ID   ZAR1_HUMAN              Reviewed;         424 AA.
AC   Q86SH2;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 116.
DE   RecName: Full=Zygote arrest protein 1;
DE   AltName: Full=Oocyte-specific maternal effect factor;
GN   Name=ZAR1;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RX   PubMed=12539046; DOI=10.1038/ng1079;
RA   Wu X., Viveiros M.M., Eppig J.J., Bai Y., Fitzpatrick S.L., Matzuk M.M.;
RT   "Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the
RT   oocyte-to-embryo transition.";
RL   Nat. Genet. 33:187-191(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12773403; DOI=10.1095/biolreprod.103.016022;
RA   Wu X., Wang P., Brown C.A., Zilinski C.A., Matzuk M.M.;
RT   "Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in
RT   vertebrate ovaries.";
RL   Biol. Reprod. 69:861-867(2003).
CC   -!- FUNCTION: Essential for female fertility. May play a role in the
CC       oocyte-to-embryo transition (By similarity). {ECO:0000250}.
CC   -!- INTERACTION:
CC       Q86SH2; Q96FJ2: DYNLL2; NbExp=3; IntAct=EBI-18679381, EBI-742371;
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Ovary and testis. {ECO:0000269|PubMed:12539046}.
CC   -!- SIMILARITY: Belongs to the ZAR1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY191416; AAO24707.1; -; mRNA.
DR   EMBL; AY193890; AAO24709.1; -; Genomic_DNA.
DR   CCDS; CCDS3483.1; -.
DR   RefSeq; NP_783318.1; NM_175619.2.
DR   AlphaFoldDB; Q86SH2; -.
DR   BioGRID; 130576; 1.
DR   IntAct; Q86SH2; 1.
DR   STRING; 9606.ENSP00000329803; -.
DR   iPTMnet; Q86SH2; -.
DR   PhosphoSitePlus; Q86SH2; -.
DR   BioMuta; ZAR1; -.
DR   DMDM; 45477298; -.
DR   MassIVE; Q86SH2; -.
DR   PaxDb; Q86SH2; -.
DR   PeptideAtlas; Q86SH2; -.
DR   PRIDE; Q86SH2; -.
DR   ProteomicsDB; 69590; -.
DR   Antibodypedia; 67975; 130 antibodies from 18 providers.
DR   DNASU; 326340; -.
DR   Ensembl; ENST00000327939.4; ENSP00000329803.4; ENSG00000182223.7.
DR   GeneID; 326340; -.
DR   KEGG; hsa:326340; -.
DR   MANE-Select; ENST00000327939.4; ENSP00000329803.4; NM_175619.3; NP_783318.1.
DR   UCSC; uc003gyd.4; human.
DR   CTD; 326340; -.
DR   DisGeNET; 326340; -.
DR   GeneCards; ZAR1; -.
DR   HGNC; HGNC:20436; ZAR1.
DR   HPA; ENSG00000182223; Group enriched (brain, testis).
DR   MIM; 607520; gene.
DR   neXtProt; NX_Q86SH2; -.
DR   OpenTargets; ENSG00000182223; -.
DR   PharmGKB; PA134938240; -.
DR   VEuPathDB; HostDB:ENSG00000182223; -.
DR   eggNOG; ENOG502QWC9; Eukaryota.
DR   GeneTree; ENSGT00390000012305; -.
DR   HOGENOM; CLU_053350_0_0_1; -.
DR   InParanoid; Q86SH2; -.
DR   OMA; FNNHQRA; -.
DR   OrthoDB; 822936at2759; -.
DR   PhylomeDB; Q86SH2; -.
DR   TreeFam; TF331383; -.
DR   PathwayCommons; Q86SH2; -.
DR   SignaLink; Q86SH2; -.
DR   BioGRID-ORCS; 326340; 13 hits in 1067 CRISPR screens.
DR   ChiTaRS; ZAR1; human.
DR   GenomeRNAi; 326340; -.
DR   Pharos; Q86SH2; Tbio.
DR   PRO; PR:Q86SH2; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q86SH2; protein.
DR   Bgee; ENSG00000182223; Expressed in secondary oocyte and 25 other tissues.
DR   Genevisible; Q86SH2; HS.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IEA:GOC.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   InterPro; IPR026775; Zar1.
DR   InterPro; IPR027377; Znf-3CxxC.
DR   PANTHER; PTHR31054; PTHR31054; 1.
DR   Pfam; PF13695; zf-3CxxC; 1.
DR   SMART; SM01328; zf-3CxxC; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Developmental protein; Reference proteome.
FT   CHAIN           1..424
FT                   /note="Zygote arrest protein 1"
FT                   /id="PRO_0000187011"
FT   REGION          125..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          196..313
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        225..243
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   424 AA;  45873 MW;  81CEF693C5BA14A5 CRC64;
     MAALGDEVLD GYVFPACPPC SYRYPYPAAT KGKGAAGGSW QQRGRGCLPA SSPCSAGAAS
     LSFPGCGRLT AAEYFDSYQR ERLMALLAQV GPGLGPRARR AGSCDVAVQV SPRIDAAVQC
     SLGRRTLQRR ARDPESPAGP GAEGTTGGGS FSQQPSRRGL EQGSPQNGAP RPMRFPRTVA
     VYSPLALRRL TAFLEGPGPA AGEQRSGASD GERGPPPARL QGPEEGEVWT KKAPRRPQSD
     DDGEAQAAVR ASWEQPADGP ELPPREAQEG EAAPRSALRS PGQPPSAGRA RDGGDGREAA
     VAGEGPSPRS PELGKERLRF QFLEQKYGYY HCKDCNIRWE SAYVWCVQGT NKVYFKQFCR
     TCQKSYNPYR VEDITCQSCK QTRCSCPVKL RHVDPKRPHR QDLCGRCKGK RLSCDSTFSF
     KYII