ID   ZAR1_RAT                Reviewed;         361 AA.
AC   Q7TSX9;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 89.
DE   RecName: Full=Zygote arrest protein 1;
DE   AltName: Full=Oocyte-specific maternal effect factor;
GN   Name=Zar1;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=12773403; DOI=10.1095/biolreprod.103.016022;
RA   Wu X., Wang P., Brown C.A., Zilinski C.A., Matzuk M.M.;
RT   "Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in
RT   vertebrate ovaries.";
RL   Biol. Reprod. 69:861-867(2003).
CC   -!- FUNCTION: Essential for female fertility. May play a role in the
CC       oocyte-to-embryo transition (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ZAR1 family. {ECO:0000305}.
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DR   EMBL; AY283175; AAP37037.1; -; mRNA.
DR   RefSeq; NP_852050.1; NM_181385.2.
DR   AlphaFoldDB; Q7TSX9; -.
DR   STRING; 10116.ENSRNOP00000032032; -.
DR   PaxDb; Q7TSX9; -.
DR   Ensembl; ENSRNOT00000030610; ENSRNOP00000032032; ENSRNOG00000026150.
DR   GeneID; 353228; -.
DR   KEGG; rno:353228; -.
DR   UCSC; RGD:727972; rat.
DR   CTD; 326340; -.
DR   RGD; 727972; Zar1.
DR   eggNOG; ENOG502QWC9; Eukaryota.
DR   GeneTree; ENSGT00390000012305; -.
DR   HOGENOM; CLU_053350_0_0_1; -.
DR   InParanoid; Q7TSX9; -.
DR   OMA; KECNIRW; -.
DR   OrthoDB; 822936at2759; -.
DR   PhylomeDB; Q7TSX9; -.
DR   TreeFam; TF331383; -.
DR   PRO; PR:Q7TSX9; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000026150; Expressed in ovary.
DR   GO; GO:0005737; C:cytoplasm; ISO:RGD.
DR   GO; GO:0035194; P:post-transcriptional gene silencing by RNA; IEA:GOC.
DR   GO; GO:0000003; P:reproduction; NAS:RGD.
DR   GO; GO:0006412; P:translation; IBA:GO_Central.
DR   InterPro; IPR026775; Zar1.
DR   InterPro; IPR027377; Znf-3CxxC.
DR   PANTHER; PTHR31054; PTHR31054; 1.
DR   Pfam; PF13695; zf-3CxxC; 1.
DR   SMART; SM01328; zf-3CxxC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Reference proteome.
FT   CHAIN           1..361
FT                   /note="Zygote arrest protein 1"
FT                   /id="PRO_0000187013"
FT   REGION          68..129
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          142..252
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   361 AA;  40357 MW;  82911DFA9E720301 CRC64;
     MFPASTPHPC PHPYPPTAAK AGDGWRFGAR GCRPEPPSFL PGYRQLMAAE YFDSYQRAQL
     MALLSRMGPR PVSSRDAAVQ VNPRRDASVQ CSLGRRTLQP GRRRASPDAR PGSCQPRSPA
     RAGRPPRSWR TVALYSPVTF GGLSSSLEVA GDRQTPTKGE GRPAPTGTRE PEPGEVAVMK
     AVPQPQSEEG DVQAEGQDGQ EQPPREDPDS VAAMQSEPGS EEPPPAVEMA QDPSDVAASR
     DRASPQSTEQ DKERLRFQFL EQKYGYYHCK DCNIRWESAY VWCVQGTSKV YFKQFCRVCE
     KSYNPYRVED ITCQSCKRTR CACPVRLRHV DPKRPHRQDL CGRCKDKRLS CDSTFSFKYI
     I