ZAR1L_HUMAN
ID ZAR1L_HUMAN Reviewed; 321 AA.
AC A6NP61; B2RV03; B7ZBU2;
DT 29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 15-JAN-2008, sequence version 2.
DT 03-AUG-2022, entry version 101.
DE RecName: Full=ZAR1-like protein;
GN Name=ZAR1L;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057823; DOI=10.1038/nature02379;
RA Dunham A., Matthews L.H., Burton J., Ashurst J.L., Howe K.L.,
RA Ashcroft K.J., Beare D.M., Burford D.C., Hunt S.E., Griffiths-Jones S.,
RA Jones M.C., Keenan S.J., Oliver K., Scott C.E., Ainscough R., Almeida J.P.,
RA Ambrose K.D., Andrews D.T., Ashwell R.I.S., Babbage A.K., Bagguley C.L.,
RA Bailey J., Bannerjee R., Barlow K.F., Bates K., Beasley H., Bird C.P.,
RA Bray-Allen S., Brown A.J., Brown J.Y., Burrill W., Carder C., Carter N.P.,
RA Chapman J.C., Clamp M.E., Clark S.Y., Clarke G., Clee C.M., Clegg S.C.,
RA Cobley V., Collins J.E., Corby N., Coville G.J., Deloukas P., Dhami P.,
RA Dunham I., Dunn M., Earthrowl M.E., Ellington A.G., Faulkner L.,
RA Frankish A.G., Frankland J., French L., Garner P., Garnett J.,
RA Gilbert J.G.R., Gilson C.J., Ghori J., Grafham D.V., Gribble S.M.,
RA Griffiths C., Hall R.E., Hammond S., Harley J.L., Hart E.A., Heath P.D.,
RA Howden P.J., Huckle E.J., Hunt P.J., Hunt A.R., Johnson C., Johnson D.,
RA Kay M., Kimberley A.M., King A., Laird G.K., Langford C.J., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Lloyd C., Loveland J.E., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., McLaren S.J., McMurray A., Milne S.,
RA Moore M.J.F., Nickerson T., Palmer S.A., Pearce A.V., Peck A.I., Pelan S.,
RA Phillimore B., Porter K.M., Rice C.M., Searle S., Sehra H.K., Shownkeen R.,
RA Skuce C.D., Smith M., Steward C.A., Sycamore N., Tester J., Thomas D.W.,
RA Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P.,
RA Whitehead S.L., Willey D.L., Wilming L., Wray P.W., Wright M.W., Young L.,
RA Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Beck S., Bentley D.R.,
RA Rogers J., Ross M.T.;
RT "The DNA sequence and analysis of human chromosome 13.";
RL Nature 428:522-528(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SIMILARITY: Belongs to the ZAR1 family. {ECO:0000305}.
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DR EMBL; AL445212; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC146956; AAI46957.1; -; mRNA.
DR EMBL; BC146965; AAI46966.1; -; mRNA.
DR CCDS; CCDS45023.1; -.
DR RefSeq; NP_001130043.1; NM_001136571.1.
DR AlphaFoldDB; A6NP61; -.
DR BioGRID; 571620; 23.
DR STRING; 9606.ENSP00000437289; -.
DR iPTMnet; A6NP61; -.
DR PhosphoSitePlus; A6NP61; -.
DR BioMuta; ZAR1L; -.
DR MassIVE; A6NP61; -.
DR PaxDb; A6NP61; -.
DR PeptideAtlas; A6NP61; -.
DR PRIDE; A6NP61; -.
DR ProteomicsDB; 1661; -.
DR Antibodypedia; 49134; 41 antibodies from 10 providers.
DR DNASU; 646799; -.
DR Ensembl; ENST00000345108.6; ENSP00000344616.5; ENSG00000189167.12.
DR Ensembl; ENST00000533490.7; ENSP00000437289.2; ENSG00000189167.12.
DR GeneID; 646799; -.
DR KEGG; hsa:646799; -.
DR MANE-Select; ENST00000533490.7; ENSP00000437289.2; NM_001136571.2; NP_001130043.1.
DR UCSC; uc010abc.1; human.
DR CTD; 646799; -.
DR DisGeNET; 646799; -.
DR GeneCards; ZAR1L; -.
DR HGNC; HGNC:37116; ZAR1L.
DR HPA; ENSG00000189167; Not detected.
DR neXtProt; NX_A6NP61; -.
DR OpenTargets; ENSG00000189167; -.
DR PharmGKB; PA165505636; -.
DR VEuPathDB; HostDB:ENSG00000189167; -.
DR eggNOG; ENOG502QWC9; Eukaryota.
DR GeneTree; ENSGT00390000012305; -.
DR HOGENOM; CLU_053350_1_0_1; -.
DR InParanoid; A6NP61; -.
DR OMA; QCSLGPQ; -.
DR OrthoDB; 822936at2759; -.
DR PhylomeDB; A6NP61; -.
DR TreeFam; TF331383; -.
DR PathwayCommons; A6NP61; -.
DR BioGRID-ORCS; 646799; 11 hits in 1059 CRISPR screens.
DR ChiTaRS; ZAR1L; human.
DR GenomeRNAi; 646799; -.
DR Pharos; A6NP61; Tdark.
DR PRO; PR:A6NP61; -.
DR Proteomes; UP000005640; Chromosome 13.
DR RNAct; A6NP61; protein.
DR Bgee; ENSG00000189167; Expressed in right testis and 11 other tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IEA:GOC.
DR GO; GO:0006412; P:translation; IBA:GO_Central.
DR InterPro; IPR026775; Zar1.
DR InterPro; IPR027377; Znf-3CxxC.
DR PANTHER; PTHR31054; PTHR31054; 1.
DR Pfam; PF13695; zf-3CxxC; 1.
DR SMART; SM01328; zf-3CxxC; 1.
PE 2: Evidence at transcript level;
KW Reference proteome.
FT CHAIN 1..321
FT /note="ZAR1-like protein"
FT /id="PRO_0000332227"
FT REGION 110..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 141..155
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..196
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 321 AA; 36010 MW; B5229FDB8FD581BC CRC64;
MERFVRVPYG LYQGYGSTVP LGQPGLSGHK QPDWRQNMGP PTFLARPGLL VPANAPDYCI
DPYKRAQLKA ILSQMNPSLS PRLCKPNTKE VGVQVSPRVD KAVQCSLGPR TLSSCSPWDG
RDPQEPLPAC GVTSPATGRR GLIRLRRDGD EAESKALPGP AEASQPQPPS RRSGADRQEE
PGQLEESGEK DAPCPQETKS KQVPGDAASE PLRRPNFQFL EPKYGYFHCK DCKTRWESAY
VWCISGTNKV YFKQLCCKCQ KSFNPYRVEA IQCQTCSKSH CSCPQKKRHI DLRRPHRQEL
CGRCKDKRFS CGNIYSFKYV M
