CC137_MOUSE
ID CC137_MOUSE Reviewed; 290 AA.
AC Q8R0K4; Q3U0P6;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Coiled-coil domain-containing protein 137;
GN Name=Ccdc137;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=NOD; TISSUE=Spleen;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Colon;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000250|UniProtKB:Q6PK04}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE33806.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK156682; BAE33806.1; ALT_SEQ; mRNA.
DR EMBL; AL669855; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC026662; AAH26662.1; -; mRNA.
DR CCDS; CCDS25736.1; -.
DR RefSeq; NP_690020.1; NM_152807.3.
DR AlphaFoldDB; Q8R0K4; -.
DR BioGRID; 212079; 1.
DR IntAct; Q8R0K4; 1.
DR MINT; Q8R0K4; -.
DR STRING; 10090.ENSMUSP00000062540; -.
DR iPTMnet; Q8R0K4; -.
DR PhosphoSitePlus; Q8R0K4; -.
DR EPD; Q8R0K4; -.
DR MaxQB; Q8R0K4; -.
DR PaxDb; Q8R0K4; -.
DR PeptideAtlas; Q8R0K4; -.
DR PRIDE; Q8R0K4; -.
DR ProteomicsDB; 265285; -.
DR Antibodypedia; 66426; 86 antibodies from 17 providers.
DR Ensembl; ENSMUST00000058370; ENSMUSP00000062540; ENSMUSG00000049957.
DR GeneID; 67291; -.
DR KEGG; mmu:67291; -.
DR UCSC; uc007msu.1; mouse.
DR CTD; 339230; -.
DR MGI; MGI:1914541; Ccdc137.
DR VEuPathDB; HostDB:ENSMUSG00000049957; -.
DR eggNOG; ENOG502S2F4; Eukaryota.
DR GeneTree; ENSGT00390000004169; -.
DR HOGENOM; CLU_079794_0_0_1; -.
DR InParanoid; Q8R0K4; -.
DR OMA; IMKSRQE; -.
DR OrthoDB; 1191048at2759; -.
DR PhylomeDB; Q8R0K4; -.
DR TreeFam; TF332311; -.
DR BioGRID-ORCS; 67291; 19 hits in 75 CRISPR screens.
DR ChiTaRS; Ccdc137; mouse.
DR PRO; PR:Q8R0K4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8R0K4; protein.
DR Bgee; ENSMUSG00000049957; Expressed in ear vesicle and 246 other tissues.
DR ExpressionAtlas; Q8R0K4; baseline and differential.
DR Genevisible; Q8R0K4; MM.
DR GO; GO:0005694; C:chromosome; ISS:UniProtKB.
DR GO; GO:0001650; C:fibrillar center; ISO:MGI.
DR GO; GO:0005730; C:nucleolus; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR InterPro; IPR026680; CCDC137.
DR PANTHER; PTHR21838; PTHR21838; 1.
PE 2: Evidence at transcript level;
KW Chromosome; Coiled coil; Reference proteome.
FT CHAIN 1..290
FT /note="Coiled-coil domain-containing protein 137"
FT /id="PRO_0000288453"
FT REGION 1..92
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..117
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 139..181
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 269..290
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 66..89
FT /evidence="ECO:0000255"
FT COILED 155..192
FT /evidence="ECO:0000255"
FT COMPBIAS 17..41
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 42..92
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 151..181
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 290 AA; 32918 MW; CA10D18955200345 CRC64;
MARPGNIALV TARSAGLRGS GQPQGRRQQQ AQGQQRSASL PGQRSKEKKK VNCKPKNQDE
QEIPFRLREI MRSRQEMKKT LSNKKRKKEA QVAFKKTLEK EAKGEEPDIA VPKFKQRKGE
SDVAYVQRME QEAQHVLFLS KNQAPRQPEV QAAPKKEKSE RKKAFQKRRL EKAQRKREAR
AVDRLEQELL KDTVKFGEVV LQPPELTVQP RRSTSRDAPG KKSLMLKKML LGPGGGSPAP
ATSLARQRIL GEERERAVQA YRALKKLHRQ EMTPAQPPGS SFQRQGHACL
