CC146_HUMAN
ID CC146_HUMAN Reviewed; 955 AA.
AC Q8IYE0; A8K8X6; Q9P223;
DT 05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-FEB-2008, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Coiled-coil domain-containing protein 146;
GN Name=CCDC146; Synonyms=KIAA1505;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT SER-345.
RX PubMed=10819331; DOI=10.1093/dnares/7.2.143;
RA Nagase T., Kikuno R., Ishikawa K., Hirosawa M., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XVII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 7:143-150(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT GLN-263.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION.
RX PubMed=19139490; DOI=10.1074/mcp.m800504-mcp200;
RA Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B.,
RA Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L.,
RA Ying W.T., He S.M., Qian X.H.;
RT "A strategy for precise and large scale identification of core fucosylated
RT glycoproteins.";
RL Mol. Cell. Proteomics 8:913-923(2009).
RN [5]
RP SUBCELLULAR LOCATION.
RX PubMed=25074808; DOI=10.1242/jcs.157008;
RA Firat-Karalar E.N., Sante J., Elliott S., Stearns T.;
RT "Proteomic analysis of mammalian sperm cells identifies new components of
RT the centrosome.";
RL J. Cell Sci. 127:4128-4133(2014).
CC -!- INTERACTION:
CC Q8IYE0; Q6PJH3: AKAP9; NbExp=3; IntAct=EBI-10749669, EBI-11745576;
CC Q8IYE0; Q6QNY1: BLOC1S2; NbExp=3; IntAct=EBI-10749669, EBI-465872;
CC Q8IYE0; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-10749669, EBI-11524851;
CC Q8IYE0; Q8NCU1: CCDC197; NbExp=5; IntAct=EBI-10749669, EBI-750686;
CC Q8IYE0; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10749669, EBI-748961;
CC Q8IYE0; Q01850: CDR2; NbExp=3; IntAct=EBI-10749669, EBI-1181367;
CC Q8IYE0; Q86X02: CDR2L; NbExp=3; IntAct=EBI-10749669, EBI-11063830;
CC Q8IYE0; Q9H3R5: CENPH; NbExp=3; IntAct=EBI-10749669, EBI-1003700;
CC Q8IYE0; Q9C0F1: CEP44; NbExp=3; IntAct=EBI-10749669, EBI-744115;
CC Q8IYE0; A1L4K1: FSD2; NbExp=3; IntAct=EBI-10749669, EBI-5661036;
CC Q8IYE0; O95995: GAS8; NbExp=3; IntAct=EBI-10749669, EBI-1052570;
CC Q8IYE0; O75496: GMNN; NbExp=4; IntAct=EBI-10749669, EBI-371669;
CC Q8IYE0; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10749669, EBI-5916454;
CC Q8IYE0; Q96D09: GPRASP2; NbExp=3; IntAct=EBI-10749669, EBI-473189;
CC Q8IYE0; Q6IC98: GRAMD4; NbExp=3; IntAct=EBI-10749669, EBI-10962409;
CC Q8IYE0; O75031: HSF2BP; NbExp=3; IntAct=EBI-10749669, EBI-7116203;
CC Q8IYE0; Q2T9L4: INSYN1; NbExp=3; IntAct=EBI-10749669, EBI-4311436;
CC Q8IYE0; Q9BVG8-5: KIFC3; NbExp=3; IntAct=EBI-10749669, EBI-14069005;
CC Q8IYE0; P08779: KRT16; NbExp=3; IntAct=EBI-10749669, EBI-356410;
CC Q8IYE0; Q2M2I5: KRT24; NbExp=3; IntAct=EBI-10749669, EBI-2952736;
CC Q8IYE0; Q7Z3Y9: KRT26; NbExp=3; IntAct=EBI-10749669, EBI-12084444;
CC Q8IYE0; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-10749669, EBI-3044087;
CC Q8IYE0; Q15323: KRT31; NbExp=3; IntAct=EBI-10749669, EBI-948001;
CC Q8IYE0; O76011: KRT34; NbExp=3; IntAct=EBI-10749669, EBI-1047093;
CC Q8IYE0; O76015: KRT38; NbExp=5; IntAct=EBI-10749669, EBI-1047263;
CC Q8IYE0; O43790: KRT86; NbExp=3; IntAct=EBI-10749669, EBI-9996498;
CC Q8IYE0; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-10749669, EBI-12039345;
