ID   ZAX_XENLA               Reviewed;         224 AA.
AC   O93590;
DT   09-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   03-AUG-2022, entry version 92.
DE   RecName: Full=Homeobox protein zampogna;
DE   AltName: Full=Xzax;
GN   Name=zax {ECO:0000303|PubMed:10022957};
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1] {ECO:0000305, ECO:0000312|EMBL:AAC64197.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   TISSUE=Tadpole {ECO:0000269|PubMed:10022957};
RX   PubMed=10022957; DOI=10.1007/s004270050236;
RA   Newman C.S., Krieg P.A.;
RT   "The Xenopus bagpipe-related homeobox gene zampogna is expressed in the
RT   pharyngeal endoderm and the visceral musculature of the midgut.";
RL   Dev. Genes Evol. 209:132-134(1999).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: At early tailbud stage, expressed in the pharyngeal
CC       endoderm, concentrated within the pharyngeal clefts. Also expressed in
CC       the mesenchymal head cells in the future infrarostral cartilage.
CC       Beginning at the mid-tailbud stage, expressed in the muscular layer of
CC       the midgut. {ECO:0000269|PubMed:10022957}.
CC   -!- DEVELOPMENTAL STAGE: Expressed at a low level throughout all
CC       developmental stages. Expression levels significantly increase after
CC       the mid-tailbud stage and are maintained through the tadpole stage
CC       (stage 40). {ECO:0000269|PubMed:10022957}.
CC   -!- MISCELLANEOUS: Based on similarity to Drosophila 'bagpipe/bap', the
CC       name 'zampogna' was chosen after an Italian musical instrument related
CC       to the Scottish bagpipe. {ECO:0000269|PubMed:10022957}.
CC   -!- SIMILARITY: Belongs to the NK-3 homeobox family. {ECO:0000255}.
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DR   EMBL; AF095721; AAC64197.1; -; mRNA.
DR   RefSeq; NP_001079154.1; NM_001085685.1.
DR   AlphaFoldDB; O93590; -.
DR   SMR; O93590; -.
DR   GeneID; 373704; -.
DR   KEGG; xla:373704; -.
DR   CTD; 373704; -.
DR   Xenbase; XB-GENE-865322; nkx3-3.S.
DR   OMA; RQYCPED; -.
DR   OrthoDB; 1303626at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 373704; Expressed in testis and 2 other tissues.
DR   GO; GO:0005634; C:nucleus; NAS:UniProtKB.
DR   GO; GO:0003677; F:DNA binding; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..224
FT                   /note="Homeobox protein zampogna"
FT                   /id="PRO_0000271784"
FT   DNA_BIND        100..159
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        22..36
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        42..75
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   224 AA;  25463 MW;  18DA70F447C2294C CRC64;
     MSLTSFSIQD ILARTGGNRG KDTRTDGNNI SPPPSPSADE GHNEWPRAEN PPLTPEKEKT
     DTDSGTEDFH WERDTETANN GAFTDPSSGD RLADSPKSSK KRSRAAFSHA QVYELERRFS
     LQRYLSGPER ADLAASLKLT ETQVKIWFQN RRYKTKRKLI ATQTAPKSSL VPTRKVAVRV
     LVKDDQRQYC PEDMLSPSLL SLYHAYQYYP YMYCLPAWVP HLPL