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ZBED4_MOUSE
ID   ZBED4_MOUSE             Reviewed;        1168 AA.
AC   Q80WQ9; Q3UPJ9; Q80TV3; Q8R329;
DT   02-MAR-2010, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 118.
DE   RecName: Full=Zinc finger BED domain-containing protein 4;
GN   Name=Zbed4; Synonyms=Kiaa0637;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA   Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA   Nakajima D., Nagase T., Ohara O., Koga H.;
RT   "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT   The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT   identified by screening of terminal sequences of cDNA clones randomly
RT   sampled from size-fractionated libraries.";
RL   DNA Res. 10:35-48(2003).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=Czech II; TISSUE=Limb, and Mammary tumor;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RX   PubMed=19369242; DOI=10.1167/iovs.08-2751;
RA   Saghizadeh M., Akhmedov N.B., Yamashita C.K., Gribanova Y., Theendakara V.,
RA   Mendoza E., Nelson S.F., Ljubimov A.V., Farber D.B.;
RT   "ZBED4, a BED-type zinc-finger protein in the cones of the human retina.";
RL   Invest. Ophthalmol. Vis. Sci. 50:3580-3588(2009).
RN   [5]
RP   FUNCTION, AND TISSUE SPECIFICITY.
RX   PubMed=22693546; DOI=10.1371/journal.pone.0035317;
RA   Mokhonov V.V., Theendakara V.P., Gribanova Y.E., Ahmedli N.B., Farber D.B.;
RT   "Sequence-specific binding of recombinant Zbed4 to DNA: insights into Zbed4
RT   participation in gene transcription and its association with other
RT   proteins.";
RL   PLoS ONE 7:e35317-e35317(2012).
CC   -!- FUNCTION: Transcriptional regulator that binds to poly-guanine tracts
CC       in gene promoters and activates transcription (By similarity). Able to
CC       bind single- and double-stranded DNA and RNA (PubMed:22693546).
CC       {ECO:0000250|UniProtKB:O75132, ECO:0000269|PubMed:22693546}.
CC   -!- SUBUNIT: Homodimer; via C-terminus (By similarity). Interacts with MYH9
CC       (By similarity). Interacts with SAFB/SAFB1 (By similarity).
CC       {ECO:0000250|UniProtKB:O75132}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:O75132}. Nucleus
CC       {ECO:0000269|PubMed:19369242}. Photoreceptor inner segment
CC       {ECO:0000250|UniProtKB:O75132}.
CC   -!- TISSUE SPECIFICITY: Expressed in the thymus (PubMed:19369242). In the
CC       retina, expressed in the cone photoreceptors (PubMed:19369242,
CC       PubMed:22693546). {ECO:0000269|PubMed:19369242,
CC       ECO:0000269|PubMed:22693546}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAC65617.1; Type=Miscellaneous discrepancy; Note=The sequence differs from that shown because it seems to be derived from a pre-mRNA.; Evidence={ECO:0000305};
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DR   EMBL; AK122335; BAC65617.1; ALT_SEQ; Transcribed_RNA.
DR   EMBL; AK143488; BAE25396.1; -; mRNA.
DR   EMBL; BC026763; AAH26763.1; -; mRNA.
DR   EMBL; BC052174; AAH52174.1; -; mRNA.
DR   CCDS; CCDS27731.1; -.
DR   RefSeq; NP_852077.1; NM_181412.3.
DR   RefSeq; XP_006520903.1; XM_006520840.3.
DR   RefSeq; XP_006520904.1; XM_006520841.3.
DR   AlphaFoldDB; Q80WQ9; -.
DR   SMR; Q80WQ9; -.
DR   STRING; 10090.ENSMUSP00000035437; -.
DR   iPTMnet; Q80WQ9; -.
DR   PhosphoSitePlus; Q80WQ9; -.
DR   EPD; Q80WQ9; -.
DR   jPOST; Q80WQ9; -.
DR   PaxDb; Q80WQ9; -.
DR   PeptideAtlas; Q80WQ9; -.
DR   PRIDE; Q80WQ9; -.
DR   ProteomicsDB; 275336; -.
DR   Antibodypedia; 59180; 12 antibodies from 7 providers.
DR   Ensembl; ENSMUST00000041297; ENSMUSP00000035437; ENSMUSG00000034333.
DR   GeneID; 223773; -.
DR   KEGG; mmu:223773; -.
DR   UCSC; uc007xem.1; mouse.
DR   CTD; 9889; -.
DR   MGI; MGI:2682302; Zbed4.
DR   VEuPathDB; HostDB:ENSMUSG00000034333; -.
DR   eggNOG; KOG1121; Eukaryota.
DR   GeneTree; ENSGT00940000161365; -.
DR   HOGENOM; CLU_006260_0_0_1; -.
DR   InParanoid; Q80WQ9; -.
DR   OMA; HMWRAHK; -.
DR   OrthoDB; 223749at2759; -.
DR   PhylomeDB; Q80WQ9; -.
DR   TreeFam; TF322818; -.
DR   BioGRID-ORCS; 223773; 7 hits in 72 CRISPR screens.
DR   ChiTaRS; Zbed4; mouse.
DR   PRO; PR:Q80WQ9; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; Q80WQ9; protein.
