ZAS1_SCHPO
ID ZAS1_SCHPO Reviewed; 897 AA.
AC Q9UTS5; Q9UTS4; Q9UU54;
DT 10-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Zinc finger protein zas1;
GN Name=zas1; ORFNames=SPBC1198.04c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=972 / ATCC 24843;
RX PubMed=10718196; DOI=10.1093/dnares/7.1.27;
RA Okazaki K., Niwa O.;
RT "mRNAs encoding zinc finger protein isoforms are expressed by alternative
RT splicing of an in-frame intron in fission yeast.";
RL DNA Res. 7:27-30(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] OF 163-316, AND SUBCELLULAR
RP LOCATION.
RC STRAIN=ATCC 38364 / 968;
RX PubMed=10759889; DOI=10.1046/j.1365-2443.2000.00317.x;
RA Ding D.-Q., Tomita Y., Yamamoto A., Chikashige Y., Haraguchi T.,
RA Hiraoka Y.;
RT "Large-scale screening of intracellular protein localization in living
RT fission yeast cells by the use of a GFP-fusion genomic DNA library.";
RL Genes Cells 5:169-190(2000).
RN [4]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:10759889,
CC ECO:0000269|PubMed:16823372}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1; Synonyms=zas1B;
CC IsoId=Q9UTS5-1; Sequence=Displayed;
CC Name=2; Synonyms=zas1A;
CC IsoId=Q9UTS5-2; Sequence=VSP_016913;
CC -!- MISCELLANEOUS: [Isoform 1]: Minor transcript.
CC -!- MISCELLANEOUS: [Isoform 2]: Major transcript. {ECO:0000305}.
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DR EMBL; AF199436; AAF13703.1; -; mRNA.
DR EMBL; AF199437; AAF13704.1; -; mRNA.
DR EMBL; CU329671; CAB91179.1; -; Genomic_DNA.
DR EMBL; AB027804; BAA87108.1; -; Genomic_DNA.
DR RefSeq; NP_595073.1; NM_001020979.2.
DR AlphaFoldDB; Q9UTS5; -.
DR BioGRID; 276453; 9.
DR STRING; 4896.SPBC1198.04c.1; -.
DR iPTMnet; Q9UTS5; -.
DR MaxQB; Q9UTS5; -.
DR PaxDb; Q9UTS5; -.
DR PRIDE; Q9UTS5; -.
DR EnsemblFungi; SPBC1198.04c.1; SPBC1198.04c.1:pep; SPBC1198.04c. [Q9UTS5-1]
DR GeneID; 2539907; -.
DR KEGG; spo:SPBC1198.04c; -.
DR PomBase; SPBC1198.04c; zas1.
DR VEuPathDB; FungiDB:SPBC1198.04c; -.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_329005_0_0_1; -.
DR InParanoid; Q9UTS5; -.
DR OMA; NTENARY; -.
DR PhylomeDB; Q9UTS5; -.
DR PRO; PR:Q9UTS5; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0000785; C:chromatin; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IDA:PomBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; EXP:PomBase.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:PomBase.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:PomBase.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006351; P:transcription, DNA-templated; IEA:InterPro.
DR InterPro; IPR007219; Transcription_factor_dom_fun.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF04082; Fungal_trans; 1.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Alternative splicing; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Zinc; Zinc-finger.
FT CHAIN 1..897
FT /note="Zinc finger protein zas1"
FT /id="PRO_0000046860"
FT ZN_FING 26..50
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 56..79
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 93..119
FT /note="C2H2-type 3; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 89..141
FT /note="RMLNASCFLGFCVLAHDYVNLINARHFMIEHFLSLFAFCRTILFSLLTSFLL
FT V -> L (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:10718196"
FT /id="VSP_016913"
SQ SEQUENCE 897 AA; 102817 MW; 4B9F49DFBF6DA865 CRC64;
MSNEESFTEK PLKKRSRAHR LGDPRFYCTY PDCPKSFTRK EHLRRHERTH ENVKAFSCSF
CNRAFARSDV LNRHVQQMHL QKQNLSERRM LNASCFLGFC VLAHDYVNLI NARHFMIEHF
LSLFAFCRTI LFSLLTSFLL VPPPQFFHSE AGERPTPSVG APSSLASSMD SVRVAPSMLA
ASHQIVPQYS ENNPRVSNEP PRVTIENASL KPFSGYIKSH MSTSNFLNGE PDLNVNVDLS
PFPNLPATVP ITQAASTANA FQQPSNQFQT QKLPSGLDTR PVSSYPDELT QLESNPDSFS
RLDLQGDCTC IFKNRSSIAS SRTMDDVVRW LFSSGKRRQK YESSYPYQTQ SNQIPSQDQY
SDTDSNFLSY YFSASGPMYV PQKCPATVYN NLLNFLEGSF HLQPNFLAMF TLESVSSWLN
AYWSMFHVRW PILHRGTFQI TQAPLDLLLS MITLGMHSSN DLSIRSLAVE IHTTLRYNIY
QKQEFGPPVS LWVYQALFLI QVFELFTSNL KQHRLAQMFH PVLIEAMRQA IPSDALTVRS
ETFGESNTPL TLQQWHKWIT RESVKRIAFF VFALDSTSTL VFGNQPLLYV TDVSMPLLAE
EHHWEAENFE VWAAQKPTIE PPTILHMLKA FVQCEQCESP LPKLSPWNML LLLHGLLSVD
ISLKQKKFVP GMKLSKREID GWCSLVFEAY QKWNRCYYSI FLNNNILPFG HPFVKECRSL
YNLACIYSKT RLTYLQAFAK AVTDPVDGSV TSKTVAPLRY VKIWANTENA RYSTSNALEI
LDMLLREKIE SAPRYDTLIY HSWCYYVAAL VLWSIGFALD EENKKTEEVT NLHSQMSRYV
TKVRQALEQG EPLFAVVEKS KNPIILHVVL QALDVFPWDL LGEHKKIIQQ LLSKGND
