ZAT2_ARATH
ID ZAT2_ARATH Reviewed; 270 AA.
AC Q9SIJ0;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Zinc finger protein ZAT2 {ECO:0000305};
DE AltName: Full=Protein DUO1-ACTIVATED ZINC FINGER 1 {ECO:0000303|PubMed:21285328};
GN Name=ZAT2 {ECO:0000305}; Synonyms=DAZ1 {ECO:0000303|PubMed:21285328};
GN OrderedLocusNames=At2g17180 {ECO:0000312|Araport:AT2G17180};
GN ORFNames=T23A1.4 {ECO:0000312|EMBL:AAD25136.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Underwood B.A., Xiao Y.-L., Moskal W.A. Jr., Monaghan E.L., Wang W.,
RA Redman J.C., Wu H.C., Utterback T., Town C.D.;
RL Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP INDUCTION.
RX PubMed=21285328; DOI=10.1105/tpc.110.081059;
RA Borg M., Brownfield L., Khatab H., Sidorova A., Lingaya M., Twell D.;
RT "The R2R3 MYB transcription factor DUO1 activates a male germline-specific
RT regulon essential for sperm cell differentiation in Arabidopsis.";
RL Plant Cell 23:534-549(2011).
RN [6]
RP FUNCTION, INTERACTION WITH TPL, SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE,
RP AND TISSUE SPECIFICITY.
RX PubMed=24876252; DOI=10.1105/tpc.114.124743;
RA Borg M., Rutley N., Kagale S., Hamamura Y., Gherghinoiu M., Kumar S.,
RA Sari U., Esparza-Franco M.A., Sakamoto W., Rozwadowski K., Higashiyama T.,
RA Twell D.;
RT "An EAR-dependent regulatory module promotes male germ cell division and
RT sperm fertility in Arabidopsis.";
RL Plant Cell 26:2098-2113(2014).
CC -!- FUNCTION: Mediates the regulation of male germ cell division by DUO1.
CC {ECO:0000269|PubMed:24876252}.
CC -!- SUBUNIT: Interacts (via the EAR motif) with TPL.
CC {ECO:0000269|PubMed:24876252}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24876252}.
CC -!- TISSUE SPECIFICITY: Expressed exclusively in pollen.
CC {ECO:0000269|PubMed:24876252}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the germ cells following microspore
CC division, increases during development and persists into mature pollen.
CC {ECO:0000269|PubMed:24876252}.
CC -!- INDUCTION: Activated by the transcription factor DUO1.
CC {ECO:0000269|PubMed:21285328}.
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DR EMBL; AC007127; AAD25136.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC06595.1; -; Genomic_DNA.
DR EMBL; DQ056533; AAY78685.1; -; mRNA.
DR EMBL; AB493550; BAH30388.1; -; Genomic_DNA.
DR PIR; A84549; A84549.
DR RefSeq; NP_179309.1; NM_127272.2.
DR AlphaFoldDB; Q9SIJ0; -.
DR BioGRID; 1580; 5.
DR IntAct; Q9SIJ0; 4.
DR STRING; 3702.AT2G17180.1; -.
DR PaxDb; Q9SIJ0; -.
DR PRIDE; Q9SIJ0; -.
DR ProteomicsDB; 242961; -.
DR EnsemblPlants; AT2G17180.1; AT2G17180.1; AT2G17180.
DR GeneID; 816223; -.
DR Gramene; AT2G17180.1; AT2G17180.1; AT2G17180.
DR KEGG; ath:AT2G17180; -.
DR Araport; AT2G17180; -.
DR TAIR; locus:2059672; AT2G17180.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_059470_0_0_1; -.
DR InParanoid; Q9SIJ0; -.
DR OMA; RCHWEKD; -.
DR OrthoDB; 1483015at2759; -.
DR PhylomeDB; Q9SIJ0; -.
DR PRO; PR:Q9SIJ0; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9SIJ0; baseline and differential.
DR Genevisible; Q9SIJ0; AT.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0048235; P:pollen sperm cell differentiation; IEP:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; TAS:TAIR.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..270
FT /note="Zinc finger protein ZAT2"
FT /id="PRO_0000409711"
FT ZN_FING 65..87
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 148..170
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 211..233
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 100..119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 270 AA; 29556 MW; 3F35FFAE3B2DAC31 CRC64;
MSNTSNSDPN SDIPFASSNV TLPSYNQNPR RKRTKLTNNE VGSSSSSPRP KPVTQPDPDA
SQIARPCTEC GKQFGSLKAL FGHMRCHPER QWRGINPPSN FKRRINSNAA SSSSSWDPSE
EEHNIASCLL MMANGDVPTR SSEVEERFEC DGCKKVFGSH QALGGHRATH KDVKGCFANK
NITEDPPPPP PQEIVDQDKG KSVKLVSGMN HRCNICSRVF SSGQALGGHM RCHWEKDQEE
NQVRGIDLNV PAATSSDTTL GCSLDLRLGL
