ZBBX_MOUSE
ID ZBBX_MOUSE Reviewed; 716 AA.
AC Q0P5X5; Q3V0J2;
DT 18-MAR-2008, integrated into UniProtKB/Swiss-Prot.
DT 19-SEP-2006, sequence version 1.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Zinc finger B-box domain-containing protein 1;
GN Name=Zbbx;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
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DR EMBL; AK133102; BAE21512.1; -; mRNA.
DR EMBL; BC050789; AAH50789.1; -; mRNA.
DR CCDS; CCDS17412.1; -.
DR RefSeq; NP_001297458.1; NM_001310529.1.
DR RefSeq; NP_766103.2; NM_172515.3.
DR AlphaFoldDB; Q0P5X5; -.
DR BioGRID; 229408; 1.
DR STRING; 10090.ENSMUSP00000103407; -.
DR iPTMnet; Q0P5X5; -.
DR PhosphoSitePlus; Q0P5X5; -.
DR PaxDb; Q0P5X5; -.
DR PRIDE; Q0P5X5; -.
DR ProteomicsDB; 298489; -.
DR Antibodypedia; 50643; 89 antibodies from 14 providers.
DR Ensembl; ENSMUST00000107778; ENSMUSP00000103407; ENSMUSG00000034151.
DR GeneID; 213234; -.
DR KEGG; mmu:213234; -.
DR UCSC; uc008pmy.1; mouse.
DR CTD; 79740; -.
DR MGI; MGI:2674085; Zbbx.
DR VEuPathDB; HostDB:ENSMUSG00000034151; -.
DR eggNOG; ENOG502QZ7B; Eukaryota.
DR GeneTree; ENSGT00390000018298; -.
DR InParanoid; Q0P5X5; -.
DR OMA; KMDWKSQ; -.
DR OrthoDB; 242112at2759; -.
DR PhylomeDB; Q0P5X5; -.
DR TreeFam; TF337517; -.
DR BioGRID-ORCS; 213234; 5 hits in 72 CRISPR screens.
DR PRO; PR:Q0P5X5; -.
DR Proteomes; UP000000589; Chromosome 3.
DR RNAct; Q0P5X5; protein.
DR Bgee; ENSMUSG00000034151; Expressed in spermatid and 20 other tissues.
DR ExpressionAtlas; Q0P5X5; baseline and differential.
DR Genevisible; Q0P5X5; MM.
DR GO; GO:0031514; C:motile cilium; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0003341; P:cilium movement; IBA:GO_Central.
DR InterPro; IPR037688; ZBBX.
DR InterPro; IPR000315; Znf_B-box.
DR PANTHER; PTHR28634; PTHR28634; 1.
DR PROSITE; PS50119; ZF_BBOX; 1.
PE 1: Evidence at protein level;
KW Metal-binding; Reference proteome; Zinc; Zinc-finger.
FT CHAIN 1..716
FT /note="Zinc finger B-box domain-containing protein 1"
FT /id="PRO_0000325814"
FT ZN_FING 12..58
FT /note="B box-type; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT REGION 78..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 381..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 420..447
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 657..698
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 86..112
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 17
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 20
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 40
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT BINDING 45
FT /ligand="Zn(2+)"
FT /ligand_id="ChEBI:CHEBI:29105"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00024"
FT CONFLICT 677
FT /note="S -> F (in Ref. 1; BAE21512)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 716 AA; 80339 MW; C8107F99BF108F66 CRC64;
MAHSTGSENP KTKRKVCGQC ENKAALLVCL ECGEDYCSGC FAKMHQKGAL KFHRTTLLQP
KSQILSNILI AAHQFIKEEN PPNEGNHPAE ASSKSQQKPK ALLQNSSEVG ATASEGGEGE
NPRCKVMWEM PFDEEASAQS FREALTQWRA GHQEENKEEE VHAKKPVFIF LDSVEECEVQ
TNLKMWTEPI NIEFTEDSLS YMETLWLKKY RRTPQEQLRT MLPNTFTHPH QATAEAQCTQ
NENESDSDVE EIKIKSPPLF MPVEKLNIER PPPSLTIVEL DDTHGAEFED PGIAVPYRVE
LADSESQLSS TFTDYQTCFP CENEIHHHLI FNKGKADLLS LCLRTNSRYH KDDIKDFGNT
VESCTYSDEF KKIGETTSFE KNETEKNIDP QNNKDSVDSC MSLGSKGSLP TIDSSTSFIE
ENSSQDTNTS LKCSNQNERS NLGNSKTAKE PLFQKVTIRK KLIKERYQGP KKFYSVDKNE
RLDVFPSSSI KGSHSCSEIT STVSEDKMWI PLSSLSGYAG SADALCDQQS DENPLPNMQQ
QKSGQKSQRP STANIPISNP DQKDTSCLLF SYTRSKSAAA QMPSRAASEI SEIEYIDVTD
QSELFGGNTA DRQALDTLEK ELNILRKPAD PSEDPHSLPS EELQAFNDNF LTLSQMSKDL
LEMSRESDPH GAESSSSGRN PEIQPLLSLG DYSTDEEEDE FLDKQHVIKL PWEKRA
