ID   CC149_CAEEL             Reviewed;         369 AA.
AC   Q93635;
DT   15-MAR-2017, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Coiled-coil domain-containing protein 149 {ECO:0000312|WormBase:F29G6.2};
GN   Name=ccdc-149 {ECO:0000303|PubMed:27930654, ECO:0000312|WormBase:F29G6.2};
GN   ORFNames=F29G6.2 {ECO:0000312|WormBase:F29G6.2};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN   [1] {ECO:0000312|Proteomes:UP000001940}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=27930654; DOI=10.1371/journal.pgen.1006469;
RA   Jensen V.L., Carter S., Sanders A.A., Li C., Kennedy J., Timbers T.A.,
RA   Cai J., Scheidel N., Kennedy B.N., Morin R.D., Leroux M.R., Blacque O.E.;
RT   "Whole-organism developmental expression profiling identifies rab-28 as a
RT   novel ciliary GTPase associated with the BBSome and intraflagellar
RT   transport.";
RL   PLoS Genet. 12:E1006469-E1006469(2016).
CC   -!- SUBCELLULAR LOCATION: Cell projection, cilium
CC       {ECO:0000269|PubMed:27930654}. Note=Localizes to the base of the
CC       cilium. {ECO:0000269|PubMed:27930654}.
CC   -!- TISSUE SPECIFICITY: Expressed in amphid and phasmid ciliated neurons,
CC       and also pharyngeal, touch receptor and motor neurons.
CC       {ECO:0000269|PubMed:27930654}.
CC   -!- SIMILARITY: Belongs to the CCDC149 family. {ECO:0000305}.
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DR   EMBL; BX284606; CAB01752.1; -; Genomic_DNA.
DR   PIR; T21556; T21556.
DR   RefSeq; NP_509921.1; NM_077520.1.
DR   AlphaFoldDB; Q93635; -.
DR   SMR; Q93635; -.
DR   DIP; DIP-24925N; -.
DR   IntAct; Q93635; 1.
DR   STRING; 6239.F29G6.2; -.
DR   EPD; Q93635; -.
DR   PaxDb; Q93635; -.
DR   EnsemblMetazoa; F29G6.2.1; F29G6.2.1; WBGene00009258.
DR   GeneID; 185121; -.
DR   KEGG; cel:CELE_F29G6.2; -.
DR   UCSC; F29G6.2; c. elegans.
DR   CTD; 185121; -.
DR   WormBase; F29G6.2; CE09792; WBGene00009258; ccdc-149.
DR   eggNOG; KOG4687; Eukaryota.
DR   GeneTree; ENSGT00390000015958; -.
DR   HOGENOM; CLU_076968_0_0_1; -.
DR   InParanoid; Q93635; -.
DR   OMA; THKQVEQ; -.
DR   OrthoDB; 697466at2759; -.
DR   PhylomeDB; Q93635; -.
DR   PRO; PR:Q93635; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00009258; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR   GO; GO:0097546; C:ciliary base; IDA:UniProtKB.
DR   InterPro; IPR019179; Coiled-coil_dom-contain_pr_149.
DR   PANTHER; PTHR21682; PTHR21682; 1.
DR   Pfam; PF09789; DUF2353; 1.
PE   2: Evidence at transcript level;
KW   Cell projection; Cilium; Coiled coil; Reference proteome.
FT   CHAIN           1..369
FT                   /note="Coiled-coil domain-containing protein 149"
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000439159"
FT   COILED          1..249
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   369 AA;  42086 MW;  E6E875D55995A15D CRC64;
     MKENNNAEIL ELKKQFTALQ QKCGAKTDTI VRLGQDLEKS ENEKKGLAAR VETLERNLER
     SERELQLVCA CQNDMKIKFG TERQDLIEDI EKYKRENQQL RTDRQELLDQ KADLKKDCKT
     FRQTIAQFEV EKMGGPVRNS FSTENDEVSK LEAHEKLQAK CKGLESDLRS MLGIKEELLM
     ERDEMQRKVA RLSNELSYLL NGDPRRVAED LDSLVAENRF LKAKLNTAEE ESESIKMTLA
     KYKQMAEAVN VQTMVNRSPK AGEGDDKPSV AVINMKQIRE LLASHAIELV ESDYRAITTI
     LLDLCNDKQM ALAHSRRANK VLGMRLHEVE SKLAVLDIKS RSSSPRHELP RDEDIELVVP
     KAVASTSSK