ID   CC146_RAT               Reviewed;         974 AA.
AC   Q66H60;
DT   05-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 72.
DE   RecName: Full=Coiled-coil domain-containing protein 146;
GN   Name=Ccdc146;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-12, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=22673903; DOI=10.1038/ncomms1871;
RA   Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C.,
RA   Olsen J.V.;
RT   "Quantitative maps of protein phosphorylation sites across 14 different rat
RT   organs and tissues.";
RL   Nat. Commun. 3:876-876(2012).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, microtubule organizing
CC       center, centrosome {ECO:0000250|UniProtKB:Q8IYE0}.
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DR   EMBL; BC082003; AAH82003.1; -; mRNA.
DR   RefSeq; NP_001020215.1; NM_001025044.1.
DR   AlphaFoldDB; Q66H60; -.
DR   SMR; Q66H60; -.
DR   STRING; 10116.ENSRNOP00000017374; -.
DR   iPTMnet; Q66H60; -.
DR   PhosphoSitePlus; Q66H60; -.
DR   PaxDb; Q66H60; -.
DR   PRIDE; Q66H60; -.
DR   Ensembl; ENSRNOT00000017374; ENSRNOP00000017374; ENSRNOG00000012932.
DR   GeneID; 499980; -.
DR   KEGG; rno:499980; -.
DR   CTD; 57639; -.
DR   RGD; 1559535; Ccdc146.
DR   eggNOG; ENOG502QPM4; Eukaryota.
DR   GeneTree; ENSGT00530000063534; -.
DR   InParanoid; Q66H60; -.
DR   OrthoDB; 135458at2759; -.
DR   PhylomeDB; Q66H60; -.
DR   PRO; PR:Q66H60; -.
DR   Proteomes; UP000002494; Chromosome 4.
DR   GO; GO:0005814; C:centriole; ISS:UniProtKB.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005856; C:cytoskeleton; IBA:GO_Central.
PE   1: Evidence at protein level;
KW   Coiled coil; Cytoplasm; Cytoskeleton; Phosphoprotein; Reference proteome.
FT   CHAIN           1..974
FT                   /note="Coiled-coil domain-containing protein 146"
FT                   /id="PRO_0000317253"
FT   REGION          1..44
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          105..160
FT                   /evidence="ECO:0000255"
FT   COILED          195..340
FT                   /evidence="ECO:0000255"
FT   COILED          421..474
FT                   /evidence="ECO:0000255"
FT   COILED          512..660
FT                   /evidence="ECO:0000255"
FT   COILED          687..712
FT                   /evidence="ECO:0000255"
FT   COILED          767..848
FT                   /evidence="ECO:0000255"
FT   MOD_RES         12
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:22673903"
SQ   SEQUENCE   974 AA;  114645 MW;  174B5359B1A9DF9D CRC64;
     MEDRSKYIAE ESEDEEDEEQ EEKEKKGGAS TSTETEEDQE DIPSVIVPTI NIREERLVDL
     AQTPAFLCLN ELHTSGKLPG TRMAELKAKY TLLHDTVVST QESEVQLLEN AKRFTEQIQQ
     QQVRLQEADD FPNVFTTEVS KLREQLLKYQ NEYTAVQERE YHTQYRLNSL TEEKSLVLKE
     FEKIPKPGEI EKKTKLLKES TEELRKEVIQ KRLEIKNLRE DVVSKQKQLM KEQKELEELM
     DYQVGLKDDV VHHQSVPVQI TKEIEKLTRR KIETEKKNVV LEFELKELSD SLKKLENKVS
     ALAEERDDTI KEVEGKRTLL EVKEREYGQL LKLLELTKEN EASSLAERGI LDINLRNCLM
     DKQNYHDELS RKQREKERDF RNLKKTELLL KVSLDALSQA QALNQRLLLE MEAIPKEDLL
     LPEQRKELHK EVDLAKRNLA QQRSLSEAEA KLVEQQIAEE NKLLKEQETM REVLFNLGRM
     TQIKMEEKEQ KAKDFLKSQR RYCDIIKEIK SKKLEIRLYR KRKREIHRRL KEFAGLYDAI
     RNERNKFVNL LHKAYQKVNE IKERLKMSLN ELEILRSSAV SQERKLQNAM LKHSNNVTIR
     ESMQNDVCKI TAKLQEMKEK KEAQLTSMDR LASMITVIEE EMVQLRKKYE KAVQRRNESG
     VQLIEREEEV CIFYEKMNIQ DKVKLHQDIE IHILEEKIRF LKLKVAEKQR QICVTQKLVP
     IKKSLDANLA VVQIQFSQCA DRIKALEKCF VNPDCQGRVR FIPGKDLTEE EMIKKLDMLE
     LQLAKKEEKL LEKDFIYEQV SQLTNRLKTK TQACKMDTLL LAKKMNSYQK KIKDVTQEMM
     ALVAELSMKQ ALTIELQKEV REKEEFIFSC SSRIEKGLPL NREIEKDWLK VLRDEEMYAF
     ATAEKTREYI DTDYRQLPNG VYTTAEQRPN AYIPETDATL PLPKPYGALA PFKPSEPGAN
     RRHIRKPIIK PIEI