96JN2-3]
DR PIR; T42701; T42701.
DR RefSeq; NP_001188301.1; NM_001201372.1. [Q96JN2-3]
DR RefSeq; NP_073579.4; NM_022742.4. [Q96JN2-1]
DR RefSeq; XP_016868022.1; XM_017012533.1. [Q96JN2-4]
DR AlphaFoldDB; Q96JN2; -.
DR SMR; Q96JN2; -.
DR BioGRID; 122267; 165.
DR IntAct; Q96JN2; 81.
DR MINT; Q96JN2; -.
DR STRING; 9606.ENSP00000297788; -.
DR iPTMnet; Q96JN2; -.
DR PhosphoSitePlus; Q96JN2; -.
DR BioMuta; CCDC136; -.
DR DMDM; 296439415; -.
DR EPD; Q96JN2; -.
DR jPOST; Q96JN2; -.
DR MassIVE; Q96JN2; -.
DR MaxQB; Q96JN2; -.
DR PaxDb; Q96JN2; -.
DR PeptideAtlas; Q96JN2; -.
DR PRIDE; Q96JN2; -.
DR ProteomicsDB; 76991; -. [Q96JN2-1]
DR ProteomicsDB; 76992; -. [Q96JN2-2]
DR ProteomicsDB; 76993; -. [Q96JN2-3]
DR ProteomicsDB; 76994; -. [Q96JN2-4]
DR Antibodypedia; 2414; 41 antibodies from 10 providers.
DR DNASU; 64753; -.
DR Ensembl; ENST00000297788.9; ENSP00000297788.4; ENSG00000128596.17. [Q96JN2-1]
DR Ensembl; ENST00000378685.8; ENSP00000367956.4; ENSG00000128596.17. [Q96JN2-3]
DR GeneID; 64753; -.
DR KEGG; hsa:64753; -.
DR MANE-Select; ENST00000297788.9; ENSP00000297788.4; NM_022742.5; NP_073579.5.
DR UCSC; uc003vnu.3; human. [Q96JN2-1]
DR CTD; 64753; -.
DR DisGeNET; 64753; -.
DR GeneCards; CCDC136; -.
DR HGNC; HGNC:22225; CCDC136.
DR HPA; ENSG00000128596; Group enriched (brain, retina, testis).
DR MIM; 611902; gene.
DR neXtProt; NX_Q96JN2; -.
DR OpenTargets; ENSG00000128596; -.
DR PharmGKB; PA162381381; -.
DR VEuPathDB; HostDB:ENSG00000128596; -.
DR eggNOG; ENOG502RZUE; Eukaryota.
DR GeneTree; ENSGT00940000159122; -.
DR HOGENOM; CLU_007247_0_0_1; -.
DR InParanoid; Q96JN2; -.
DR OMA; NEKELMC; -.
DR OrthoDB; 220934at2759; -.
DR PhylomeDB; Q96JN2; -.
DR TreeFam; TF350490; -.
DR PathwayCommons; Q96JN2; -.
DR SignaLink; Q96JN2; -.
DR BioGRID-ORCS; 64753; 15 hits in 1082 CRISPR screens.
DR ChiTaRS; CCDC136; human.
DR GenomeRNAi; 64753; -.
DR Pharos; Q96JN2; Tbio.
DR PRO; PR:Q96JN2; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q96JN2; protein.
DR Bgee; ENSG00000128596; Expressed in sperm and 147 other tissues.
DR ExpressionAtlas; Q96JN2; baseline and differential.
DR Genevisible; Q96JN2; HS.
DR GO; GO:0002080; C:acrosomal membrane; ISS:UniProtKB.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0001675; P:acrosome assembly; ISS:UniProtKB.
DR GO; GO:0007338; P:single fertilization; ISS:UniProtKB.
DR GO; GO:0007283; P:spermatogenesis; ISS:UniProtKB.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasmic vesicle; Differentiation;
KW Fertilization; Membrane; Phosphoprotein; Reference proteome;
KW Spermatogenesis; Transmembrane; Transmembrane helix.
