CC137_HUMAN
ID CC137_HUMAN Reviewed; 289 AA.
AC Q6PK04;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Coiled-coil domain-containing protein 137;
GN Name=CCDC137; Synonyms=cPERP-B {ECO:0000303|PubMed:20813266};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18220336; DOI=10.1021/pr0705441;
RA Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III;
RT "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient
RT phosphoproteomic analysis.";
RL J. Proteome Res. 7:1346-1351(2008).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=18669648; DOI=10.1073/pnas.0805139105;
RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,
RA Elledge S.J., Gygi S.P.;
RT "A quantitative atlas of mitotic phosphorylation.";
RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-233, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=20813266; DOI=10.1016/j.cell.2010.07.047;
RA Ohta S., Bukowski-Wills J.C., Sanchez-Pulido L., Alves Fde L., Wood L.,
RA Chen Z.A., Platani M., Fischer L., Hudson D.F., Ponting C.P., Fukagawa T.,
RA Earnshaw W.C., Rappsilber J.;
RT "The protein composition of mitotic chromosomes determined using
RT multiclassifier combinatorial proteomics.";
RL Cell 142:810-821(2010).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [7]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [8]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT "System-wide temporal characterization of the proteome and phosphoproteome
RT of human embryonic stem cell differentiation.";
RL Sci. Signal. 4:RS3-RS3(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-19, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q6PK04; Q15554: TERF2; NbExp=2; IntAct=EBI-714654, EBI-706637;
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000269|PubMed:20813266}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; BC009369; AAH09369.1; -; mRNA.
DR CCDS; CCDS42400.1; -.
DR RefSeq; NP_954981.1; NM_199287.2.
DR AlphaFoldDB; Q6PK04; -.
DR SMR; Q6PK04; -.
DR BioGRID; 130846; 345.
DR IntAct; Q6PK04; 45.
DR MINT; Q6PK04; -.
DR STRING; 9606.ENSP00000329360; -.
DR iPTMnet; Q6PK04; -.
DR MetOSite; Q6PK04; -.
DR PhosphoSitePlus; Q6PK04; -.
DR BioMuta; CCDC137; -.
DR DMDM; 74737969; -.
DR EPD; Q6PK04; -.
DR jPOST; Q6PK04; -.
DR MassIVE; Q6PK04; -.
DR MaxQB; Q6PK04; -.
DR PaxDb; Q6PK04; -.
DR PeptideAtlas; Q6PK04; -.
DR PRIDE; Q6PK04; -.
DR ProteomicsDB; 67229; -.
DR Antibodypedia; 66426; 86 antibodies from 17 providers.
DR DNASU; 339230; -.
DR Ensembl; ENST00000329214.13; ENSP00000329360.8; ENSG00000185298.13.
DR Ensembl; ENST00000575223.5; ENSP00000458884.1; ENSG00000185298.13.
DR GeneID; 339230; -.
DR KEGG; hsa:339230; -.
DR MANE-Select; ENST00000329214.13; ENSP00000329360.8; NM_199287.3; NP_954981.1.
DR UCSC; uc002kbc.5; human.
DR CTD; 339230; -.
DR DisGeNET; 339230; -.
DR GeneCards; CCDC137; -.
DR HGNC; HGNC:33451; CCDC137.
DR HPA; ENSG00000185298; Low tissue specificity.
DR neXtProt; NX_Q6PK04; -.
DR OpenTargets; ENSG00000185298; -.
DR PharmGKB; PA162381422; -.
DR VEuPathDB; HostDB:ENSG00000185298; -.
DR eggNOG; ENOG502S2F4; Eukaryota.
DR GeneTree; ENSGT00390000004169; -.
DR InParanoid; Q6PK04; -.
DR OMA; IMKSRQE; -.
DR OrthoDB; 1191048at2759; -.
DR PhylomeDB; Q6PK04; -.
DR TreeFam; TF332311; -.
DR PathwayCommons; Q6PK04; -.
DR SignaLink; Q6PK04; -.
DR BioGRID-ORCS; 339230; 119 hits in 1081 CRISPR screens.
DR ChiTaRS; CCDC137; human.
DR GeneWiki; CCDC137; -.
DR GenomeRNAi; 339230; -.
DR Pharos; Q6PK04; Tdark.
DR PRO; PR:Q6PK04; -.
DR Proteomes; UP000005640; Chromosome 17.
DR RNAct; Q6PK04; protein.
DR Bgee; ENSG00000185298; Expressed in lower esophagus mucosa and 153 other tissues.
DR ExpressionAtlas; Q6PK04; baseline and differential.
DR Genevisible; Q6PK04; HS.
DR GO; GO:0005694; C:chromosome; IDA:UniProtKB.
DR GO; GO:0001650; C:fibrillar center; IDA:HPA.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR InterPro; IPR026680; CCDC137.
DR PANTHER; PTHR21838; PTHR21838; 1.
PE 1: Evidence at protein level;
KW Chromosome; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..289
FT /note="Coiled-coil domain-containing protein 137"
FT /id="PRO_0000288452"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 149..184
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 204..225
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 265..289
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 155..197
FT /evidence="ECO:0000255"
FT COILED 247..273
FT /evidence="ECO:0000255"
FT COMPBIAS 41..64
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 269..289
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 19
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:20068231,
FT ECO:0007744|PubMed:21406692, ECO:0007744|PubMed:23186163"
FT MOD_RES 233
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:18220336,
FT ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:19690332"
FT VARIANT 127
FT /note="H -> Q (in dbSNP:rs7226091)"
FT /id="VAR_050739"
FT VARIANT 177
FT /note="R -> W (in dbSNP:rs11150805)"
FT /id="VAR_050740"
FT VARIANT 229
FT /note="R -> Q (in dbSNP:rs11546630)"
FT /id="VAR_050741"
FT VARIANT 282
FT /note="R -> W (in dbSNP:rs11546631)"
FT /id="VAR_061582"
SQ SEQUENCE 289 AA; 33231 MW; B8C4E6EC64360771 CRC64;
MAGAGRGAAV SRVQAGPGSP RRARGRQQVQ PLGKQRPAPW PGLRSKEKKK VNCKPKNQDE
QEIPFRLREI MRSRQEMKNP ISNKKRKKAA QVTFRKTLEK EAKGEEPDIA VPKFKQRKGE
SDGAYIHRMQ QEAQHVLFLS KNQAIRQPEV QAAPKEKSEQ KKAKKAFQKR RLDKVRRKKE
EKAADRLEQE LLRDTVKFGE VVLQPPELTA RPQRSVSKDQ PGRRSQMLRM LLSPGGVSQP
LTASLARQRI VEEERERAVQ AYRALKQRQQ QLHGERPHLT SRKKPEPQL
