ID   ZB182_XENLA             Reviewed;         472 AA.
AC   Q7ZWZ4;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   02-MAR-2010, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Zinc finger and BTB domain-containing protein 18.2;
DE   AltName: Full=Zinc finger protein 238.2;
GN   Name=zbtb18.2; Synonyms=znf238.2;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Transcriptional repressor that plays a role in various
CC       developmental processes. Specifically binds the consensus DNA sequence
CC       5'-[AC]ACATCTG[GT][AC]-3' which contains the E box core, and acts by
CC       recruiting chromatin remodeling multiprotein complexes (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. ZBTB18 subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH46572.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; BC046572; AAH46572.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001079635.1; NM_001086166.1.
DR   AlphaFoldDB; Q7ZWZ4; -.
DR   SMR; Q7ZWZ4; -.
DR   DNASU; 379322; -.
DR   GeneID; 379322; -.
DR   KEGG; xla:379322; -.
DR   CTD; 379322; -.
DR   Xenbase; XB-GENE-1219070; znf238.2.L.
DR   OrthoDB; 1318335at2759; -.
DR   Proteomes; UP000186698; Chromosome 8L.
DR   Bgee; 379322; Expressed in blastula and 19 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   Gene3D; 3.30.710.10; -; 1.
DR   InterPro; IPR000210; BTB/POZ_dom.
DR   InterPro; IPR011333; SKP1/BTB/POZ_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00651; BTB; 1.
DR   Pfam; PF00096; zf-C2H2; 2.
DR   SMART; SM00225; BTB; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF54695; SSF54695; 1.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS50097; BTB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Repressor;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..472
FT                   /note="Zinc finger and BTB domain-containing protein 18.2"
FT                   /id="PRO_0000391927"
FT   DOMAIN          24..91
FT                   /note="BTB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00037"
FT   ZN_FING         344..366
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         384..406
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         412..434
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         440..463
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          127..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          197..236
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          269..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..151
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        201..218
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        277..292
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   472 AA;  52691 MW;  2BD665BDDFA4C21B CRC64;
     MEFPDHSRQL LQCLSQQRHQ GFLCDCTVLV GEAQFRAHRA VLASCSMYFH LFYRDQLDKR
     DIVHLNSDIV TAPAFSLLLQ FMYEGKLEFS NLPVEDVLAA ASYLHMYDIV KVCKGKLKDK
     ELNSGEKIID DGEKDDKPVD SEEHHEHSFD ASQQKISTLD SVKPIWKEKV SGLSGLSSDL
     IGVNSVPAEA VMCKRAAGKT KANDSSPSSP LSQRSANHTH PPSDRDGALD LSFKPMPGRD
     SFHPSYVFGQ LVSDSQQQGS LPLVKHEQDL LSEQEDSQAK SPKSQQVGNP AKSLVTGLGH
     MFTGNGNSHT REDDLYQDRD ESEDEMDSSD LSTSGVLVSP GQICICPLCS KVFPSPHILQ
     LHLSSHFKDK DNSRIKMSPD GSVPTCTICG KTFSCMYTLK RHERTHSGEK PFTCGQCGKS
     FQYSHNLSRH AVVHTREKPH ACKWCERRFT QSGDLYRHIR KFHCGLVKSL VV