ID   ZAR1_DANRE              Reviewed;         329 AA.
AC   Q7T3T8;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Zygote arrest protein 1;
DE   AltName: Full=Oocyte-specific maternal effect factor;
GN   Name=zar1;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Ovary;
RX   PubMed=12773403; DOI=10.1095/biolreprod.103.016022;
RA   Wu X., Wang P., Brown C.A., Zilinski C.A., Matzuk M.M.;
RT   "Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in
RT   vertebrate ovaries.";
RL   Biol. Reprod. 69:861-867(2003).
CC   -!- FUNCTION: Essential for female fertility. May play a role in the
CC       oocyte-to-embryo transition (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZAR1 family. {ECO:0000305}.
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DR   EMBL; AY283178; AAP37040.1; -; mRNA.
DR   AlphaFoldDB; Q7T3T8; -.
DR   STRING; 7955.ENSDARP00000022641; -.
DR   PaxDb; Q7T3T8; -.
DR   PRIDE; Q7T3T8; -.
DR   ZFIN; ZDB-GENE-030818-1; zar1.
DR   eggNOG; ENOG502QWC9; Eukaryota.
DR   InParanoid; Q7T3T8; -.
DR   PhylomeDB; Q7T3T8; -.
DR   PRO; PR:Q7T3T8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0032991; C:protein-containing complex; IPI:ZFIN.
DR   GO; GO:1903231; F:mRNA base-pairing post-transcriptional repressor activity; IDA:ZFIN.
DR   GO; GO:0003729; F:mRNA binding; IDA:ZFIN.
DR   GO; GO:0017148; P:negative regulation of translation; IDA:ZFIN.
DR   GO; GO:1905881; P:positive regulation of oogenesis; IMP:ZFIN.
DR   GO; GO:0006412; P:translation; IMP:ZFIN.
DR   InterPro; IPR026775; Zar1.
DR   InterPro; IPR027377; Znf-3CxxC.
DR   PANTHER; PTHR31054; PTHR31054; 1.
DR   Pfam; PF13695; zf-3CxxC; 1.
DR   SMART; SM01328; zf-3CxxC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Reference proteome.
FT   CHAIN           1..329
FT                   /note="Zygote arrest protein 1"
FT                   /id="PRO_0000187014"
FT   REGION          106..132
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          146..218
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        162..181
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        187..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        204..218
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   329 AA;  38256 MW;  4DBE44D2B3529F40 CRC64;
     MATYGNETVD NYLYSSYNPY YYKYPKFKGW RQKAYFTNYG EGETYFDNHH RAQLKSILSQ
     INPNLTPRLR KANTKDVGVQ VNPKTDASIQ CSLGPRTLLA RKRDALRRRR QEVQTPGSPV
     SSGGVRFPRT QAVYSPVESR RLVSLFREEG EEEEDTDLEV TETVDSAEKL ESAEKNVRKQ
     GKKSAKQPLS PEKNINKQTE TNEENTNEPV KTEQDDLKSK ARVRFQSLEQ KYGFYHCKDC
     NLRWESAYVW CVQGTNKVYF KQFCRTCQKS FNPYRVEDIA CQTCKKARCT CSVKSRHVDP
     KRPHRQDLCG RCKGKRLSCD STFSFKYII