ZAT12_ARATH
ID ZAT12_ARATH Reviewed; 162 AA.
AC Q42410; Q8LA47;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Zinc finger protein ZAT12;
DE AltName: Full=Protein RESPONSIVE TO HIGH LIGHT 41;
GN Name=ZAT12; Synonyms=RHL41; OrderedLocusNames=At5g59820; ORFNames=MMN10.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia;
RX PubMed=9132053; DOI=10.1023/a:1005746803089;
RA Meissner R., Michael A.J.;
RT "Isolation and characterisation of a diverse family of Arabidopsis two and
RT three-fingered protein genes and cDNA's.";
RL Plant Mol. Biol. 33:615-624(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9872454; DOI=10.1093/dnares/5.5.297;
RA Nakamura Y., Sato S., Asamizu E., Kaneko T., Kotani H., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VII. Sequence
RT features of the regions of 1,013,767 bp covered by sixteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:297-308(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP FUNCTION.
RX PubMed=11069694; DOI=10.1046/j.1365-313x.2000.00864.x;
RA Iida A., Kazuoka T., Torikai S., Kikuchi H., Oeda K.;
RT "A zinc finger protein RHL41 mediates the light acclimatization response in
RT Arabidopsis.";
RL Plant J. 24:191-203(2000).
RN [7]
RP INDUCTION.
RX PubMed=12368499; DOI=10.1105/tpc.004747;
RA Klok E.J., Wilson I.W., Wilson D., Chapman S.C., Ewing R.M.,
RA Somerville S.C., Peacock W.J., Dolferus R., Dennis E.S.;
RT "Expression profile analysis of the low-oxygen response in Arabidopsis root
RT cultures.";
RL Plant Cell 14:2481-2494(2002).
RN [8]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=14722088; DOI=10.1074/jbc.m313350200;
RA Rizhsky L., Davletova S., Liang H., Mittler R.;
RT "The zinc finger protein Zat12 is required for cytosolic ascorbate
RT peroxidase 1 expression during oxidative stress in Arabidopsis.";
RL J. Biol. Chem. 279:11736-11743(2004).
RN [9]
RP FUNCTION, AND INDUCTION.
RX PubMed=15634197; DOI=10.1111/j.1365-313x.2004.02288.x;
RA Vogel J.T., Zarka D.G., Van Buskirk H.A., Fowler S.G., Thomashow M.F.;
RT "Roles of the CBF2 and ZAT12 transcription factors in configuring the low
RT temperature transcriptome of Arabidopsis.";
RL Plant J. 41:195-211(2005).
RN [10]
RP FUNCTION, INDUCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=16183833; DOI=10.1104/pp.105.068254;
RA Davletova S., Schlauch K., Coutu J., Mittler R.;
RT "The zinc-finger protein Zat12 plays a central role in reactive oxygen and
RT abiotic stress signaling in Arabidopsis.";
RL Plant Physiol. 139:847-856(2005).
RN [11]
RP INDUCTION BY HEAT STRESS.
RX PubMed=18201973; DOI=10.1074/jbc.m709187200;
RA Suzuki N., Bajad S., Shuman J., Shulaev V., Mittler R.;
RT "The transcriptional co-activator MBF1c is a key regulator of
RT thermotolerance in Arabidopsis thaliana.";
RL J. Biol. Chem. 283:9269-9275(2008).
RN [12]
RP INDUCTION BY CUCUMBER MOSAIC VIRUS.
RX PubMed=18922600; DOI=10.1016/j.jplph.2008.08.006;
RA Mitsuya Y., Takahashi Y., Berberich T., Miyazaki A., Matsumura H.,
RA Takahashi H., Terauchi R., Kusano T.;
RT "Spermine signaling plays a significant role in the defense response of
RT Arabidopsis thaliana to cucumber mosaic virus.";
RL J. Plant Physiol. 166:626-643(2009).
CC -!- FUNCTION: Transcriptional repressor involved in light acclimation, cold
CC and oxidative stress responses. May regulate a collection of
CC transcripts involved in response to high-light, cold and oxidative
CC stress. {ECO:0000269|PubMed:11069694, ECO:0000269|PubMed:14722088,
CC ECO:0000269|PubMed:15634197, ECO:0000269|PubMed:16183833}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in roots, stems and flowers.
