CC142_HUMAN
ID CC142_HUMAN Reviewed; 750 AA.
AC Q17RM4; B7ZKV5; Q8NBJ3; Q8NBV2; Q96KA7;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 25-JUL-2006, sequence version 1.
DT 03-AUG-2022, entry version 103.
DE RecName: Full=Coiled-coil domain-containing protein 142;
GN Name=CCDC142; ORFNames=PSEC0243;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=16303743; DOI=10.1093/dnares/12.2.117;
RA Otsuki T., Ota T., Nishikawa T., Hayashi K., Suzuki Y., Yamamoto J.,
RA Wakamatsu A., Kimura K., Sakamoto K., Hatano N., Kawai Y., Ishii S.,
RA Saito K., Kojima S., Sugiyama T., Ono T., Okano K., Yoshikawa Y.,
RA Aotsuka S., Sasaki N., Hattori A., Okumura K., Nagai K., Sugano S.,
RA Isogai T.;
RT "Signal sequence and keyword trap in silico for selection of full-length
RT human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA
RT libraries.";
RL DNA Res. 12:117-126(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 100-750 (ISOFORM 3).
RC TISSUE=Placenta;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q17RM4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q17RM4-2; Sequence=VSP_029497;
CC Name=3;
CC IsoId=Q17RM4-3; Sequence=VSP_029498;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC11474.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK075543; BAC11686.1; -; mRNA.
DR EMBL; BC117269; AAI17270.1; -; mRNA.
DR EMBL; BC143398; AAI43399.1; -; mRNA.
DR EMBL; AK075209; BAC11474.1; ALT_INIT; mRNA.
DR CCDS; CCDS1945.1; -. [Q17RM4-2]
DR RefSeq; NP_116168.3; NM_032779.3. [Q17RM4-2]
DR AlphaFoldDB; Q17RM4; -.
DR BioGRID; 124310; 84.
DR STRING; 9606.ENSP00000290418; -.
DR iPTMnet; Q17RM4; -.
DR PhosphoSitePlus; Q17RM4; -.
DR BioMuta; CCDC142; -.
DR DMDM; 121940584; -.
DR MassIVE; Q17RM4; -.
DR PaxDb; Q17RM4; -.
DR PeptideAtlas; Q17RM4; -.
DR PRIDE; Q17RM4; -.
DR ProteomicsDB; 61154; -. [Q17RM4-1]
DR ProteomicsDB; 61155; -. [Q17RM4-2]
DR ProteomicsDB; 61156; -. [Q17RM4-3]
DR Antibodypedia; 68561; 17 antibodies from 9 providers.
DR DNASU; 84865; -.
DR Ensembl; ENST00000290418.4; ENSP00000290418.4; ENSG00000135637.14. [Q17RM4-2]
DR Ensembl; ENST00000393965.8; ENSP00000377537.3; ENSG00000135637.14. [Q17RM4-1]
DR GeneID; 84865; -.
DR KEGG; hsa:84865; -.
DR MANE-Select; ENST00000393965.8; ENSP00000377537.3; NM_001365575.2; NP_001352504.1.
DR UCSC; uc002slq.4; human. [Q17RM4-1]
DR CTD; 84865; -.
DR GeneCards; CCDC142; -.
DR HGNC; HGNC:25889; CCDC142.
DR HPA; ENSG00000135637; Low tissue specificity.
DR neXtProt; NX_Q17RM4; -.
DR OpenTargets; ENSG00000135637; -.
DR PharmGKB; PA162381450; -.
DR VEuPathDB; HostDB:ENSG00000135637; -.
DR eggNOG; ENOG502QUBZ; Eukaryota.
DR GeneTree; ENSGT00390000009871; -.
DR InParanoid; Q17RM4; -.
DR OMA; CQPPGPA; -.
DR OrthoDB; 489914at2759; -.
DR PhylomeDB; Q17RM4; -.
DR TreeFam; TF328445; -.
DR PathwayCommons; Q17RM4; -.
DR BioGRID-ORCS; 84865; 11 hits in 1080 CRISPR screens.
DR ChiTaRS; CCDC142; human.
DR GenomeRNAi; 84865; -.
DR Pharos; Q17RM4; Tdark.
DR PRO; PR:Q17RM4; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q17RM4; protein.
DR Bgee; ENSG00000135637; Expressed in buccal mucosa cell and 131 other tissues.
DR ExpressionAtlas; Q17RM4; baseline and differential.
DR Genevisible; Q17RM4; HS.
DR InterPro; IPR026700; CCDC142.
DR PANTHER; PTHR21436; PTHR21436; 1.
DR Pfam; PF14923; CCDC142; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..750
FT /note="Coiled-coil domain-containing protein 142"
FT /id="PRO_0000311260"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 687..714
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 87..110
FT /evidence="ECO:0000255"
FT COMPBIAS 687..709
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 420..426
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16303743"
FT /id="VSP_029497"
FT VAR_SEQ 666..750
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_029498"
FT VARIANT 534
FT /note="R -> Q (in dbSNP:rs13385919)"
FT /id="VAR_037210"
SQ SEQUENCE 750 AA; 81643 MW; 7A7C54ABB819936B CRC64;
MAQASRSGSL PPLVIVPPLR AQPGGTGEEQ WERSRTGGLR WEVHCWPSGT SGGTPWWPTP
ADVSEDYEAD AAAWRRGPAG GGPIPPALQR LRAVLLRLHR EREQLLQARD CAYHLQSAVR
LMKTLSPGSP SGGPSPLPQW CRDLQLHPSQ GAVLRIGPGE TLEPLLLARP IGLAAQCLEA
VIEMQLRALG REPASPGLSS QLAELLFALP AYHTLQRKAL SHVPGAARPF PTSRVLRLLT
GERGCQVASR LDEALQGSAL RDQLRRRCQE EGDLLPGLLG LVGGVAGSAS CGLGLGGAGA
LWSQYWTLLW AACAQSLDLN LGPWRDPRAT AQQLSQALGQ ASLPQECEKE LASLCHRLLH
QSLIWSWDQG FCQALGSALG GQSSLPTSSG TAELLQQLFP PLLDALREPR LRRIFCQPAD
PAPVALGLCT LQTTLLWFLG RAQQYLAAWD PASFLLLIQK DLPPLLHEAE ALYSLASEES
LALEVEQQLG LEIQKLTAQI QLLPEESLSV FSQECHKQAM QGFKLYMPRG RYWRLRLCPE
PPSAPSEYAG LVVRTVLEPV LQGLQGLPPQ AQAPALGQAL TAIVGAWLDH ILTHGIRFSL
QGALQLKQDF GVVRELLEEE QWSLSPDLRQ TLLMLSIFQQ LDGALLCLLQ QPLPKSQVHR
RPPCCCACQE VQTTKLPSSC LNSLESLEPP LQPGTSPAQT GQLQSTLGGR GPSPEGYLVG
NQQAWLALRQ HQRPRWHLPF FSCLGTSPES