CC Q8IYE0; P43364: MAGEA11; NbExp=3; IntAct=EBI-10749669, EBI-739552;
CC Q8IYE0; P43360: MAGEA6; NbExp=3; IntAct=EBI-10749669, EBI-1045155;
CC Q8IYE0; P23508: MCC; NbExp=3; IntAct=EBI-10749669, EBI-307531;
CC Q8IYE0; Q8TD10: MIPOL1; NbExp=3; IntAct=EBI-10749669, EBI-2548751;
CC Q8IYE0; Q9Y605: MRFAP1; NbExp=3; IntAct=EBI-10749669, EBI-995714;
CC Q8IYE0; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-10749669, EBI-11522433;
CC Q8IYE0; O15049: N4BP3; NbExp=5; IntAct=EBI-10749669, EBI-2512055;
CC Q8IYE0; Q9ULW6: NAP1L2; NbExp=3; IntAct=EBI-10749669, EBI-3911716;
CC Q8IYE0; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-10749669, EBI-10172876;
CC Q8IYE0; P37198: NUP62; NbExp=5; IntAct=EBI-10749669, EBI-347978;
CC Q8IYE0; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-10749669, EBI-9640281;
CC Q8IYE0; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-10749669, EBI-742388;
CC Q8IYE0; Q969Q6: PPP2R3C; NbExp=3; IntAct=EBI-10749669, EBI-2561661;
CC Q8IYE0; Q2NL68: PROSER3; NbExp=3; IntAct=EBI-10749669, EBI-11336487;
CC Q8IYE0; Q9Y3L3: SH3BP1; NbExp=3; IntAct=EBI-10749669, EBI-346869;
CC Q8IYE0; Q96N21: TEPSIN; NbExp=3; IntAct=EBI-10749669, EBI-11139477;
CC Q8IYE0; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-10749669, EBI-1105213;
CC Q8IYE0; Q6I9Y2: THOC7; NbExp=3; IntAct=EBI-10749669, EBI-716286;
CC Q8IYE0; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-10749669, EBI-2130429;
CC Q8IYE0; Q8N7C3: TRIML2; NbExp=3; IntAct=EBI-10749669, EBI-11059915;
CC Q8IYE0; P40222: TXLNA; NbExp=3; IntAct=EBI-10749669, EBI-359793;
CC Q8IYE0; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-10749669, EBI-739895;
CC Q8IYE0; Q9UK41-2: VPS28; NbExp=3; IntAct=EBI-10749669, EBI-12146727;
CC Q8IYE0; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-10749669, EBI-2799833;
CC Q8IYE0-2; Q8NA61: CBY2; NbExp=3; IntAct=EBI-10247802, EBI-741724;
CC Q8IYE0-2; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-10247802, EBI-10171416;
CC Q8IYE0-2; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10247802, EBI-748961;
CC Q8IYE0-2; Q96L14: CEP170P1; NbExp=3; IntAct=EBI-10247802, EBI-743488;
CC Q8IYE0-2; Q9C0F1: CEP44; NbExp=3; IntAct=EBI-10247802, EBI-744115;
CC Q8IYE0-2; Q96EV8: DTNBP1; NbExp=3; IntAct=EBI-10247802, EBI-465804;
CC Q8IYE0-2; O75496: GMNN; NbExp=4; IntAct=EBI-10247802, EBI-371669;
CC Q8IYE0-2; Q08379: GOLGA2; NbExp=3; IntAct=EBI-10247802, EBI-618309;
CC Q8IYE0-2; P05783: KRT18; NbExp=3; IntAct=EBI-10247802, EBI-297888;
CC Q8IYE0-2; P08727: KRT19; NbExp=3; IntAct=EBI-10247802, EBI-742756;
CC Q8IYE0-2; O76015: KRT38; NbExp=4; IntAct=EBI-10247802, EBI-1047263;
CC Q8IYE0-2; Q6A162: KRT40; NbExp=3; IntAct=EBI-10247802, EBI-10171697;
CC Q8IYE0-2; P43364-2: MAGEA11; NbExp=3; IntAct=EBI-10247802, EBI-10178634;
CC Q8IYE0-2; P43360: MAGEA6; NbExp=3; IntAct=EBI-10247802, EBI-1045155;
CC Q8IYE0-2; Q9NPJ6: MED4; NbExp=3; IntAct=EBI-10247802, EBI-394607;
CC Q8IYE0-2; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-10247802, EBI-742948;
CC Q8IYE0-2; Q7Z6G3-2: NECAB2; NbExp=3; IntAct=EBI-10247802, EBI-10172876;
CC Q8IYE0-2; Q9Y2I6: NINL; NbExp=3; IntAct=EBI-10247802, EBI-719716;
CC Q8IYE0-2; P37198: NUP62; NbExp=3; IntAct=EBI-10247802, EBI-347978;
