ID   ZAPD_ECO5E              Reviewed;         247 AA.
AC   B5YZD7;
DT   14-APR-2009, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 1.
DT   25-MAY-2022, entry version 63.
DE   RecName: Full=Cell division protein ZapD {ECO:0000255|HAMAP-Rule:MF_01092};
DE   AltName: Full=Z ring-associated protein D {ECO:0000255|HAMAP-Rule:MF_01092};
GN   Name=zapD {ECO:0000255|HAMAP-Rule:MF_01092};
GN   OrderedLocusNames=ECH74115_0109;
OS   Escherichia coli O157:H7 (strain EC4115 / EHEC).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Escherichia.
OX   NCBI_TaxID=444450;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=EC4115 / EHEC;
RX   PubMed=22135463; DOI=10.1073/pnas.1107176108;
RA   Eppinger M., Mammel M.K., Leclerc J.E., Ravel J., Cebula T.A.;
RT   "Genomic anatomy of Escherichia coli O157:H7 outbreaks.";
RL   Proc. Natl. Acad. Sci. U.S.A. 108:20142-20147(2011).
CC   -!- FUNCTION: Cell division factor that enhances FtsZ-ring assembly.
CC       Directly interacts with FtsZ and promotes bundling of FtsZ
CC       protofilaments, with a reduction in FtsZ GTPase activity.
CC       {ECO:0000255|HAMAP-Rule:MF_01092}.
CC   -!- SUBUNIT: Interacts with FtsZ. {ECO:0000255|HAMAP-Rule:MF_01092}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01092}.
CC       Note=Localizes to mid-cell in an FtsZ-dependent manner.
CC       {ECO:0000255|HAMAP-Rule:MF_01092}.
CC   -!- SIMILARITY: Belongs to the ZapD family. {ECO:0000255|HAMAP-
CC       Rule:MF_01092}.
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DR   EMBL; CP001164; ACI38181.1; -; Genomic_DNA.
DR   RefSeq; WP_001194728.1; NC_011353.1.
DR   AlphaFoldDB; B5YZD7; -.
DR   SMR; B5YZD7; -.
DR   KEGG; ecf:ECH74115_0109; -.
DR   HOGENOM; CLU_076303_0_0_6; -.
DR   OMA; LPAYYAW; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0000917; P:division septum assembly; IEA:UniProtKB-KW.
DR   GO; GO:0043093; P:FtsZ-dependent cytokinesis; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.60.440.10; -; 1.
DR   HAMAP; MF_01092; ZapD; 1.
DR   InterPro; IPR009777; ZapD.
DR   InterPro; IPR027462; ZapD_C.
DR   InterPro; IPR036268; ZapD_sf.
DR   PANTHER; PTHR39455; PTHR39455; 1.
DR   Pfam; PF07072; ZapD; 1.
DR   SUPFAM; SSF160950; SSF160950; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Septation.
FT   CHAIN           1..247
FT                   /note="Cell division protein ZapD"
FT                   /id="PRO_1000136936"
SQ   SEQUENCE   247 AA;  28308 MW;  271120D1650344BD CRC64;
     MQTQVLFEHP LNEKMRTWLR IEFLIQQLTV NLPIVDHAGA LHFFRNVSEL LDVFERGEVR
     TELLKELDRQ QRKLQTWIGV PGVDQSRIEA LIQQLKAAGS VLISAPRIGQ FLREDRLIAL
     VRQRLSIPGG CCSFDLPTLH IWLHLPQAQR DCQVETWIAS LNPLTQALTM VLDLIRQSAP
     FRKQTSLNGF YQDNGGDADL LRLNLSLDSQ LYPQISGHKS RFAIRFMPLD TENGQVPERL
     DFELACC