DR   Bgee; ENSMUSG00000034333; Expressed in dorsal pancreas and 246 other tissues.
DR   Genevisible; Q80WQ9; MM.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR   GO; GO:0001917; C:photoreceptor inner segment; IEA:UniProtKB-SubCell.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:ARUK-UCL.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR   GO; GO:0003723; F:RNA binding; IDA:UniProtKB.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IDA:ARUK-UCL.
DR   GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:UniProtKB.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:UniProtKB.
DR   InterPro; IPR008906; HATC_C_dom.
DR   InterPro; IPR012337; RNaseH-like_sf.
DR   InterPro; IPR003656; Znf_BED.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   Pfam; PF05699; Dimer_Tnp_hAT; 1.
DR   Pfam; PF02892; zf-BED; 4.
DR   SUPFAM; SSF53098; SSF53098; 1.
DR   SUPFAM; SSF57667; SSF57667; 4.
DR   PROSITE; PS50808; ZF_BED; 4.
PE   2: Evidence at transcript level;
KW   Activator; Cytoplasm; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW   Phosphoprotein; Reference proteome; Repeat; RNA-binding; Transcription;
KW   Transcription regulation; Ubl conjugation; Zinc; Zinc-finger.
FT   CHAIN           1..1168
FT                   /note="Zinc finger BED domain-containing protein 4"
FT                   /id="PRO_0000391794"
FT   ZN_FING         114..171
FT                   /note="BED-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   ZN_FING         284..341
FT                   /note="BED-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   ZN_FING         456..512
FT                   /note="BED-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   ZN_FING         557..614
FT                   /note="BED-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   REGION          22..55
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          362..443
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1040..1059
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1083..1168
FT                   /note="Required for homodimerization and nuclear
FT                   accumulation"
FT                   /evidence="ECO:0000250|UniProtKB:O75132"
FT   COMPBIAS        372..443
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         135
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         138
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         159
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         164
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         305
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         308
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         329
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         334
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         477
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         480
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         500
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         505
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         578
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         581
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         602
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   BINDING         607
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_label="4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00027"
FT   MOD_RES         623
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:O75132"
FT   CROSSLNK        42
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:O75132"
FT   CROSSLNK        489
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:O75132"
FT   CONFLICT        743
FT                   /note="L -> P (in Ref. 1; BAC65617)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   1168 AA;  130402 MW;  57A65CC20B6FE0BC CRC64;
     MEDKQETCPK GDSDFVSDKV NFKTEEDDDQ TPCHSLEQVD FKSESEDMRQ TDSGDEQADI
     RAASCACQPS GKFLAAESED DYGSLFSQYS STLYSVAMEA VTQSLLSSRH ISSRKKSPAW
     KHFFISPRDS TKAICTYCMK EFSRGKNEKD LSTSCLMRHV RRAHPTKLIQ ENGSLSAGSS
     FSPPSLLLPP QPADVGDLST VLSPVRLVQK MAPKIPSPDQ IMEESVTVVS SEELSSDVSV
     TEKYSREEAL AGSSPNLSML HYDDASETMA DRNLSLPKST SGSRRRSAVW KHFYLSPLDS
     SKAVCVHCMN EFSRGKNGKD LGTSCLIRHM WRAHRSIVLQ ENGGNTGIPP LYPMPPTLLP
     ALLPPEGDLN SASLSPGKQV KESPSASSSP ERLPEDLSSH TNPGDVSRED VSMLSSSDDL
     GEASVVSSPE KQPADTVNPR FESGTVFQQN KKVMRRLKSE VWHHFSLAPM DSLKAVCRYC
     SCVISRGKKG DVGTSCLMRH LYRRHPEVVG NQKDFLGASL ANSPYATLAS AESSSKLTDL
     PAVVRKNHQG VFPTNSKKTS KLWNHFSICS ADSTKVVCLH CGRTISRGKK PTNLGTSCLL
     RHLQRFHGHV LKNDVSEATL SRSPGIRRPL GIELSGPSSF RDSTEKFYDS HPVAKKITSL
     IAEMIALDLQ PYSLVDNVGF NRLLEYLKPQ YSLPSPSYFS RTAIPGMYDN VKQIIMSHLK
     EAESGVVHFT SGIWMSSQTR EYLTLTAHWV TFASAVRPHC EDHHCSALLD VSQIDCDYSG
     NSIQKQLECW WEAWVTSIGL QIGITVTDNP SIGKMLSEGE HSSVQCFSHT VNLIVSEAIK
     SQRMVQNLLS IARKLCERVH RSPRAREKLA ELQKEYELPQ HQLIQDVPSK WSTSFHMLER
     LIEQKRAVNE VSIECNFREL ISCDQWEVMQ SVCHVLRPFD AASREMSAHM STLSQVIPMI
     HILSRKVEML FGETMGIDTM LKSLKEAMAS RLSATLHDPR YIFATLLDPR YKASLFTEEE
     AEQYRQDLIR ELEILNSTSE DTATSNGCDS GSPLKDTGTE ESLWSLAPIK RDQREKLPED
     MVLAYLEEEV LEHSCDPLTY WNLKRSSWPG LSTLAVRFLG CPPSTVPSEK LFSTPMDAGS
     FGQPRLMMEH FEKLIFLKVN LPLICFQY
 
 
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