ZAT18_ARATH
ID ZAT18_ARATH Reviewed; 175 AA.
AC Q9LFG0;
DT 13-NOV-2019, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Zinc finger protein ZAT18 {ECO:0000303|PubMed:28586434};
GN Name=ZAT18 {ECO:0000303|PubMed:28586434};
GN Synonyms=JAT11 {ECO:0000303|PubMed:14973281};
GN OrderedLocusNames=At3g53600 {ECO:0000312|Araport:AT3G53600};
GN ORFNames=F4P12.300 {ECO:0000312|EMBL:CAB67667.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Bautista V.R., Kim C.J., Chen H., Wu S.Y., De Los Reyes C., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JAN-2007) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP FUNCTION, AND DOMAIN.
RX PubMed=11487705; DOI=10.2307/3871331;
RA Ohta M., Matsui K., Hiratsu K., Shinshi H., Ohme-Takagi M.;
RT "Repression domains of class II ERF transcriptional repressors share an
RT essential motif for active repression.";
RL Plant Cell 13:1959-1968(2001).
RN [6]
RP DOMAIN.
RX PubMed=14973281; DOI=10.1242/dev.00991;
RA Ohno C.K., Reddy G.V., Heisler M.G., Meyerowitz E.M.;
RT "The Arabidopsis JAGGED gene encodes a zinc finger protein that promotes
RT leaf tissue development.";
RL Development 131:1111-1122(2004).
RN [7]
RP FUNCTION, AND INDUCTION BY JASMONIC ACID AND WOUNDING.
RX PubMed=17786451; DOI=10.1007/s00299-007-0410-z;
RA Wang Z., Cao G., Wang X., Miao J., Liu X., Chen Z., Qu L.-J., Gu H.;
RT "Identification and characterization of COI1-dependent transcription factor
RT genes involved in JA-mediated response to wounding in Arabidopsis plants.";
RL Plant Cell Rep. 27:125-135(2008).
RN [8]
RP FUNCTION, DISRUPTION PHENOTYPE, INDUCTION BY ABIOTIC STRESSES, TISSUE
RP SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=28586434; DOI=10.1093/jxb/erx157;
RA Yin M., Wang Y., Zhang L., Li J., Quan W., Yang L., Wang Q., Chan Z.;
RT "The Arabidopsis Cys2/His2 zinc finger transcription factor ZAT18 is a
RT positive regulator of plant tolerance to drought stress.";
RL J. Exp. Bot. 68:2991-3005(2017).
CC -!- FUNCTION: Transcription factor involved in stress responses (Probable)
CC (PubMed:28586434). Positive regulator of the jasmonic acid
CC (JA)- mediated signaling pathway (PubMed:14973281). Triggers the up-
CC regulation of LOX3, VSP2, PAL1 and PAL2 in a JA-dependent manner
CC (PubMed:14973281). Promotes drought and osmotic stress tolerance by
CC preventing reactive oxygen species (ROS) production (e.g. H(2)O(2))
CC (PubMed:28586434). {ECO:0000269|PubMed:14973281,
CC ECO:0000269|PubMed:28586434, ECO:0000305|PubMed:11487705}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00768,
CC ECO:0000269|PubMed:28586434}.
CC -!- TISSUE SPECIFICITY: Mostly expressed in stems, siliques and leaves,
CC and, to a lower extent, in cotyledons, hypocotyls and roots.
CC {ECO:0000269|PubMed:28586434}.
CC -!- INDUCTION: Induced by jasmonic acid (MeJA) and gradually by wounding
CC (PubMed:14973281). Accumulates in response to dehydration stress
CC (PubMed:28586434). Induced by cold, osmotic, salt and drought stresses
CC in roots and shoots, and by UV-B and wounding in shoots
CC (PubMed:28586434). {ECO:0000269|PubMed:14973281,
CC ECO:0000269|PubMed:28586434}.
CC -!- DOMAIN: Contains a slightly degenerated ERF-associated amphiphilic
CC repression (EAR) motif, which may be involved in the activity of
CC transcriptional repression. {ECO:0000305|PubMed:11487705,
CC ECO:0000305|PubMed:14973281}.
CC -!- DISRUPTION PHENOTYPE: Decreased tolerance to drought stress.
CC {ECO:0000269|PubMed:28586434}.
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DR EMBL; AL132966; CAB67667.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE79115.1; -; Genomic_DNA.
DR EMBL; BT030044; ABN04782.1; -; mRNA.
DR EMBL; AB493648; BAH30486.1; -; mRNA.
DR PIR; T45900; T45900.
DR RefSeq; NP_190928.1; NM_115220.2.
DR AlphaFoldDB; Q9LFG0; -.
DR IntAct; Q9LFG0; 5.
DR STRING; 3702.AT3G53600.1; -.
DR PaxDb; Q9LFG0; -.
DR PRIDE; Q9LFG0; -.
DR DNASU; 824528; -.
DR EnsemblPlants; AT3G53600.1; AT3G53600.1; AT3G53600.
DR GeneID; 824528; -.
DR Gramene; AT3G53600.1; AT3G53600.1; AT3G53600.
DR KEGG; ath:AT3G53600; -.
DR Araport; AT3G53600; -.
DR TAIR; locus:2084046; AT3G53600.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_059471_3_0_1; -.
DR InParanoid; Q9LFG0; -.
DR OMA; HRTSMIT; -.
DR OrthoDB; 1412405at2759; -.
DR PhylomeDB; Q9LFG0; -.
DR PRO; PR:Q9LFG0; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LFG0; baseline and differential.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0042631; P:cellular response to water deprivation; IMP:TAIR.
DR GO; GO:1902584; P:positive regulation of response to water deprivation; IMP:UniProtKB.
DR GO; GO:2000022; P:regulation of jasmonic acid mediated signaling pathway; IMP:UniProtKB.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IMP:UniProtKB.
DR GO; GO:0010200; P:response to chitin; IBA:GO_Central.
DR GO; GO:0009409; P:response to cold; IEP:UniProtKB.
DR GO; GO:0009753; P:response to jasmonic acid; IEP:UniProtKB.
DR GO; GO:0006970; P:response to osmotic stress; IEP:UniProtKB.
DR GO; GO:1902074; P:response to salt; IEP:UniProtKB.
DR GO; GO:0010224; P:response to UV-B; IEP:UniProtKB.
DR GO; GO:0009414; P:response to water deprivation; IEP:UniProtKB.
DR GO; GO:0009611; P:response to wounding; IEP:UniProtKB.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..175
FT /note="Zinc finger protein ZAT18"
FT /id="PRO_0000448580"
FT ZN_FING 49..71
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 93..115
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT MOTIF 71..78
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00768"
FT MOTIF 146..152
FT /note="EAR-like (transcriptional repression)"
FT /evidence="ECO:0000305|PubMed:11487705"
SQ SEQUENCE 175 AA; 20147 MW; B58159444FAE5835 CRC64;
MKRDRSDYEE SMKHIDIVES LMMLSRSFVV KQIDVKQSTG SKTNHNNHFE CKTCNRKFDS
FQALGGHRAS HKKPKLIVDQ EQVKHRNKEN DMHKCTICDQ MFGTGQALGG HMRKHRTSMI
TEQSIVPSVV YSRPVFNRCS SSKEILDLNL TPLENDLVLI FGKNLVPQID LKFVN
