CC148_MOUSE
ID CC148_MOUSE Reviewed; 527 AA.
AC Q6P5U8; A2APN1; Q8CDB5;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 92.
DE RecName: Full=Coiled-coil domain-containing protein 148;
GN Name=Ccdc148;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P5U8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P5U8-2; Sequence=VSP_032537, VSP_032538;
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DR EMBL; AK030792; BAC27139.1; -; mRNA.
DR EMBL; AL844163; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL929070; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR626863; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC062650; AAH62650.1; -; mRNA.
DR CCDS; CCDS50587.1; -. [Q6P5U8-1]
DR RefSeq; NP_001001178.1; NM_001001178.1. [Q6P5U8-1]
DR RefSeq; XP_017172996.1; XM_017317507.1. [Q6P5U8-1]
DR AlphaFoldDB; Q6P5U8; -.
DR STRING; 10090.ENSMUSP00000076871; -.
DR PhosphoSitePlus; Q6P5U8; -.
DR PaxDb; Q6P5U8; -.
DR PRIDE; Q6P5U8; -.
DR Antibodypedia; 33710; 83 antibodies from 17 providers.
DR Ensembl; ENSMUST00000077687; ENSMUSP00000076871; ENSMUSG00000036641. [Q6P5U8-1]
DR GeneID; 227933; -.
DR KEGG; mmu:227933; -.
DR UCSC; uc008jsy.1; mouse. [Q6P5U8-2]
DR UCSC; uc029txn.1; mouse. [Q6P5U8-1]
DR CTD; 130940; -.
DR MGI; MGI:3039583; Ccdc148.
DR VEuPathDB; HostDB:ENSMUSG00000036641; -.
DR eggNOG; ENOG502QV5F; Eukaryota.
DR GeneTree; ENSGT00940000153988; -.
DR HOGENOM; CLU_032590_0_0_1; -.
DR InParanoid; Q6P5U8; -.
DR OMA; GMRSTKY; -.
DR PhylomeDB; Q6P5U8; -.
DR TreeFam; TF332726; -.
DR BioGRID-ORCS; 227933; 0 hits in 57 CRISPR screens.
DR ChiTaRS; Ccdc148; mouse.
DR PRO; PR:Q6P5U8; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q6P5U8; protein.
DR Bgee; ENSMUSG00000036641; Expressed in spermatocyte and 62 other tissues.
DR ExpressionAtlas; Q6P5U8; baseline and differential.
DR InterPro; IPR039902; CCDC148/CCDC112.
DR PANTHER; PTHR21549; PTHR21549; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..527
FT /note="Coiled-coil domain-containing protein 148"
FT /id="PRO_0000326065"
FT COILED 289..353
FT /evidence="ECO:0000255"
FT COILED 401..438
FT /evidence="ECO:0000255"
FT VAR_SEQ 1..359
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032537"
FT VAR_SEQ 480..527
FT /note="IISDPRLRFELALREAGLHKTQYAKEMLPKIGPQKPPRKDTESTVFKV ->
FT VLMGIALLVQSLG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_032538"
SQ SEQUENCE 527 AA; 63396 MW; 1AD00AD5013B4ACA CRC64;
MLIKQHKQVW WQEQERLKGI RCKLESEIRS CLNEESIGSE CFCELMNFEK ELSEEWCAYL
TAVIDPIQQL RTGLKRWYPT SQSAPCHEGS DATEVLEEVD FVKKQSKAAF ERLHQEQWHL
EEDLLDLSVK LLDHSSEEKP NLLSEQPMEL VTLDCPYPDL KSSILNEFCN FTERYQEKLE
DFDLQLEDIR SNFQLSAEEH WTYQAVLDQY PGNLLGRRAL YLDMLQRYFP HKSRHHLVEH
EKYCDQYHFA REQRRILIDN WSRSRKDFIQ KAMLTLLEAC AAHEMGSLLA KDRRRQQELC
ADLKAKVSQW RAQQEELSRL EMEISARRRE REEEKEKLWK KKELLRREET EIKIRKYWAM
KQQKWQEMEK RDLRRLEELK KLMAEQSVKD RERVKYRQEL LEKRLMERKK LALQEVQEEE
ERERRLEALR KQVAVAVQSD PVRMMSETLA WKARTGSESE EEFILQKPLF TLTTYNEQQI
ISDPRLRFEL ALREAGLHKT QYAKEMLPKI GPQKPPRKDT ESTVFKV
