CC142_MOUSE
ID CC142_MOUSE Reviewed; 738 AA.
AC Q8CAI1;
DT 13-NOV-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-NOV-2007, sequence version 2.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Coiled-coil domain-containing protein 142;
GN Name=Ccdc142;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8CAI1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8CAI1-2; Sequence=VSP_029500, VSP_029501;
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK038734; BAC30114.1; -; mRNA.
DR EMBL; AC104324; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS39527.1; -. [Q8CAI1-1]
DR RefSeq; NP_001074735.1; NM_001081266.1. [Q8CAI1-1]
DR AlphaFoldDB; Q8CAI1; -.
DR iPTMnet; Q8CAI1; -.
DR PhosphoSitePlus; Q8CAI1; -.
DR PaxDb; Q8CAI1; -.
DR PRIDE; Q8CAI1; -.
DR Ensembl; ENSMUST00000101254; ENSMUSP00000098812; ENSMUSG00000107499. [Q8CAI1-1]
DR GeneID; 243510; -.
DR KEGG; mmu:243510; -.
DR UCSC; uc009cmj.1; mouse. [Q8CAI1-1]
DR CTD; 84865; -.
DR MGI; MGI:3045292; Ccdc142.
DR VEuPathDB; HostDB:ENSMUSG00000107499; -.
DR eggNOG; ENOG502QUBZ; Eukaryota.
DR GeneTree; ENSGT00390000009871; -.
DR HOGENOM; CLU_022376_0_0_1; -.
DR InParanoid; Q8CAI1; -.
DR OMA; CQPPGPA; -.
DR OrthoDB; 489914at2759; -.
DR PhylomeDB; Q8CAI1; -.
DR TreeFam; TF328445; -.
DR BioGRID-ORCS; 243510; 1 hit in 71 CRISPR screens.
DR ChiTaRS; Ccdc142; mouse.
DR PRO; PR:Q8CAI1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8CAI1; protein.
DR Bgee; ENSMUSG00000107499; Expressed in spermatocyte and 59 other tissues.
DR Genevisible; Q8CAI1; MM.
DR InterPro; IPR026700; CCDC142.
DR PANTHER; PTHR21436; PTHR21436; 1.
DR Pfam; PF14923; CCDC142; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..738
FT /note="Coiled-coil domain-containing protein 142"
FT /id="PRO_0000311261"
FT REGION 1..34
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 682..704
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 69..92
FT /evidence="ECO:0000255"
FT VAR_SEQ 319..331
FT /note="APLPQECEKELLS -> GKRGVRAGIWRLW (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029500"
FT VAR_SEQ 332..738
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_029501"
SQ SEQUENCE 738 AA; 79817 MW; CD27A6131FEC2B9C CRC64;
MARASSSSGP LPPLANVPSS WAQPVGAGEE RDEGRRGGLG LLAAVSVPCP DFSRQPWAPA
SASGPMPFAL QRLRATLLRL HREREQLLRA RDCARHLQAV VRLLRSGSSA GSLSLQQLHG
DLQLCPSRGA ALRLGFPGSR ETLLLTRPVG LAAQHLEAAI EMQLRSLGRT PASLGLTSQL
AELLLALPFY HTLQGHSLNF VPGAARPFPA ARVLQLLAAE RGCQVADKLA EARGGSGLQE
QLRRQCEQER ELLPGLLGLV GGVASTDSSG LRLGGPGALW SQYWTLLWAA CAKCLDLRVG
PWEDPRAMAQ ELSQALCQAP LPQECEKELL SLCHSLFHQS VICSWDQGFC QALGSALGGQ
SSPASLSPTS ELLQRLFPPL LDSLRQPRPE LRLCPPAGPT PVALGLCTLQ TTLLWFVGRA
QQHLAAWDPG SFLLLLQKDL PPLLSAVEAL SSLASEAALT LEVEQQLGLE IHNLTEKMQL
LPKESLGLFV QECHKQATQG FKLHMPRGRY WRLRLCPEPP SDPSEYARIV VYSVLEPVLQ
GLQGLPPEAQ APALGQALTA TLGAWLDHIL THGIRFSLQG ALQLKQDFGV VREVLEQEQW
GLSQELRQTL LSLSIFQQLD GALLCLLQQP LPKNPVHRRP PRCCLCYEVQ TTELPTSSLN
SLENLAPPLR LGVSPAQNTH LLSTLGGGGR GGGGGGGPGP SPEAYLVGNQ QAWLALRLHQ
HPRWHLPFFS CLRTSPEP
