CC138_HUMAN
ID CC138_HUMAN Reviewed; 665 AA.
AC Q96M89; Q05DF1; Q4ZG07; Q53TE1; Q6ZUY5; Q86VL7;
DT 29-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Coiled-coil domain-containing protein 138;
GN Name=CCDC138;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 317-583 (ISOFORM 2).
RC TISSUE=Brain, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-48; SER-49 AND SER-469, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma, and Erythroleukemia;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
CC -!- INTERACTION:
CC Q96M89-2; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-10972887, EBI-12006120;
CC Q96M89-2; Q16543: CDC37; NbExp=3; IntAct=EBI-10972887, EBI-295634;
CC Q96M89-2; Q86XR8-3: CEP57; NbExp=3; IntAct=EBI-10972887, EBI-11752486;
CC Q96M89-2; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-10972887, EBI-7225287;
CC Q96M89-2; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-10972887, EBI-3044087;
CC Q96M89-2; Q4G0R1: PIBF1; NbExp=3; IntAct=EBI-10972887, EBI-14066006;
CC Q96M89-2; Q16512: PKN1; NbExp=3; IntAct=EBI-10972887, EBI-602382;
CC Q96M89-2; Q8N8B7-2: TCEANC; NbExp=3; IntAct=EBI-10972887, EBI-11955057;
CC Q96M89-2; Q9Y228: TRAF3IP3; NbExp=3; IntAct=EBI-10972887, EBI-765817;
CC Q96M89-2; Q9BSL1: UBAC1; NbExp=3; IntAct=EBI-10972887, EBI-749370;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96M89-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96M89-2; Sequence=VSP_025683, VSP_025684;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK057307; BAB71420.1; -; mRNA.
DR EMBL; AK125199; BAC86081.1; -; mRNA.
DR EMBL; AC010095; AAY14985.1; -; Genomic_DNA.
DR EMBL; AC073415; AAX88855.1; -; Genomic_DNA.
DR EMBL; BC015847; AAH15847.1; ALT_TERM; mRNA.
DR EMBL; BC050579; AAH50579.1; -; mRNA.
DR CCDS; CCDS2080.1; -. [Q96M89-1]
DR CCDS; CCDS77447.1; -. [Q96M89-2]
DR RefSeq; NP_001290034.1; NM_001303105.1. [Q96M89-2]
DR RefSeq; NP_659415.1; NM_144978.2. [Q96M89-1]
DR AlphaFoldDB; Q96M89; -.
DR SMR; Q96M89; -.
DR BioGRID; 127905; 119.
DR IntAct; Q96M89; 57.
DR MINT; Q96M89; -.
DR STRING; 9606.ENSP00000295124; -.
DR GlyConnect; 1123; 3 N-Linked glycans (1 site).
DR GlyGen; Q96M89; 1 site, 3 N-linked glycans (1 site).
DR iPTMnet; Q96M89; -.
DR PhosphoSitePlus; Q96M89; -.
DR BioMuta; CCDC138; -.
DR DMDM; 74732327; -.
DR EPD; Q96M89; -.
DR jPOST; Q96M89; -.
DR MassIVE; Q96M89; -.
DR MaxQB; Q96M89; -.
DR PaxDb; Q96M89; -.
DR PeptideAtlas; Q96M89; -.
DR PRIDE; Q96M89; -.
DR ProteomicsDB; 77312; -. [Q96M89-1]
DR ProteomicsDB; 77313; -. [Q96M89-2]
DR Antibodypedia; 33133; 69 antibodies from 15 providers.
DR DNASU; 165055; -.
DR Ensembl; ENST00000295124.9; ENSP00000295124.4; ENSG00000163006.12. [Q96M89-1]
DR Ensembl; ENST00000412964.6; ENSP00000411800.2; ENSG00000163006.12. [Q96M89-2]
DR GeneID; 165055; -.
DR KEGG; hsa:165055; -.
DR MANE-Select; ENST00000295124.9; ENSP00000295124.4; NM_144978.3; NP_659415.1.
