ID   ZAR1_MOUSE              Reviewed;         361 AA.
AC   Q80SU3; Q4FZK8;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Zygote arrest protein 1;
DE   AltName: Full=Oocyte-specific maternal effect factor;
GN   Name=Zar1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], FUNCTION, TISSUE SPECIFICITY,
RP   DEVELOPMENTAL STAGE, AND SUBCELLULAR LOCATION.
RC   STRAIN=129/SvEv; TISSUE=Ovary;
RX   PubMed=12539046; DOI=10.1038/ng1079;
RA   Wu X., Viveiros M.M., Eppig J.J., Bai Y., Fitzpatrick S.L., Matzuk M.M.;
RT   "Zygote arrest 1 (Zar1) is a novel maternal-effect gene critical for the
RT   oocyte-to-embryo transition.";
RL   Nat. Genet. 33:187-191(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE, AND TISSUE SPECIFICITY.
RC   TISSUE=Ovary;
RX   PubMed=12773403; DOI=10.1095/biolreprod.103.016022;
RA   Wu X., Wang P., Brown C.A., Zilinski C.A., Matzuk M.M.;
RT   "Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in
RT   vertebrate ovaries.";
RL   Biol. Reprod. 69:861-867(2003).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Essential for female fertility. May play a role in the
CC       oocyte-to-embryo transition. {ECO:0000269|PubMed:12539046}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12539046}.
CC   -!- TISSUE SPECIFICITY: Ovary. Expressed in primary oocytes (from primary
CC       through antral follicle stages) and during the progression from Meiosis
CC       I to Meiosis II. The mRNA is detected in growing oocytes (early primary
CC       follicle, type 3a) through fully grown oocytes (antral follicle, type
CC       8). {ECO:0000269|PubMed:12539046, ECO:0000269|PubMed:12773403}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in zygote at the one-cell embryo,
CC       markedly less abundant at the two-cell embryo.
CC       {ECO:0000269|PubMed:12539046}.
CC   -!- SIMILARITY: Belongs to the ZAR1 family. {ECO:0000305}.
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DR   EMBL; AY191415; AAO24706.1; -; mRNA.
DR   EMBL; AY193889; AAO24708.1; -; Genomic_DNA.
DR   EMBL; BC099399; AAH99399.1; -; mRNA.
DR   CCDS; CCDS19331.1; -.
DR   RefSeq; NP_777366.1; NM_174877.3.
DR   AlphaFoldDB; Q80SU3; -.
DR   STRING; 10090.ENSMUSP00000073221; -.
DR   iPTMnet; Q80SU3; -.
DR   PhosphoSitePlus; Q80SU3; -.
DR   PaxDb; Q80SU3; -.
DR   PRIDE; Q80SU3; -.
DR   ProteomicsDB; 298488; -.
DR   Antibodypedia; 67975; 130 antibodies from 18 providers.
DR   DNASU; 317755; -.
DR   Ensembl; ENSMUST00000073528; ENSMUSP00000073221; ENSMUSG00000063935.
DR   GeneID; 317755; -.
DR   KEGG; mmu:317755; -.
DR   UCSC; uc008xrp.1; mouse.
DR   CTD; 326340; -.
DR   MGI; MGI:2180337; Zar1.
DR   VEuPathDB; HostDB:ENSMUSG00000063935; -.
DR   eggNOG; ENOG502QWC9; Eukaryota.
DR   GeneTree; ENSGT00390000012305; -.
DR   HOGENOM; CLU_053350_0_0_1; -.
DR   InParanoid; Q80SU3; -.
DR   OMA; KECNIRW; -.
DR   OrthoDB; 822936at2759; -.
DR   PhylomeDB; Q80SU3; -.
DR   TreeFam; TF331383; -.
DR   BioGRID-ORCS; 317755; 2 hits in 70 CRISPR screens.
DR   ChiTaRS; Zar1; mouse.
DR   PRO; PR:Q80SU3; -.
DR   Proteomes; UP000000589; Chromosome 5.
DR   RNAct; Q80SU3; protein.
DR   Bgee; ENSMUSG00000063935; Expressed in oocyte and 44 other tissues.
DR   ExpressionAtlas; Q80SU3; baseline and differential.
DR   Genevisible; Q80SU3; MM.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IEA:GOC.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   InterPro; IPR026775; Zar1.
DR   InterPro; IPR027377; Znf-3CxxC.
DR   PANTHER; PTHR31054; PTHR31054; 1.
DR   Pfam; PF13695; zf-3CxxC; 1.
DR   SMART; SM01328; zf-3CxxC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Reference proteome.
FT   CHAIN           1..361
FT                   /note="Zygote arrest protein 1"
FT                   /id="PRO_0000187012"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          98..128
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          148..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        148..163
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        171..185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   361 AA;  39986 MW;  C34AE85F76839242 CRC64;
     MFPASTFHPC PHPYPQATKA GDGWRFGARG CRPAPPSFLP GYRQLMAAEY VDSHQRAQLM
     ALLSRMGPRS VSSRDAAVQV NPRRDASVQC SLGRRTLQPA GCRASPDARS GSCQPRGHAG
     AGRSPRSWQT VAPFSSVTFC GLSSSLEVAG GRQTPTKGEG SPASSGTREP EPREVAARKA
     VPQPRSEEGD VQAAGQAGWE QQPPPEDRNS VAAMQSEPGS EEPCPAAEMA QDPGDSDAPR
     DQASPQSTEQ DKERLRFQFL EQKYGYYHCK DCKIRWESAY VWCVQGTSKV YFKQFCRVCE
     KSYNPYRVED ITCQSCKRTR CACPVRLRHV DPKRPHRQDL CGRCKDKRLS CDSTFSFKYI
     I