CC {ECO:0000269|PubMed:9132053}.
CC -!- INDUCTION: By H(2)O(2), cold, drought, cold or heat stresses, wounding,
CC cucumber mosaic virus (CMV), exposure to high-intensity light and low-
CC oxygen conditions in roots. {ECO:0000269|PubMed:12368499,
CC ECO:0000269|PubMed:14722088, ECO:0000269|PubMed:15634197,
CC ECO:0000269|PubMed:16183833, ECO:0000269|PubMed:18201973,
CC ECO:0000269|PubMed:18922600}.
CC -!- DISRUPTION PHENOTYPE: No visible phenotype under normal growth
CC condition, but enhanced tolerance to heat stress and increased
CC sensitivity to salt stress. {ECO:0000269|PubMed:14722088,
CC ECO:0000269|PubMed:16183833}.
CC -!- MISCELLANEOUS: Plants overexpressing ZAT12 show thick and dark-green
CC leaves with round shape, short petiole, elevated amounts of
CC anthocyanins and enhanced tolerance to high-light irradiation and
CC oxidative stress.
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DR EMBL; X98673; CAA67231.1; -; mRNA.
DR EMBL; X98674; CAA67232.1; -; Genomic_DNA.
DR EMBL; AB015475; BAB08349.1; -; Genomic_DNA.
DR EMBL; CP002688; AED97237.1; -; Genomic_DNA.
DR EMBL; AY050915; AAK93592.1; -; mRNA.
DR EMBL; AY133818; AAM91752.1; -; mRNA.
DR EMBL; AY088036; AAM65582.1; -; mRNA.
DR RefSeq; NP_200790.1; NM_125374.3.
DR AlphaFoldDB; Q42410; -.
DR BioGRID; 21347; 2.
DR IntAct; Q42410; 1.
DR STRING; 3702.AT5G59820.1; -.
DR PaxDb; Q42410; -.
DR PRIDE; Q42410; -.
DR ProteomicsDB; 242346; -.
DR DNASU; 836103; -.
DR EnsemblPlants; AT5G59820.1; AT5G59820.1; AT5G59820.
DR GeneID; 836103; -.
DR Gramene; AT5G59820.1; AT5G59820.1; AT5G59820.
DR KEGG; ath:AT5G59820; -.
DR Araport; AT5G59820; -.
DR TAIR; locus:2168073; AT5G59820.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_059471_3_0_1; -.
DR InParanoid; Q42410; -.
DR OMA; RHRTTIN; -.
DR OrthoDB; 1412405at2759; -.
DR PhylomeDB; Q42410; -.
DR PRO; PR:Q42410; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q42410; baseline and differential.
DR Genevisible; Q42410; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR GO; GO:0009631; P:cold acclimation; IMP:TAIR.
DR GO; GO:0042538; P:hyperosmotic salinity response; IMP:TAIR.
DR GO; GO:0009643; P:photosynthetic acclimation; IMP:TAIR.
DR GO; GO:0010200; P:response to chitin; IEP:TAIR.
DR GO; GO:0009409; P:response to cold; IEP:TAIR.
DR GO; GO:0009408; P:response to heat; IMP:TAIR.
DR GO; GO:0009416; P:response to light stimulus; IMP:TAIR.
DR GO; GO:0006979; P:response to oxidative stress; IMP:TAIR.
DR GO; GO:0010224; P:response to UV-B; IEP:TAIR.
DR GO; GO:0009611; P:response to wounding; IMP:TAIR.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..162
FT /note="Zinc finger protein ZAT12"
FT /id="PRO_0000409721"
FT ZN_FING 39..61
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 82..104
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 72
FT /note="G -> R (in Ref. 5; AAM65582)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 162 AA; 17332 MW; 6CF61D93EE97455A CRC64;
MVAISEIKST VDVTAANCLM LLSRVGQENV DGGDQKRVFT CKTCLKQFHS FQALGGHRAS
HKKPNNDALS SGLMKKVKTS SHPCPICGVE FPMGQALGGH MRRHRNESGA AGGALVTRAL
LPEPTVTTLK KSSSGKRVAC LDLSLGMVDN LNLKLELGRT VY