CC Q8IYE0-2; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-10247802, EBI-302345;
CC Q8IYE0-2; P62333: PSMC6; NbExp=3; IntAct=EBI-10247802, EBI-357669;
CC Q8IYE0-2; Q6NUQ1: RINT1; NbExp=3; IntAct=EBI-10247802, EBI-726876;
CC Q8IYE0-2; O75150: RNF40; NbExp=3; IntAct=EBI-10247802, EBI-744408;
CC Q8IYE0-2; Q96KN7: RPGRIP1; NbExp=3; IntAct=EBI-10247802, EBI-1050213;
CC Q8IYE0-2; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-10247802, EBI-1105213;
CC Q8IYE0-2; A1L306: TNR; NbExp=3; IntAct=EBI-10247802, EBI-10182881;
CC Q8IYE0-2; Q5VU62: TPM3; NbExp=3; IntAct=EBI-10247802, EBI-10184033;
CC Q8IYE0-2; Q13077: TRAF1; NbExp=3; IntAct=EBI-10247802, EBI-359224;
CC Q8IYE0-2; P36406: TRIM23; NbExp=3; IntAct=EBI-10247802, EBI-740098;
CC Q8IYE0-2; Q9BYV2: TRIM54; NbExp=3; IntAct=EBI-10247802, EBI-2130429;
CC Q8IYE0-2; Q9Y3Q8: TSC22D4; NbExp=3; IntAct=EBI-10247802, EBI-739485;
CC Q8IYE0-2; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-10247802, EBI-739895;
CC Q8IYE0-2; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-10247802, EBI-2799833;
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC center, centrosome, centriole {ECO:0000269|PubMed:25074808}.
CC Note=Localized to only one centriole identified as the mother centriole
CC by co-staining with CEP164. {ECO:0000269|PubMed:25074808}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IYE0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IYE0-2; Sequence=VSP_030926, VSP_030927;
CC -!- CAUTION: A report observed N-glycosylation at Asn-815
CC (PubMed:19139490). However, as the protein is not predicted to localize
CC in an extracellular compartment of the cell, additional evidence is
CC required to confirm this result. {ECO:0000305|PubMed:19139490}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA96029.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB040938; BAA96029.1; ALT_INIT; mRNA.
DR EMBL; AK292491; BAF85180.1; -; mRNA.
DR EMBL; BC036053; AAH36053.1; -; mRNA.
DR CCDS; CCDS34671.1; -. [Q8IYE0-1]
DR RefSeq; NP_065930.2; NM_020879.2. [Q8IYE0-1]
DR AlphaFoldDB; Q8IYE0; -.
DR SMR; Q8IYE0; -.
DR BioGRID; 121678; 77.
DR IntAct; Q8IYE0; 76.
DR STRING; 9606.ENSP00000285871; -.
DR CarbonylDB; Q8IYE0; -.
DR iPTMnet; Q8IYE0; -.
DR PhosphoSitePlus; Q8IYE0; -.
DR BioMuta; CCDC146; -.
DR DMDM; 167006541; -.
DR EPD; Q8IYE0; -.
DR jPOST; Q8IYE0; -.
DR MassIVE; Q8IYE0; -.
DR PaxDb; Q8IYE0; -.
DR PeptideAtlas; Q8IYE0; -.
DR PRIDE; Q8IYE0; -.
DR ProteomicsDB; 71162; -. [Q8IYE0-1]
DR ProteomicsDB; 71163; -. [Q8IYE0-2]
DR Antibodypedia; 15014; 93 antibodies from 18 providers.
DR DNASU; 57639; -.
DR Ensembl; ENST00000285871.5; ENSP00000285871.4; ENSG00000135205.15. [Q8IYE0-1]
DR GeneID; 57639; -.
DR KEGG; hsa:57639; -.
DR MANE-Select; ENST00000285871.5; ENSP00000285871.4; NM_020879.3; NP_065930.2.
DR UCSC; uc003uga.3; human. [Q8IYE0-1]
DR CTD; 57639; -.
DR DisGeNET; 57639; -.
DR GeneCards; CCDC146; -.
DR HGNC; HGNC:29296; CCDC146.
DR HPA; ENSG00000135205; Tissue enhanced (fallopian).
DR MIM; 619829; gene.
DR neXtProt; NX_Q8IYE0; -.
DR OpenTargets; ENSG00000135205; -.
DR PharmGKB; PA162381475; -.
DR VEuPathDB; HostDB:ENSG00000135205; -.
DR eggNOG; ENOG502QPM4; Eukaryota.
DR GeneTree; ENSGT00530000063534; -.
DR HOGENOM; CLU_012766_1_0_1; -.
