ZAT6_ARATH
ID ZAT6_ARATH Reviewed; 238 AA.
AC O22533; Q8GWG1;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 01-JAN-1998, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Zinc finger protein ZAT6;
DE AltName: Full=COLD INDUCED ZINC FINGER PROTEIN 2;
GN Name=ZAT6; Synonyms=CZF2; OrderedLocusNames=At5g04340; ORFNames=T19N18.70;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=cv. Columbia;
RA Jensen R.B., Skriver K., Jespersen H.M.;
RT "C2H2 zinc finger type domains in Arabidopsis thaliana.";
RL Submitted (OCT-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=11910074; DOI=10.1126/science.1071006;
RA Seki M., Narusaka M., Kamiya A., Ishida J., Satou M., Sakurai T.,
RA Nakajima M., Enju A., Akiyama K., Oono Y., Muramatsu M., Hayashizaki Y.,
RA Kawai J., Carninci P., Itoh M., Ishii Y., Arakawa T., Shibata K.,
RA Shinagawa A., Shinozaki K.;
RT "Functional annotation of a full-length Arabidopsis cDNA collection.";
RL Science 296:141-145(2002).
RN [5]
RP INDUCTION BY COLD.
RX PubMed=15634197; DOI=10.1111/j.1365-313x.2004.02288.x;
RA Vogel J.T., Zarka D.G., Van Buskirk H.A., Fowler S.G., Thomashow M.F.;
RT "Roles of the CBF2 and ZAT12 transcription factors in configuring the low
RT temperature transcriptome of Arabidopsis.";
RL Plant J. 41:195-211(2005).
RN [6]
RP FUNCTION, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=17631527; DOI=10.1104/pp.107.101691;
RA Devaiah B.N., Nagarajan V.K., Raghothama K.G.;
RT "Phosphate homeostasis and root development in Arabidopsis are synchronized
RT by the zinc finger transcription factor ZAT6.";
RL Plant Physiol. 145:147-159(2007).
CC -!- FUNCTION: Probable transcription factor that regulates root development
CC and phosphate (Pi) acquisition and homeostasis. Probably acts as a
CC repressor of primary root growth and regulates Pi homeostasis through
CC the control of root architecture. {ECO:0000269|PubMed:17631527}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:17631527}.
CC -!- INDUCTION: By cold treatment and during Pi starvation.
CC {ECO:0000269|PubMed:15634197, ECO:0000269|PubMed:17631527}.
CC -!- MISCELLANEOUS: Seeds silencing ZAT6 fail to germinate. Plants
CC overexpressing ZAT6 have retarded growth with smaller primary roots and
CC fewer leaves.
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DR EMBL; AF022658; AAB80922.1; -; mRNA.
DR EMBL; CP002688; AED90729.1; -; Genomic_DNA.
DR EMBL; AK118868; BAC43454.1; -; mRNA.
DR RefSeq; NP_196054.1; NM_120516.4.
DR AlphaFoldDB; O22533; -.
DR BioGRID; 15592; 4.
DR IntAct; O22533; 1.
DR STRING; 3702.AT5G04340.1; -.
DR iPTMnet; O22533; -.
DR PaxDb; O22533; -.
DR PRIDE; O22533; -.
DR ProteomicsDB; 242952; -.
DR EnsemblPlants; AT5G04340.1; AT5G04340.1; AT5G04340.
DR GeneID; 830313; -.
DR Gramene; AT5G04340.1; AT5G04340.1; AT5G04340.
DR KEGG; ath:AT5G04340; -.
DR Araport; AT5G04340; -.
DR TAIR; locus:2179964; AT5G04340.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_059471_1_2_1; -.
DR InParanoid; O22533; -.
DR OMA; HGHRETF; -.
DR OrthoDB; 1395906at2759; -.
DR PhylomeDB; O22533; -.
DR PRO; PR:O22533; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; O22533; baseline and differential.
DR Genevisible; O22533; AT.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:TAIR.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0071456; P:cellular response to hypoxia; HEP:TAIR.
DR GO; GO:0055062; P:phosphate ion homeostasis; IGI:UniProtKB.
DR GO; GO:2000280; P:regulation of root development; IGI:UniProtKB.
DR InterPro; IPR044653; AZF1/2/3-like.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR45988; PTHR45988; 1.
DR SMART; SM00355; ZnF_C2H2; 2.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE 2: Evidence at transcript level;
KW Metal-binding; Nucleus; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..238
FT /note="Zinc finger protein ZAT6"
FT /id="PRO_0000409715"
FT ZN_FING 89..111
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 148..170
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 175..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 30..38
FT /note="Nuclear localization signal"
FT /evidence="ECO:0000255"
FT COMPBIAS 1..19
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 177..199
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 236
FT /note="E -> G (in Ref. 4; BAC43454)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 238 AA; 25252 MW; C3FCC19585477A34 CRC64;
MALETLTSPR LSSPMPTLFQ DSALGFHGSK GKRSKRSRSE FDRQSLTEDE YIALCLMLLA
RDGDRNRDLD LPSSSSSPPL LPPLPTPIYK CSVCDKAFSS YQALGGHKAS HRKSFSLTQS
AGGDELSTSS AITTSGISGG GGGSVKSHVC SICHKSFATG QALGGHKRCH YEGKNGGGVS
SSVSNSEDVG STSHVSSGHR GFDLNIPPIP EFSMVNGDEE VMSPMPAKKL RFDFPEKP