DR UCSC; uc002ten.2; human. [Q96M89-1]
DR CTD; 165055; -.
DR GeneCards; CCDC138; -.
DR HGNC; HGNC:26531; CCDC138.
DR HPA; ENSG00000163006; Tissue enhanced (testis).
DR neXtProt; NX_Q96M89; -.
DR OpenTargets; ENSG00000163006; -.
DR PharmGKB; PA162381439; -.
DR VEuPathDB; HostDB:ENSG00000163006; -.
DR eggNOG; ENOG502QU8J; Eukaryota.
DR GeneTree; ENSGT00390000000217; -.
DR HOGENOM; CLU_026862_0_0_1; -.
DR InParanoid; Q96M89; -.
DR OMA; KHLNVNC; -.
DR OrthoDB; 852769at2759; -.
DR PhylomeDB; Q96M89; -.
DR TreeFam; TF329029; -.
DR PathwayCommons; Q96M89; -.
DR SignaLink; Q96M89; -.
DR BioGRID-ORCS; 165055; 7 hits in 1080 CRISPR screens.
DR ChiTaRS; CCDC138; human.
DR GenomeRNAi; 165055; -.
DR Pharos; Q96M89; Tdark.
DR PRO; PR:Q96M89; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96M89; protein.
DR Bgee; ENSG00000163006; Expressed in sperm and 110 other tissues.
DR ExpressionAtlas; Q96M89; baseline and differential.
DR Genevisible; Q96M89; HS.
DR InterPro; IPR038798; CCDC138.
DR PANTHER; PTHR34523; PTHR34523; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Phosphoprotein; Reference proteome.
FT CHAIN 1..665
FT /note="Coiled-coil domain-containing protein 138"
FT /id="PRO_0000288454"
FT COILED 198..323
FT /evidence="ECO:0000255"
FT MOD_RES 48
FT /note="Phosphothreonine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 49
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 469
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT VAR_SEQ 565..577
FT /note="KSLQPFLEACSNS -> RVIRSSLNFLRFI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_025683"
FT VAR_SEQ 578..665
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_025684"
FT VARIANT 99
FT /note="D -> Y (in dbSNP:rs35794776)"
FT /id="VAR_032420"
FT VARIANT 115
FT /note="R -> K (in dbSNP:rs6740879)"
FT /id="VAR_032421"
SQ SEQUENCE 665 AA; 76219 MW; 0723A65295914E82 CRC64;
MEPRVVKPPG QDLVVESLKS RYGLGGSCPD EYDFSNFYQS KYKRRTLTSP GDLDIYSGDK
VGSSLKYSDE SKHCRTPLGS LFKHVNVNCL DDELDSFHDL KKQETEEELI ENDYRVSTSK
ITKQSFKEIE KVALPTNTTS SRPRTECCSD AGDSPLKPVS CPKSKASDKR SLLPHQISQI
YDELFQIHLK LQCETAAQQK FAEELQKRER FLLEREQLLF RHENALSKIK GVEEEVLTRF
QIIKEQHDAE VEHLTEVLKE KNKETKRLRS SFDALKELND TLKKQLNEAS EENRKIDIQA
KRVQARLDNL QRKYEFMTIQ RLKGSSHAVH EMKSLKQEKA PVSKTYKVPL NGQVYELLTV
FMDWISDHHL SKVKHEESGM DGKKPQLKFA SQRNDIQEKC VKLLPLMTEQ LQWMPFVNIK
LHEPFVKFIY WSLRQLDAGA QHSTMTSTLR RLGEDIFKGV VTKGIQDNSP QHSVENKPKT
AAFFKSSNLP LRFLSTLIVL KTVTQADYLA QAFDSLCLDL KTEEGKTLFL EYQAVPVILS
HLRISSKGLL SNVIDSLLQM TVESKSLQPF LEACSNSLFF RTCSVLLRAP KLDLQILEKL
SIILQKLSKI KSNKKLFELF TIHLMLQEIQ RTTNPEHAFL CINLNSTLFN LGLTKCNSLV
SSASP
