CC149_HUMAN
ID CC149_HUMAN Reviewed; 474 AA.
AC Q6ZUS6; A6NJE7; B4DK90; B4DZG3; G5EA04; Q6NW41; Q8N3K8;
DT 22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT 22-JUL-2008, sequence version 2.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Coiled-coil domain-containing protein 149;
GN Name=CCDC149;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 5 AND 6).
RC TISSUE=Teratocarcinoma, Testis, and Thalamus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q6ZUS6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6ZUS6-2; Sequence=VSP_042498, VSP_034743;
CC Name=3;
CC IsoId=Q6ZUS6-3; Sequence=VSP_042498, VSP_034741, VSP_034742;
CC Name=4;
CC IsoId=Q6ZUS6-4; Sequence=VSP_042498;
CC Name=5;
CC IsoId=Q6ZUS6-5; Sequence=VSP_042499;
CC Name=6;
CC IsoId=Q6ZUS6-6; Sequence=VSP_042500;
CC -!- SIMILARITY: Belongs to the CCDC149 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH57761.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH67735.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC86142.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAC86142.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK125353; BAC86142.1; ALT_SEQ; mRNA.
DR EMBL; AK296454; BAG59102.1; -; mRNA.
DR EMBL; AK302905; BAG64075.1; -; mRNA.
DR EMBL; AL834257; CAD38932.1; -; mRNA.
DR EMBL; AC006390; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC113614; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC116422; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471069; EAW92824.1; -; Genomic_DNA.
DR EMBL; CH471069; EAW92825.1; -; Genomic_DNA.
DR EMBL; BC067735; AAH67735.1; ALT_INIT; mRNA.
DR EMBL; BC057761; AAH57761.1; ALT_INIT; mRNA.
DR CCDS; CCDS33967.2; -. [Q6ZUS6-5]
DR RefSeq; NP_001124198.1; NM_001130726.3. [Q6ZUS6-4]
DR RefSeq; NP_001317572.1; NM_001330643.1.
DR RefSeq; NP_001317573.1; NM_001330644.1. [Q6ZUS6-1]
DR RefSeq; NP_775734.2; NM_173463.5. [Q6ZUS6-5]
DR RefSeq; XP_016864316.1; XM_017008827.1. [Q6ZUS6-5]
DR AlphaFoldDB; Q6ZUS6; -.
DR SMR; Q6ZUS6; -.
DR BioGRID; 124790; 4.
DR IntAct; Q6ZUS6; 4.
DR STRING; 9606.ENSP00000425715; -.
DR iPTMnet; Q6ZUS6; -.
DR PhosphoSitePlus; Q6ZUS6; -.
DR BioMuta; CCDC149; -.
DR DMDM; 205371874; -.
DR EPD; Q6ZUS6; -.
DR jPOST; Q6ZUS6; -.
DR MassIVE; Q6ZUS6; -.
DR PaxDb; Q6ZUS6; -.
DR PeptideAtlas; Q6ZUS6; -.
DR PRIDE; Q6ZUS6; -.
DR ProteomicsDB; 68349; -. [Q6ZUS6-1]
DR ProteomicsDB; 68350; -. [Q6ZUS6-2]
DR ProteomicsDB; 68351; -. [Q6ZUS6-3]
DR ProteomicsDB; 68352; -. [Q6ZUS6-4]
DR ProteomicsDB; 68353; -. [Q6ZUS6-5]
DR ProteomicsDB; 68354; -. [Q6ZUS6-6]
DR Antibodypedia; 65174; 29 antibodies from 9 providers.
DR DNASU; 91050; -.
DR Ensembl; ENST00000389609.8; ENSP00000374260.4; ENSG00000181982.19. [Q6ZUS6-5]
DR Ensembl; ENST00000502801.1; ENSP00000427529.1; ENSG00000181982.19. [Q6ZUS6-3]
DR Ensembl; ENST00000504487.5; ENSP00000425715.1; ENSG00000181982.19. [Q6ZUS6-4]
DR GeneID; 91050; -.
DR KEGG; hsa:91050; -.
DR UCSC; uc003grc.4; human. [Q6ZUS6-1]
DR CTD; 91050; -.
DR DisGeNET; 91050; -.
DR GeneCards; CCDC149; -.
