ID   ZAR1_XENLA              Reviewed;         295 AA.
AC   Q7T3U0;
DT   15-MAR-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2003, sequence version 1.
DT   03-AUG-2022, entry version 62.
DE   RecName: Full=Zygote arrest protein 1;
DE   AltName: Full=Oocyte-specific maternal effect factor;
GN   Name=zar1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, AND
RP   SUBCELLULAR LOCATION.
RC   TISSUE=Ovary;
RX   PubMed=12773403; DOI=10.1095/biolreprod.103.016022;
RA   Wu X., Wang P., Brown C.A., Zilinski C.A., Matzuk M.M.;
RT   "Zygote arrest 1 (Zar1) is an evolutionarily conserved gene expressed in
RT   vertebrate ovaries.";
RL   Biol. Reprod. 69:861-867(2003).
CC   -!- FUNCTION: Essential for female fertility. May play a role in the
CC       oocyte-to-embryo transition (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:12773403}.
CC   -!- TISSUE SPECIFICITY: Ovary, lung and muscle.
CC       {ECO:0000269|PubMed:12773403}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in the mature egg through the tailbud
CC       stage. {ECO:0000269|PubMed:12773403}.
CC   -!- SIMILARITY: Belongs to the ZAR1 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY283176; AAP37038.1; -; mRNA.
DR   RefSeq; NP_001083958.1; NM_001090489.1.
DR   AlphaFoldDB; Q7T3U0; -.
DR   BioGRID; 100536; 2.
DR   GeneID; 399211; -.
DR   KEGG; xla:399211; -.
DR   CTD; 399211; -.
DR   Xenbase; XB-GENE-942430; zar1.S.
DR   OrthoDB; 822936at2759; -.
DR   Proteomes; UP000186698; Chromosome 1S.
DR   Bgee; 399211; Expressed in oocyte and 6 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR026775; Zar1.
DR   InterPro; IPR027377; Znf-3CxxC.
DR   PANTHER; PTHR31054; PTHR31054; 2.
DR   Pfam; PF13695; zf-3CxxC; 1.
DR   SMART; SM01328; zf-3CxxC; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Reference proteome.
FT   CHAIN           1..295
FT                   /note="Zygote arrest protein 1"
FT                   /id="PRO_0000187016"
FT   REGION          80..115
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          144..186
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        144..185
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   295 AA;  33963 MW;  C1D5E1DD1A6B1911 CRC64;
     MYPAYNPYSY RYLNPRNKGM SWRQKNYLAS YGDTGDYCDN YQRAQLKAIL SQVNPNLTPR
     LCRANTRDVG VQVNPRQDAS VQCSLGPRTL LRRRPGALRK PPPEQGSPAS PTKTVRFPRT
     IAVYSPVAAG RLAPFQDEGV NLEEKGEAVR SEGSEGGRQE GKQGDGEIKE QMKMDKTDEE
     EAAPAQTRPK FQFLEQKYGY YHCKDCNIRW ESAYVWCVQE TNKVYFKQFC RTCQKSYNPY
     RVEDIMCQSC KQTRCACPVK LRHVDPKRPH RQDLCGRCKG KRLSCDSTFS FKYII