DR InParanoid; Q8IYE0; -.
DR OMA; QCTDRIR; -.
DR PhylomeDB; Q8IYE0; -.
DR TreeFam; TF328680; -.
DR PathwayCommons; Q8IYE0; -.
DR SignaLink; Q8IYE0; -.
DR BioGRID-ORCS; 57639; 9 hits in 1073 CRISPR screens.
DR ChiTaRS; CCDC146; human.
DR GenomeRNAi; 57639; -.
DR Pharos; Q8IYE0; Tdark.
DR PRO; PR:Q8IYE0; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8IYE0; protein.
DR Bgee; ENSG00000135205; Expressed in right uterine tube and 153 other tissues.
DR ExpressionAtlas; Q8IYE0; baseline and differential.
DR Genevisible; Q8IYE0; HS.
DR GO; GO:0005814; C:centriole; IDA:UniProtKB.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Cytoplasm; Cytoskeleton;
KW Reference proteome.
FT CHAIN 1..955
FT /note="Coiled-coil domain-containing protein 146"
FT /id="PRO_0000317252"
FT REGION 1..22
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 114..141
FT /evidence="ECO:0000255"
FT COILED 169..321
FT /evidence="ECO:0000255"
FT COILED 400..461
FT /evidence="ECO:0000255"
FT COILED 534..640
FT /evidence="ECO:0000255"
FT COILED 667..832
FT /evidence="ECO:0000255"
FT COMPBIAS 1..19
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..254
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10819331"
FT /id="VSP_030926"
FT VAR_SEQ 392..423
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10819331"
FT /id="VSP_030927"
FT VARIANT 263
FT /note="E -> Q (in dbSNP:rs17853516)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_061583"
FT VARIANT 345
FT /note="N -> S (in dbSNP:rs1109968)"
FT /evidence="ECO:0000269|PubMed:10819331"
FT /id="VAR_050742"
FT VARIANT 466
FT /note="I -> T (in dbSNP:rs58545343)"
FT /id="VAR_061584"
FT CONFLICT 655
FT /note="Y -> H (in Ref. 2; BAF85180)"
FT /evidence="ECO:0000305"
FT CONFLICT 829
FT /note="M -> I (in Ref. 2; BAF85180)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 955 AA; 112806 MW; B434DD95EF1019FF CRC64;
MEDSSTDTEK EEEEEKDEKD QEPIYAIVPT INIQDERFVD LSETPAFIFL HELHAMGKLP
GTRMAALKAK YTLLHDAVMS TQESEVQLLQ NAKRFTEQIQ QQQFHLQQAD NFPEAFSTEV
SKMREQLLKY QNEYNAVKER EFHNQYRLNS LKEEKIIIVK EFEKITKPGE MEKKMKILRE
STEELRKEIM QKKLEIKNLR EDLASKQKQL LKEQKELEEL LGHQVVLKDE VAHHQTIPVQ
IGKEIEKITR KKVEMEKKKI VLEQEVKTLN DSLKKVENKV SAIVDEKENV IKEVEGKRAL
LEIKEREHNQ LVKLLELARE NEATSLTERG ILDLNLRNSL IDKQNYHDEL SRKQREKERD
FRNLRKMELL LKVSWDALRQ TQALHQRLLL EMEAIPKDDS TLSERRRELH KEVEVAKRNL
AQQKIISEME SKLVEQQLAE ENKLLKEQEN MKELVVNLLR MTQIKIDEKE QKSKDFLKAQ
QKYTNIVKEM KAKDLEIRIH KKKKCEIYRR LREFAKLYDT IRNERNKFVN LLHKAHQKVN
EIKERHKMSL NELEILRNSA VSQERKLQNS MLKHANNVTI RESMQNDVRK IVSKLQEMKE
KKEAQLNNID RLANTITMIE EEMVQLRKRY EKAVQHRNES GVQLIEREEE ICIFYEKINI
QEKMKLNGEI EIHLLEEKIQ FLKMKIAEKQ RQICVTQKLL PAKRSLDADL AVLQIQFSQC
TDRIKDLEKQ FVKPDGENRA RFLPGKDLTE KEMIQKLDKL ELQLAKKEEK LLEKDFIYEQ
VSRLTDRLCS KTQGCKQDTL LLAKKMNGYQ RRIKNATEKM MALVAELSMK QALTIELQKE
VREKEDFIFT CNSRIEKGLP LNKEIEKEWL KVLRDEEMHA LAIAEKSQEF LEADNRQLPN
GVYTTAEQRP NAYIPEADAT LPLPKPYGAL APFKPSEPGA NMRHIRKPVI KPVEI