DR HGNC; HGNC:25405; CCDC149.
DR HPA; ENSG00000181982; Low tissue specificity.
DR neXtProt; NX_Q6ZUS6; -.
DR OpenTargets; ENSG00000181982; -.
DR PharmGKB; PA162381560; -.
DR VEuPathDB; HostDB:ENSG00000181982; -.
DR eggNOG; KOG4687; Eukaryota.
DR GeneTree; ENSGT00390000015958; -.
DR HOGENOM; CLU_016190_2_0_1; -.
DR InParanoid; Q6ZUS6; -.
DR OrthoDB; 697466at2759; -.
DR PhylomeDB; Q6ZUS6; -.
DR TreeFam; TF319794; -.
DR PathwayCommons; Q6ZUS6; -.
DR SignaLink; Q6ZUS6; -.
DR BioGRID-ORCS; 91050; 11 hits in 1065 CRISPR screens.
DR ChiTaRS; CCDC149; human.
DR GenomeRNAi; 91050; -.
DR Pharos; Q6ZUS6; Tdark.
DR PRO; PR:Q6ZUS6; -.
DR Proteomes; UP000005640; Chromosome 4.
DR RNAct; Q6ZUS6; protein.
DR Bgee; ENSG00000181982; Expressed in parotid gland and 152 other tissues.
DR ExpressionAtlas; Q6ZUS6; baseline and differential.
DR Genevisible; Q6ZUS6; HS.
DR InterPro; IPR019179; Coiled-coil_dom-contain_pr_149.
DR PANTHER; PTHR21682; PTHR21682; 1.
DR Pfam; PF09789; DUF2353; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Coiled coil; Reference proteome.
FT CHAIN 1..474
FT /note="Coiled-coil domain-containing protein 149"
FT /id="PRO_0000344209"
FT REGION 301..388
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 405..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..199
FT /evidence="ECO:0000255"
FT COILED 259..286
FT /evidence="ECO:0000255"
FT COILED 385..414
FT /evidence="ECO:0000255"
FT COMPBIAS 302..318
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 323..343
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 360..374
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 1..72
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042500"
FT VAR_SEQ 1
FT /note="M -> MEEEAMNGDRTESDWQGLVSEYLVCKRKLESKKEALLILSKELDTCQ
FT QERDQYKLM (in isoform 2, isoform 3 and isoform 4)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:17974005"
FT /id="VSP_042498"
FT VAR_SEQ 1
FT /note="M -> MVVIVVVIIIIIARAATWDSEYLVCKRKLESKKEALLILSKELDTCQ
FT QERDQYKLM (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_042499"
FT VAR_SEQ 70..86
FT /note="LLRMTIAKQRLGDEAIG -> GRLRSKKKMKVVPLLRR (in isoform
FT 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034741"
FT VAR_SEQ 87..474
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_034742"
FT VAR_SEQ 268..474
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:17974005"
FT /id="VSP_034743"
FT CONFLICT 196
FT /note="R -> Q (in Ref. 1; BAG64075)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 474 AA; 52796 MW; FCB0B1188A9634C2 CRC64;
MANQLRERHQ SLKKKYRELI DGDPSLPPEK RKQANLAQLL RDSQDRNKHL GEEIKELQQR
LGEVQGDNKL LRMTIAKQRL GDEAIGVRHF AAHEREDLVQ QLERAKEQIE SLEHDLQASV
DELQDVKEER SSYQDKVERL NQELNHILSG HENRIIDVDA LCMENRYLQE RLKQLHEEVN
LLKSNIAKYK NALERRKNSK GQGKSSSSAL TGVLSAKQVQ DLLSEDHGCS LPATPQSISD
LKSLATALLE TIHEKNMVIQ HQRQTNKILG NRVAELEKKL RTLEVSGLWS LPGGKDTILF
SDPTLPSGQR SRSPLLKFVE QPTENKADPK DGEAQKQEED ESCAAAEALT APEDAGRPAV
NSPANQSRGN QCKLFHPSLP QLPSEEEVNS LGREIIKLTK EQAAAELEEV RRESPIEGQR
SETGPAPPGL AIQGELPKSH LDSFEASRPA AKASTPEDGK GIPEGGGMRS TVKT