FT CHAIN 1..1154
FT /note="Coiled-coil domain-containing protein 136"
FT /id="PRO_0000300639"
FT TRANSMEM 1130..1150
FT /note="Helical"
FT /evidence="ECO:0000255"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 696..733
FT /evidence="ECO:0000255"
FT COILED 859..974
FT /evidence="ECO:0000255"
FT COMPBIAS 11..32
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1031..1071
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1072..1106
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1107..1126
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 52
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 1
FT /note="M -> MEAGAGAGAGAAGWSCPGPGPTVTTLGSYEASEGCERKKGQRWGSLE
FT RRGM (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027840"
FT VAR_SEQ 212..223
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027841"
FT VAR_SEQ 364..1121
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027842"
FT VAR_SEQ 922..957
FT /note="IKELQTKLRELQLQYQASMDEQGRLLVVQEQLEGQL -> NMFGLWKPMVFL
FT AIAAVALYVLPNMRQQESEFCLME (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027843"
FT VAR_SEQ 958..1154
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_027844"
FT VAR_SEQ 1122..1154
FT /note="SSPTPNPPIFSLPLVGLVVISALLWCWWAETSS -> NMFGLWKPMVFLAIA
FT AVALYVLPNMRQQESEFCLME (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:15112360,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_027845"
FT VARIANT 218
FT /note="D -> H (in dbSNP:rs3816887)"
FT /id="VAR_034880"
FT VARIANT 1049
FT /note="Q -> E (in dbSNP:rs4728137)"
FT /evidence="ECO:0000269|PubMed:11347906,
FT ECO:0000269|PubMed:12690205, ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005, ECO:0000269|Ref.5"
FT /id="VAR_034881"
FT CONFLICT 263..264
FT /note="QR -> HG (in Ref. 7; CAB61359)"
FT /evidence="ECO:0000305"
FT CONFLICT 490
FT /note="A -> V (in Ref. 2; BAB14590)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1154 AA; 134045 MW; FBB50829AB97E425 CRC64;
MQAMEGEVLL PALYEEEEEE EEEEEEVEEE EEQVQKGGSV GSLSVNKHRG LSLTETELEE
LRAQVLQLVA ELEETRELAG QHEDDSLELQ GLLEDERLAS AQQAEVFTKQ IQQLQGELRS
LREEISLLEH EKESELKEIE QELHLAQAEI QSLRQAAEDS ATEHESDIAS LQEDLCRMQN
ELEDMERIRG DYEMEIASLR AEMEMKSSEP SGSLGLSDYS GLQEELQELR ERYHFLNEEY
RALQESNSSL TGQLADLESE RTQRATERWL QSQTLSMTSA ESQTSEMDFL EPDPEMQLLR
QQLRDAEEQM HGMKNKCQEL CCELEELQHH RQVSEEEQRR LQRELKCAQN EVLRFQTSHS
VTQNEELKSR LCTLQKKYDT SQDEQNELLK MQLQLQTELR QLKVMKSTLV ENQSEKELLC
RLQKLHLQHQ NVTCEKEKLL ERQQQLQEEL QCHEAELQHL RDTVASFKES NEKDTETHAQ
LQEMKQLYQA SKDELERQKH MYDQLEQDLL LCQLELKELK ASHPIPEDKG KCANKCDTLL
SRLTELQEKY KASQKEMGQL QMEQCELLED QRRMQEEQGQ LQEELHRLTL PLPKSGLLLK
SQELLTKLED LCELQLLYQG MQEEQKKLIQ NQDCVLKEQL EIHEELRRFK ESHFQEVLEN
PDDSKLAKSS KCNRNKQSKL LMEQMQALQV MYDAGQAKQE LLQQEQGRLL EERKRLQADL
QLCLEEMQLL QVQSPSIKMS LESYGKSYGS MVPSNENCRK TYDTTVDDNE SYYKSYTSTQ
TSSKSFLKSY DSSTSASEAY GKSYCTTSNS SITYKKSYGS TSSSDTCQKS FVSSCTDEEP
AEPEDMERFE EMVVKVLIKL QAVQAMYQIS QEEHSQLQEQ MEKLLAKQKD LKEELDACER
EFKECMECLE KPMAPQNDKN EIKELQTKLR ELQLQYQASM DEQGRLLVVQ EQLEGQLQCC
QEELRQLREK RPSVVKEARG KNANKNMNKN ANGVKMKKVT KPCSDTSESD LETRKSLEVV
LYYKASQRKL DGLAKEEEKK EEMEEEKKQV KEEAKEQCGD ELVAEPADPE EAKSTEDQEE
NEEDKEEEEK EEDSEEEEDD ADSSLESPEE NNPLRLSESK KSSPTPNPPI FSLPLVGLVV
ISALLWCWWA ETSS
